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STAT5A (NM_003152) Human Untagged Clone
CAT＃: SC118194
STAT5A (untagged)-Human signal transducer and activator of transcription 5A (STAT5A)
CNY 14,760.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | MGF; STAT5 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_003152, the custom clone sequence may differ by one or more nucleotides
TCGGCACGAGGCCGCCAGGAACCCCGGCCGGGAGCGAGAGCCGCGGGGCGCAGAGCCGGCCCGGCTGCCG GACGGTGCGGCCCCACCAGGTGAACGGCCATGGCGGGCTGGATCCAGGCCCAGCAGCTGCAGGGAGACGC GCTGCGCCAGATGCAGGTGCTGTACGGCCAGCACTTCCCCATCGAGGTCCGGCACTACTTGGCCCAGTGG ATTGAGAGCCAGCCATGGGATGCCATTGACTTGGACAATCCCCAGGACAGAGCCCAAGCCACCCAGCTCC TGGAGGGCCTGGTGCAGGAGCTGCAGAAGAAGGCGGAGCACCAGGTGGGGGAAGATGGGTTTTTACTGAA GATCAAGCTGGGGCACTACGCCACGCAGCTCCAGAAAACATATGACCGCTGCCCCCTGGAGCTGGTCCGC TGCATCCGGCACATTCTGTACAATGAACAGAGGCTGGTCCGAGAAGCCAACAATTGCAGCTCTCCGGCTG GGATCCTGGTTGACGCCATGTCCCAGAAGCACCTTCAGATCAACCAGACATTTGAGGAGCTGCGACTGGT CACGCAGGACACAGAGAATGAGCTGAAGAAACTGCAGCAGACTCAGGAGTACTTCATCATCCAGTACCAG GAGAGCCTGAGGATCCAAGCTCAGTTTGCCCAGCTGGCCCAGCTGAGCCCCCAGGAGCGTCTGAGCCGGG AGACGGCCCTCCAGCAGAAGCAGGTGTCTCTGGAGGCCTGGTTGCAGCGTGAGGCACAGACACTGCAGCA GTACCGCGTGGAGCTGGCCGAGAAGCACCAGAAGACCCTGCAGCTGCTGCGGAAGCAGCAGACCATCATC CTGGATGACGAGCTGATCCAGTGGAAGCGGCGGCAGCAGCTGGCCGGGAACGGCGGGCCCCCCGAGGGCA GCCTGGACGTGCTACAGTCCTGGTGTGAGAAGTTGGCCGAGATCATCTGGCAGAACCGGCAGCAGATCCG CAGGGCTGAGCACCTCTGCCAGCAGCTGCCCATCCCCGGCCCAGTGGAGGAGATGCTGGCCGAGGTCAAC GCCACCATCACGGACATTATCTCAGCCCTGGTGACCAGCACATTCATCATTGAGAAGCAGCCTCCTCAGG TCCTGAAGACCCAGACCAAGTTTGCAGCCACCGTACGCCTGCTGGTGGGCGGGAAGCTGAACGTGCACAT GAATCCCCCCCAGGTGAAGGCCACCATCATCAGTGAGCAGCAGGCCAAGTCTCTGCTTAAAAATGAGAAC ACCCGCAACGAGTGCAGTGGTGAGATCCTGAACAACTGCTGCGTGATGGAGTACCACCAAGCCACGGGCA CCCTCAGTGCCCACTTCAGGAACATGTCACTGAAGAGGATCAAGCGTGCTGACCGGCGGGGTGCAGAGTC CGTGACAGAGGAGAAGTTCACAGTCCTGTTTGAGTCTCAGTTCAGTGTTGGCAGCAATGAGCTTGTGTTC CAGGTGAAGACTCTGTCCCTACCTGTGGTTGTCATCGTCCACGGCAGCCAGGACCACAATGCCACGGCTA CTGTGCTGTGGGACAATGCCTTTGCTGAGCCGGGCAGGGTGCCATTTGCCGTGCCTGACAAAGTGCTGTG GCCGCAGCTGTGTGAGGCGCTCAACATGAAATTCAAGGCCGAAGTGCAGAGCAACCGGGGCCTGACCAAG GAGAACCTCGTGTTCCTGGCGCAGAAACTGTTCAACAACAGCAGCAGCCACCTGGAGGACTACAGTGGCC TGTCCGTGTCCTGGTCCCAGTTCAACAGGGAGAACTTGCCGGGCTGGAACTACACCTTCTGGCAGTGGTT TGACGGGGTGATGGAGGTGTTGAAGAAGCACCACAAGCCCCACTGGAATGATGGGGCCATCCTAGGTTTT GTGAATAAGCAACAGGCCCACGACCTGCTCATCAACAAGCCCGACGGGACCTTCTTGTTGCGCTTTAGTG ACTCAGAAATCGGGGGCATCACCATCGCCTGGAAGTTTGACTCCCCGGAACGCAACCTGTGGAACCTGAA ACCATTCACCACGCGGGATTTCTCCATCAGGTCCCTGGCTGACCGGCTGGGGGACCTGAGCTATCTCATC TATGTGTTTCCTGACCGCCCCAAGGATGAGGTCTTCTCCAAGTACTACACTCCTGTGCTGGCTAAAGCTG TTGATGGATATGTGAAACCACAGATCAAGCAAGTGGTCCCTGAGTTTGTGAATGCATCTGCAGATGCTGG GGGCAGCAGCGCCACGTACATGGACCAGGCCCCCTCCCCAGCTGTGTGCCCCCAGGCTCCCTATAACATG TACCCACAGAACCCTGACCATGTACTCGATCAGGATGGAGAATTCGACCTGGATGAGACCATGGATGTGG CCAGGCACGTGGAGGAACTCTTACGCCGACCAATGGACAGTCTTGACTCCCGCCTCTCGCCCCCTGCCGG TCTTTTCACCTCTGCCAGAGGCTCCCTCTCATGAATGTTTGAATCCCACGCTTCTCTTTGGAAACAATAT GCAATGTGAAGCGGTCGTGTTGTGAGTTTAGTAAGGCTGTGTACACTGACACCTTTGCAGGCATTCGGCA CGAGGCCGCCAGGAACCCCGGCCGGGAGCGAGAGCCGCGGGGCGCAGAGCCGGCCCGGCTGCCGGACGGT GCGGCCCCACCAGGTGAACGGCCATGGCGGGCTGGATCCAGGCCCAGCAGCTGCAGGGAGACGCGCTGCG CCAGATGCAGGTGCTGTACGGCCAGCACTTCCCCATCGAGGTCCGGCACTACTTGGCCCAGTGGATTGAG AGCCAGCCATGGGATGCCATTGACTTGGACAATCCCCAGGACAGAGCCCAAGCCACCCAGCTCCTGGAGG GCCTGGTGCAGGAGCTGCAGAAGAAGGCGGAGCACCAGGTGGGGGAAGATGGGTTTTTACTGAAGATCAA GCTGGGGCACTACGCCACGCAGCTCCAGAAAACATATGACCGCTGCCCCCTGGAGCTGGTCCGCTGCATC CGGCACATTCTGTACAATGAACAGAGGCTGGTCCGAGAAGCCAACAATTGCAGCTCTCCGGCTGGGATCC TGGTTGACGCCATGTCCCAGAAGCACCTTCAGATCAACCAGACATTTGAGGAGCTGCGACTGGTCACGCA GGACACAGAGAATGAGCTGAAGAAACTGCAGCAGACTCAGGAGTACTTCATCATCCAGTACCAGGAGAGC CTGAGGATCCAAGCTCAGTTTGCCCAGCTGGCCCAGCTGAGCCCCCAGGAGCGTCTGAGCCGGGAGACGG CCCTCCAGCAGAAGCAGGTGTCTCTGGAGGCCTGGTTGCAGCGTGAGGCACAGACACTGCAGCAGTACCG CGTGGAGCTGGCCGAGAAGCACCAGAAGACCCTGCAGCTGCTGCGGAAGCAGCAGACCATCATCCTGGAT GACGAGCTGATCCAGTGGAAGCGGCGGCAGCAGCTGGCCGGGAACGGCGGGCCCCCCGAGGGCAGCCTGG ACGTGCTACAGTCCTGGTGTGAGAAGTTGGCCGAGATCATCTGGCAGAACCGGCAGCAGATCCGCAGGGC TGAGCACCTCTGCCAGCAGCTGCCCATCCCCGGCCCAGTGGAGGAGATGCTGGCCGAGGTCAACGCCACC ATCACGGACATTATCTCAGCCCTGGTGACCAGCACATTCATCATTGAGAAGCAGCCTCCTCAGGTCCTGA AGACCCAGACCAAGTTTGCAGCCACCGTACGCCTGCTGGTGGGCGGGAAGCTGAACGTGCACATGAATCC CCCCCAGGTGAAGGCCACCATCATCAGTGAGCAGCAGGCCAAGTCTCTGCTTAAAAATGAGAACACCCGC AACGAGTGCAGTGGTGAGATCCTGAACAACTGCTGCGTGATGGAGTACCACCAAGCCACGGGCACCCTCA GTGCCCACTTCAGGAACATGTCACTGAAGAGGATCAAGCGTGCTGACCGGCGGGGTGCAGAGTCCGTGAC AGAGGAGAAGTTCACAGTCCTGTTTGAGTCTCAGTTCAGTGTTGGCAGCAATGAGCTTGTGTTCCAGGTG AAGACTCTGTCCCTACCTGTGGTTGTCATCGTCCACGGCAGCCAGGACCACAATGCCACGGCTACTGTGC TGTGGGACAATGCCTTTGCTGAGCCGGGCAGGGTGCCATTTGCCGTGCCTGACAAAGTGCTGTGGCCGCA GCTGTGTGAGGCGCTCAACATGAAATTCAAGGCCGAAGTGCAGAGCAACCGGGGCCTGACCAAGGAGAAC CTCGTGTTCCTGGCGCAGAAACTGTTCAACAACAGCAGCAGCCACCTGGAGGACTACAGTGGCCTGTCCG TGTCCTGGTCCCAGTTCAACAGGGAGAACTTGCCGGGCTGGAACTACACCTTCTGGCAGTGGTTTGACGG GGTGATGGAGGTGTTGAAGAAGCACCACAAGCCCCACTGGAATGATGGGGCCATCCTAGGTTTTGTGAAT AAGCAACAGGCCCACGACCTGCTCATCAACAAGCCCGACGGGACCTTCTTGTTGCGCTTTAGTGACTCAG AAATCGGGGGCATCACCATCGCCTGGAAGTTTGACTCCCCGGAACGCAACCTGTGGAACCTGAAACCATT CACCACGCGGGATTTCTCCATCAGGTCCCTGGCTGACCGGCTGGGGGACCTGAGCTATCTCATCTATGTG TTTCCTGACCGCCCCAAGGATGAGGTCTTCTCCAAGTACTACACTCCTGTGCTGGCTAAAGCTGTTGATG GATATGTGAAACCACAGATCAAGCAAGTGGTCCCTGAGTTTGTGAATGCATCTGCAGATGCTGGGGGCAG CAGCGCCACGTACATGGACCAGGCCCCCTCCCCAGCTGTGTGCCCCCAGGCTCCCTATAACATGTACCCA CAGAACCCTGACCATGTACTCGATCAGGATGGAGAATTCGACCTGGATGAGACCATGGATGTGGCCAGGC ACGTGGAGGAACTCTTACGCCGACCAATGGACAGTCTTGACTCCCGCCTCTCGCCCCCTGCCGGTCTTTT CACCTCTGCCAGAGGCTCCCTCTCATGAATGTTTGAATCCCACGCTTCTCTTTGGAAACAATATGCAATG TGAAGCGGTCGTGTTGTGAGTTTAGTAAGGCTGTGTACACTGACACCTTTGCAGGCAT >OriGene 5' read for NM_003152 unedited
CTTTCCCCCGCCCGTTGNCGCATAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAG CAGAGCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGCG AATTCGGCACGAGGCCGCCAGGAACCCCGGCCGGGAGCGAGAGCCGCGGGGCGCAGAGCC GGCCCGGCTGCCGGACGGTGCGGCCCCACCAGGTGAACGGCCATGGCGGGCTGGATCCAG GCCCAGCAGCTGCAGGGAGACGCGCTGCGCCAGATGCAGGTGCTGTACGGCCAGCACTTC CCCATCGAGGTCCGGCACTACTTGGCCCAGTGGATTGAGAGCCAGCCATGGGATGCCATT GACTTGGACAATCCCCAGGACAGAGCCCAAGCCACCCAGCTCCTGGAGGGCCTGGTGCAG GAGCTGCAGAAGAAGGCGGAGCACCAGGTGGGGGAAGATGGGTTTTTACTGAAGATCAAG CTGGGGCACTACGCCACGCAGCTCCAGAAAACATATGACCGCTGCCCCCTGGAGCTGGTC CGCTGCATCCGGCACATTCTGTACAATGAACAGAGGCTGGTCCGAGAAGCCAACAATTGC AGCTCTCCGGCTGGGATCCTGGTTGACGCCATGTCCCAGAAGCACCTTCAGATCAACCAG ACATTTGAGGAGCTGCGACTGGTCACGCAGGACACAGAGAATGAGCTGAAGAAACTGCAG CAGACTCAGGAGTACTTCATCATCCAGTACCAGGAGAGCCTGANGATCCAAGCTCAGTTT GCCCAGCTGGGCCAGCTGAGCCCCCAGGAGCGTCTGAGCCAGGAGACGGCCCTNCAGCAG AAGCAGGTGTCTCTGGNAGCCCTGGNTGCAGCGTGAGCACAGACACTGCAGCAGTACCGC GTGGAGCTGGCCGAGAAGCACAGAAGACCCTGCAGCTGCTGCGGAAGCAGCAGACATCAT CC >OriGene 3' read for NM_003152 unedited
CGTACACTATGNACCGCGCCGCATCTATGATCGGTTTTTTTTTTTTTTTTTTATGAAAAA AAATTTTATTCCAAAACACTGTTTACACAAATGTGTGGTCTTTGTACAAAGTACAAAAAA ACCCCTCTTCTCATCCCCACCTCCCTTCAGAGAAGTTTAAACCTTGGGCTCTCAATCTTC CATGGTCAGCTGCCCCTGACTGCGAGTCCTACAGCCTCAGAGGGAGGAGCGTGTGGGGTT GGGAGCAAGGCCTCACCAGAACACAGCCAGTTACGCAACAGCGCAAGGCCTGCTCCAGGC CCCACCTCCAGCGGAGTCAAACCAGATCAGCTTTTACCCCTCACTCCAGATTCCACAGGC ACGCAGCACATGGCTGATTTGCAGCTTGTCTTTCACTGCAGTTTTTTGTTTTTGTTTTTT CCAGGAGGCAAGAGGACCAACCCTCCAAGTCCCGGGGCCCCTGTCCACCACCATATCCTA GACCCAATCTTTTCTACCTCTTTGTCGACAAGGTTACAAACAGAGAGGCAAGCAAAGAAT GCTGGGGCCCAACGGAGGGGAGAGAATATATATCCCGGGAAACGTGGGCAACAGCATCAT AGACTTGAATGAAGCCCAAGGCCAAGCAGCCAAGCAAGGACTAATTCAGAGCAGCTCAGA AACCCTCACTCAAACAGGCGGCCCCCCCTGTGCTAAAGACATGGGCCGGGCCCCAGACGC GCTCTCATAGGGTCCACAGAGAGTCTGGAGTCCACCGTCACTAAAGTATAAAAATACTAC TCGAAAATGAACCCCCAGCCTCCCCTTCTGAAGAGATGAAATCGGTTACTTCCAACCCCT TGAAGACCGAATGCGTTTTTCTTAGGACCCCCCCACTTCTTTCTTTGGTGTGTGTTG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_003152 |
| Insert Size | 4000 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_003152.2, NP_003143.2 |
| RefSeq Size | 4314 bp |
| RefSeq ORF | 4314 bp |
| Locus ID | 6776 |
| UniProt ID | P42229 |
| Domains | SH2, STAT |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Stem cell relevant signaling - JAK/STAT signaling pathway, Transcription Factors |
| Protein Pathways | Acute myeloid leukemia, Chronic myeloid leukemia, ErbB signaling pathway, Jak-STAT signaling pathway, Pathways in cancer |
| Gene Summary | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013] Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
STAT5A-mediated NOX5-L expression promotes the proliferation and metastasis of breast cancer cells
,Dho, SH;Kim, JY;Lee, KP;Kwon, ES;Lim, JC;Kim, CJ;Jeong, D;Kwon, KS;,
Exp. Cell Res
,PubMed ID 28034671
[STAT5A]
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| RC205753L2 | Lenti-ORF clone of STAT5A (mGFP-tagged)-Human signal transducer and activator of transcription 5A (STAT5A) |
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| RC205753L3 | Lenti-ORF clone of STAT5A (Myc-DDK-tagged)-Human signal transducer and activator of transcription 5A (STAT5A) |
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| RC205753L4 | Lenti-ORF clone of STAT5A (mGFP-tagged)-Human signal transducer and activator of transcription 5A (STAT5A) |
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| RG205753 | STAT5A (tGFP-tagged) - Human signal transducer and activator of transcription 5A (STAT5A) |
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