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ABCG2 (NM_004827) Human Untagged Clone
CAT＃: SC117127
ABCG2 (untagged)-Human ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2)
CNY 7,328.00
| Cited in 5 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1; UAQTL1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_004827 edited
TGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGG ACCGAGCTCTATTAAGCTGAAAAGATAAAAACTCTCCAGATGTCTTCCAGTAATGTCGAA GTTTTTATCCCAGTGTCACAAGGAAACACCAATGGCTTCCCCGCGACAGCTTCCAATGAC CTGAAGGCATTTACTGAAGGAGCTGTGTTAAGTTTTCATAACATCTGCTATCGAGTAAAA CTGAAGAGTGGCTTTCTACCTTGTCGAAAACCAGTTGAGAAAGAAATATTATCGAATATC AATGGGATCATGAAACCTGGTCTCAACGCCATCCTGGGACCCACAGGTGGAGGCAAATCT TCGTTATTAGATGTCTTAGCTGCAAGGAAAGATCCAAGTGGATTATCTGGAGATGTTCTG ATAAATGGAGCACCGCGACCTGCCAATTTCAAATGTAATTCAGGTTACGTGGTACAAGAT GATGTTGTGATGGGCACTCTGACGGTGAGAGAAAACTTACAGTTCTCAGCAGCTCTTCGG CTTGCAACAACTATGACGAATCATGAAAAAAACGAACGGATTAACAGGGTCATTCAAGAG TTAGGTCTGGATAAAGTGGCAGACTCCAAGGTTGGAACTCAGTTTATCCGTGGTGTGTCT GGAGGAGAAAGAAAAAGGACTAGTATAGGAATGGAGCTTATCACTGATCCTTCCATCTTG TTCTTGGATGAGCCTACAACTGGCTTAGACTCAAGCACAGCAAATGCTGTCCTTTTGCTC CTGAAAAGGATGTCTAAGCAGGGACGAACAATCATCTTCTCCATTCATCAGCCTCGATAT TCCATCTTCAAGTTGTTTGATAGCCTCACCTTATTGGCCTCAGGAAGACTTATGTTCCAC GGGCCTGCTCAGGAGGCCTTGGGATACTTTGAATCAGCTGGTTATCACTGTGAGGCCTAT AATAACCCTGCAGACTTCTTCTTGGACATCATTAATGGAGATTCCACTGCTGTGGCATTA AACAGAGAAGAAGACTTTAAAGCCACAGAGATCATAGAGCCTTCCAAGCAGGATAAGCCA CTCATAGAAAAATTAGCGGAGATTTATGTCAACTCCTCCTTCTACAAAGAGACAAAAGCT GAATTACATCAACTTTCCGGGGGTGAGAAGAAGAAGAAGATCACAGTCTTCAAGGAGATC AGCTACACCACCTCCTTCTGTCATCAACTCAGATGGGTTTCCAAGCGTTCATTCAAAAAC TTGCTGGGTAATCCCCAGGCCTCTATAGCTCAGATCATTGTCACAGTCGTACTGGGACTG GTTATAGGTGCCATTTACTTTGGGCTAAAAAATGATTCTACTGGAATCCAGAACAGAGCT GGGGTTCTCTTCTTCCTGACGACCAACCAGTGTTTCAGCAGTGTTTCAGCCGTGGAACTC TTTGTGGTAGAGAAGAAGCTCTTCATACATGAATACATCAGCGGATACTACAGAGTGTCA TCTTATTTCCTTGGAAAACTGTTATCTGATTTATTACCCATGAGGATGTTACCAAGTATT ATATTTACCTGTATAGTGTACTTCATGTTAGGATTGAAGCCAAAGGCAGATGCCTTCTTC GTTATGATGTTTACCCTTATGATGGTGGCTTATTCAGCCAGTTCCATGGCACTGGCCATA GCAGCAGGTCAGAGTGTGGTTTCTGTAGCAACACTTCTCATGACCATCTGTTTTGTGTTT ATGATGATTTTTTCAGGTCTGTTGGTCAATCTCACAACCATTGCATCTTGGCTGTCATGG CTTCAGTACTTCAGCATTCCACGATATGGATTTACGGCTTTGCAGCATAATGAATTTTTG GGACAAAACTTCTGCCCAGGACTCAATGCAACAGGAAACAATCCTTGTAACTATGCAACA TGTACTGGCGAAGAATATTTGGTAAAGCAGGGCATCGATCTCTCACCCTGGGGCTTGTGG AAGAATCACGTGGCCTTGGCTTGTATGATTGTTATTTTCCTCACAATTGCCTACCTGAAA TTGTTATTTCTTAAAAAATATTCTTAAATTTCCCCTTAATTCAGTATGATTTATCCTCAC ATAAAAAAGAAGCACTTTGATTGAAGTATTCAATCAAGTTTTTTTGTTGTTTTCTGTTCC CTTGCCA >OriGene 5' read for NM_004827 unedited
NGGCCGCTCAGGATTTTCGTAAACGACTTACTATAGGCGGCCGCGAATTCGCACGAGAAC CGAGCTCTATTAAGCTGAAAAAATAAAAACTCTCCAGATGTCTTCCAGTAATGTCGAAGT TTTTATCCCAGTGTCACAAGGAAACACCAATGGCTTCCCCGCGACAGCTTCCAATGACCT GAAGGCATTTACTGAAGGAGCTGTGTTAAGTTTTCATAACATCTGCTATCGAGTAAAACT GAAGAGTGGCTTTCTACCTTGTCGAAAACCAGTTGAGAAAGAAATATTATCGAATATCAA TGGGATCATGAAACCTGGTCTCAACGCCATCCTGGGACCCACAGGTGGAGGCAAATCTTC GTTATTAGATGTCTTAGCTGCAAGGAAAGATCCAAGTGGATTATCTGGAGATGTTCTGAT AAATGGAGCACCGCGACCTGCCAATTTCAAATGTAATTCAGGTTACGTGGTACAAGATGA TGTTGTGATGGGCACTCTGACGGTGAGAGAAAACTTACAGTTCTCAGCAGCTCTTCGGCT TGCAACAACTATGACGAATCATGAAAAAAACGAACGGATTAACAGGGTCATTCAAGAGTT AGGTCTGGATAAAGTGGCAGACTCCAAGGTTGGAACTCAGTTTATCCGTGGTGTGTCTGG AGGAGAAAGAAAAAGGACTAGTATAGGAATGGAGCTTATCACTGATCCTTCCATCTTGTT CTTGGATGAGCCTACAACTGGCTTAGACTCAAGCACAGCANATGCTGTCCTTTTGCTCCT GAAAGGATGTCTAAGCAGGNACGAACAATCATCTTCTCCATTCATCAGCCTCGATATTCC ATCTTCAAGTTGTTGATAGCCTCACCTTATTNGCCTCANGAAGACTTATGNTNCACGGNC CCTGCTCAGNAGCCTTNGGGATCTTTGAAATCAGCTGTTATCACTGTGGAGGCCTATAT >OriGene 3' read for NM_004827 unedited
ACTTGGACGCGGCCGCATCTATGATCAGTTTTTTTTTTTTTTTTTTTAAGTTCTATTAAC TTTAATGTGCTTATCAAAAAGATTTTTTTCTATCACGGAGGCTTTTTTTACCCTATAAGA CAGAATCTTTTTTCCAACATATTTTCAATTTTACATTTCCAGTATAGCATTAATACATTT GTCATTTATTAAATAATGGCAAACCATAGCATCATAAAGTATTAAGACTGAAGGGCTACT AACCTACCTATTCATTTTAAAGATGAGGAAACAAATGCCAGAGACAGTAATAACTTGTCA GGAGTTTCCAGAATTCAATTCTCCTTTTTTAGATTAATAAATTAGACCAGATTTCTTCCC CATGGTTACTGTCTGAGGAGATTAACTAATATGCGATACATGATGTCTTGGGTTCTTTCA TGTTTAATTCAGTTTGTTGAGATTTCTAAAAATGTATCTCTTTAAAACAATTGCTGCTGT GCAACAGTGTGATGGCAAGGGAACAGAAAACAACAAAAAAACTTGATTGAATACTTCAAT CAAAGTGCTTCTTTTTTATGTGAGGATAAATCATACTGAATTAAGGGGAAATTTAAGAAT ATTTTTTAAGAAATAACAATTTCAGGTAGGCAATTGTGAGGAAAATAACAATCATACAAG CCAAGGCCACGTGATTCTTCCACAAGCCCCAGGGTGAGAGATCGATGCCCTGCTTTACCA AATATTCTTCGCCAGTACATGTTGCATAGTTACAAAGATTGTTTCCTGTTGCATTGAGTC CTGAGCAGAAGTTTTGTCCCAAAATCCATTATGCTGCAAAGCCGTAAATCCATATCGNGG AATGCTCGAGTACTGGAGCCATGACAGNCCAGAATGCATGGGTTGTGAGATTGCACANCA GACCTGAAAAAATCTCATAAACACAAACAGATGTCCTGANAAATGTGCTACGAAACCCAC TCTGTACTGCTGCTATGGCANTGCCATG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004827 |
| Insert Size | 2700 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004827.2, NP_004818.2 |
| RefSeq Size | 4445 bp |
| RefSeq ORF | 1968 bp |
| Locus ID | 9429 |
| UniProt ID | Q9UNQ0 |
| Domains | ABC_tran, AAA |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | ABC transporters |
| Gene Summary | The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] Transcript Variant: This variant (1) encodes the longest isoform (1). |
Citations (5)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
In vitro and in vivo identification of ABCB1 as an efflux transporter of bosutinib
,Redaelli, S;Perini, P;Ceccon, M;Piazza, R;Rigolio, R;Mauri, M;Boschelli, F;Giannoudis, A;Gambacorti-Passerini, C;,
J Hematol Oncol
,PubMed ID 26149173
[ABCG2]
|
|
Endocytosis of ABCG2 drug transporter caused by binding of 5D3 antibody: trafficking mechanisms and intracellular fate
,Studzian, M;Bartosz, G;Pulaski, L;,
Biochim. Biophys. Acta
,PubMed ID 25918011
[ABCG2]
|
|
Influence of HIV antiretrovirals on methadone N-demethylation and transport
,Campbell, SD;Gadel, S;Friedel, C;Crafford, A;Regina, KJ;Kharasch, ED;,
Biochem. Pharmacol.
,PubMed ID 25801005
[ABCG2]
|
|
Involvement of Extracellular Vesicle long non-coding RNA (linc-VLDLR) in Tumor Cell Responses to Chemotherapy
,Takahashi, K;Yan, IK;Wood, J;Haga, H;Patel, T;,
Mol. Cancer Res.
,PubMed ID 24874432
[ABCG2]
|
|
Impact of genetic variability in the ABCG2 gene on ABCG2 expression, function, and interaction with AT1 receptor antagonist telmisartan
,Deppe, S;Ripperger, A;Weiss, J;Ergün, S;Benndorf, RA;,
Biochem. Biophys. Res. Commun., Jan 2014.
,PubMed ID 24388985
[ABCG2]
|
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC205640 | ABCG2 (Myc-DDK-tagged)-Human ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2) |
CNY 7,312.00 |
|
| RC205640L1 | Lenti ORF clone of Human ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2), Myc-DDK-tagged |
CNY 9,712.00 |
|
| RC205640L2 | Lenti ORF clone of Human ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2), mGFP tagged |
CNY 9,712.00 |
|
| RC205640L3 | Lenti ORF clone of Human ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2), Myc-DDK-tagged |
CNY 9,712.00 |
|
| RC205640L4 | Lenti ORF clone of Human ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2), mGFP tagged |
CNY 9,712.00 |
|
| RG205640 | ABCG2 (tGFP-tagged) - Human ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2) |
CNY 8,912.00 |
|
| SC320948 | ABCG2 (untagged)-Human ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2) |
CNY 7,328.00 |
