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p27 KIP 1 (CDKN1B) (NM_004064) Human Untagged Clone
CAT＃: SC117607
CDKN1B (untagged)-Human cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B)
CNY 2,950.00
| Cited in 5 publications. |
Product images
热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CDKN4; KIP1; MEN1B; MEN4; P27KIP1 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_004064 edited
GAATTCGCCATATTGGGCCACTAAAAAAAGGGGGCTCGTCTTTTCGGGGTGTTTTTCTCCCCCTCCCCTG TCCCCGCTTGCTCACGGCTCTGCGACTCCGACGCCGGCAAGGTTTGGAGAGCGGCTGGGTTCGCGGGACC CGCGGGCTTGCACCCGCCCAGACTCGGACGGGCTTTGCCACCCTCTCCGCTTGCCTGGTCCCCTCTCCTC TCCGCCCTCCCGCTCGCCAGTCCATTTGATCAGCGGAGACTCGGCGGCCGGGCCGGGGCTTCCCCGCAGC CCCTGCGCGCTCCTAGAGCTCGGGCCGTGGCTCGTCGGGGTCTGTGTCTTTTGGCTCCGAGGGCAGTCGC TGGGCTTCCGAGAGGGGTTCGGGCTGCGTAGGGGCGCTTTGTTTTGTTCGGTTTTGTTTTTTTGAGAGTG CGAGAGAGGCGGTCGTGCAGACCCGGGAGAAAGATGTCAAACGTGCGAGTGTCTAACGGGAGCCCTAGCC TGGAGCGGATGGACGCCAGGCAGGCGGAGCACCCCAAGCCCTCGGCCTGCAGGAACCTCTTCGGCCCGGT GGACCACGAAGAGTTAACCCGGGACTTGGAGAAGCACTGCAGAGACATGGAAGAGGCGAGCCAGCGCAAG TGGAATTTCGATTTTCAGAATCACAAACCCCTAGAGGGCAAGTACGAGTGGCAAGAGGTGGAGAAGGGCA GCTTGCCCGAGTTCTACTACAGACCCCCGCGGCCCCCCAAAGGTGCCTGCAAGGTGCCGGCGCAGGAGAG CCAGGATGTCAGCGGGAGCCGCCCGGCGGCGCCTTTAATTGGGGCTCCGGCTAACTCTGAGGACACGCAT TTGGTGGACCCAAAGACTGATCCGTCGGACAGCCAGACGGGGTTAGCGGAGCAATGCGCAGGAATAAGGA AGCGACCTGCAACCGACGATTCTTCTACTCAAAACAAAAGAGCCAACAGAACAGAAGAAAATGTTTCAGA CGGTTCCCCAAATGCCGGTTCTGTGGAGCAGACGCCCAAGAAGCCTGGCCTCAGAAGACGTCAAACGTAA ACAGCTCGAATTAAGAATATGTTTCCTTGTTTATCAGATACATCACTGCTTGATGAAGCAAGGAAGATAT ACATGAAAATTTTAAAAATACATATCGCTGACTTCATGGAATGGACATCCTGTATAAGCACTGAAAAACA ACAACACAATAACACTAAAATTTTAGGCACTCTTAAATGATCTGCCTCTAAAAGCGTTGGATGTAGCATT ATGCAATTAGGTTTTTCCTTATTTGCTTCATTGTACTACCTGTGTATATAGTTTTTACCTTTTATGTAGC ACATAAACTTTGGGGAAGGGAGGGCAGGGTGGGGCTGAGGAACTGACGTGGAGCGGGGTATGAAGAGCTT GCTTTGATTTACAGCAAGTAGATAAATATTTGACTTGCATGAAGAGAAGCAATTTTGGGGAAGGGTTTGA ATTGTTTTCTTTAAAGATGTAATGTCCCTTTCAGAGACAGCTGATACTTCATTTAAAAAAATCACAAAAA TTTGAACACTGGCTAAAGATAATTGCTATTTATTTTTACAAGAAGTTTATTCTCATTTGGGAGATCTGGT GATCTCCCAAGCTATCTAAAGTTTGTTAGATAGCTGCATGTGGCTTTTTTAAAAAAGCAACAGAAACCTA TCCTCACTGCCCTCCCCAGTCTCTCTTAAAGTTGGAATTTACCAGTTAATTACTCAGCAGAATGGTGATC ACTCCAGGTAGTTTGGGGCAAAAATCCGAGGTGCTTGGGAGTTTTGAATGTTAAGAATTGACCATCTGCT TTTATTAAATTTGTTGACAAAATTTTCTCATTTTCTTTTCACTTCGGGCTGTGTAAACACAGTCAAAATA ATTCTAAATCCCTCGATATTTTTAAAGATCTGTAAGTAACTTCACATTAAAAAATGAAATATTTTTTAAT TTAAAGCTTACTCTGTCCATTTATCCACAGGAAAGTGTTATTTTTAAAGGAAGGTTCATGTAGAGAAAAG CACACTTGTAGGATAAGTGAAATGGATACTACATCTTTAAACAGTATTTCATTGCCTGTGTATGGAAAAA CCATTTGAAGTGTACCTGTGTACATAACTCTGTAAAAACACTGAAAAATTATACTAACTTATTTATGTTA AAAGATTTTTTTTAATCTAGACAATATACAAGCCAAAGTGGCATGTTTTGTGCATTTGTAAATGCTGTGT TGGGTAGAATAGGTTTTCCCCTCTTTTGTTAAATAATATGGCTATGCTTAAAAGGTTGCATACTGAGCCA AGTATAATTTTTTGTAATGTGTGAAAAAGATGCCAATTATTGTTACACATTAAGTAATCAATAAAGAAAA CTTCCATAGCTAAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_004064 unedited
TCTTTCCCCGCCCGTTGCCGCATTGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAG CAGAGCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGCG AATTCGGCACGAGGGGCCACTAAAAAAAGGGGGCTCGTCTTTTCGGGGTGTTTTTCTCCC CCTCCCCTGTCCCCGCTTGCTCACGGCTCTGCGACTCCGACGCCGGCAAGGTTTGGAGAG CGGCTGGGTTCGCGGGACCCGCGGGCTTGCACCCGCCCAGACTCGGACGGGCTTTGCCAC CCTCTCCGCTTGCCTGGTCCCCTCTCCTCTCCGCCCTCCCGCTCGCCAGTCCATTTGATC AGCGGAGACTCGGCGGCCGGGCCGGGGCTTCCCCGCAGCCCCTGCGCGCTCCTAGAGCTC GGGCCGTGGCTCGTCGGGGTCTGTGTCTTTTGGCTCCGAGGGCAGTCGCTGGGCTTCCGA GAGGGGTTCGGGCTGCGTAGGGGCGCTTTGTTTTGTTCGGTTTTGTTTTTTTGAGAGTGC GAGAGAGGCGGTCGTGCAGACCCGGGAGAAAGATGTCAAACGTGCGAGTGTCTAACGGGA GCCCTAGCCTGGAGCGGATGGACGCCAGGCAGGCGGAGCACCCCAAGCCCTCGGCCTGCA GGAACCTCTTCGGCCCGGTGGACCACGAAGAGTTAACCCGGGACTTGGAGAAGCACTGCA GAGACATGGAAGAGGCGAGCCAGCGCAAGTGGAATTTCGATTTTCAGAATCACAAACCCC TAGAGGGCAAGTACGAGTGGCAAGAGGTGGAGAAGGGCANCTTGCCCGATTCTACTACAG ACCCCCGCGGCCCCCCAAAGTGCCTGCCAGGTGCCCCGCGCAGANAGCANGATGTCAGCG GGAGCCGCCCCGNCGGCGCCTTTATTC >OriGene 3' read for NM_004064 unedited
GGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTAGCTATGGAAGTTTTCTTTAT TGATTACTTAATGTGTAACAATAATTGGCATCTTTTTCACACATTACAAAAAATTATACT TGGCTCAGTATGCAACCTTTTAAGCATAGCCATATTATTTAACAAAAGAGGGGAAAACCT ATTCTACCCAACACAGCATTTACAAATGCACAAAACATGCCACTTTGGCTTGTATATTGT CTAGATTAAAAAAAATCTTTTAACATAAATAAGTTAGTATAATTTTTCAGTGTTTTTACA GAGTTATGTACACAGGTACACTTCAAATGGTTTTTCCATACACAGGCAATGAAATACTGT TTAAAGATGTAGTATCCATTTCACTTATCCTACAAGTGTGCTTTTCTCTACATGAACCTT CCTTTAAAAATAACACTTTCCTGTGGATAAATGGACAGAGTAAGCTTTAAATTAAAAAAT ATTTCATTNTTTAATGTGAAGTTACTTACAGATCTTTAAAAATATCGAGGGATTTAGAAT TATTTTGACTGTGTTTACACAGCCCGAAGTGAAAAGAAAATGAGAAAATTTTGTCAACAA ATTTAATAAAAGCAGATGGTCAATTCTTAACATTCAAACTCCCAAGCACCTCGGATTTTT GCCCCAACTACCTGGAGTGATCACCATTCTGCTGAGTAANTAACTGGTAAAATCCAACTT TAGAGAGACTGGNGAGGGCAGTGAGGATAGTTTTCTGNTGCTTTTTTAAAAAGCCACATG CAGCTATCTACCAAACTTTAGATAGCTTGGGAGATCACCAAATCTTCCAAATGAGAATAA AACTCCTGGAAAAATAAATAGCAATTATCTTTAGCCACGGGTCCAAATTTTGGGGATTTT TTTAAATGAAAGATCAGCTGTCTCTGGAAGGGGACTTACATTCTTTAAGAAACCATTCAA ACCCTTTCCCAAAATGCTTCCCTTCTGCAAGACAAATTTATTTATTGCTGGAAATAAAGC AGCCTTATACCCGCTCCGAGGAGTTCTTCAGCCCCCCTGCCTCCTTCCAAAGT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004064 |
| Insert Size | 597 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_004064.2, NP_004055.1 |
| RefSeq Size | 2422 bp |
| RefSeq ORF | 597 bp |
| Locus ID | 1027 |
| UniProt ID | P46527 |
| Domains | CDI |
| Protein Families | Druggable Genome |
| Protein Pathways | Cell cycle, Chronic myeloid leukemia, ErbB signaling pathway, Pathways in cancer, Prostate cancer, Small cell lung cancer |
| Gene Summary | This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014] |
Citations (5)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Mediator Kinase Inhibition Further Activates Super-Enhancer Associated Genes in AML
,null,
Nature
,PubMed ID 26416749
[CDKN1B]
|
|
Inhibition of mTOR Kinase by AZD8055 Can Antagonize Chemotherapy-induced Cell Death through Autophagy Induction and Down-regulation of p62/Sequestosome 1
,Shengbing Huang, Zhineng J. Yang, Chunrong Yu, and Frank A. Sinicrope,
J. Biol. Chem., Nov 2011; 286: 40002 - 40012.
[CDKN1B]
|
|
Mechanism of p27 Upregulation Induced by Downregulation of Cathepsin B and uPAR in Glioma
,null,
Molecular Oncology
,PubMed ID 21840777
[CDKN1B]
|
|
Discovery of a distinct domain in cyclin A sufficient for centrosomal localization independently of Cdk binding
,null,
Proceedings of the National Academy of Sciences of the United States of America
,PubMed ID 20133761
[CDKN1B]
|
|
Discovery of a distinct domain in cyclin A sufficient for centrosomal localization independently of Cdk binding
,Gaetan Pascreau, Frank Eckerdt, Mair E. A. Churchill, and James L. Maller,
PNAS, Feb 2010; 107: 2932 - 2937
[CDKN1B]
|
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC201661 | CDKN1B (Myc-DDK-tagged)-Human cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B) |
CNY 3,600.00 |
|
| RC201661L1 | Lenti ORF clone of Human cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B), Myc-DDK-tagged |
CNY 6,000.00 |
|
| RC201661L2 | Lenti ORF clone of Human cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B), mGFP tagged |
CNY 5,890.00 |
|
| RC201661L3 | Lenti ORF clone of Human cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B), Myc-DDK-tagged |
CNY 6,000.00 |
|
| RC201661L4 | Lenti ORF clone of Human cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B), mGFP tagged |
CNY 6,000.00 |
|
| RG201661 | CDKN1B (tGFP-tagged) - Human cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B) |
CNY 5,200.00 |
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