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PI 3 Kinase Class 3 (PIK3C3) (NM_002647) Human Untagged Clone
CAT＃: SC118487
PIK3C3 (untagged)-Human phosphoinositide-3-kinase, class 3 (PIK3C3)
CNY 6,504.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | hVps34; VPS34; Vps34 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC118487 sequence for NM_002647 edited (data generated by NextGen Sequencing)
ATGGGGGAAGCAGAGAAGTTTCACTACATCTATAGTTGTGACCTGGATATCAACGTCCAG CTTAAGATAGGAAGCTTGGAAGGGAAGAGAGAACAAAAGAGTTATAAAGCTGTCCTGGAA GACCCAATGTTGAAGTTCTCAGGACTATATCAAGAGACATGCTCTGATCTTTATGTTACT TGTCAAGTTTTTGCAGAAGGGAAGCCTTTGGCCTTGCCAGTGAGAACATCCTACAAAGCA TTTAGTACAAGATGGAACTGGAATGAATGGCTGAAACTACCAGTAAAATACCCTGACCTG CCCAGGAATGCCCAAGTGGCCCTCACCATATGGGATGTGTATGGTCCCGGAAAAGCAGTG CCTGTAGGAGGAACAACGGTTTCGCTCTTTGGAAAATACGGCATGTTTCGCCAAGGGATG CATGACTTGAAAGTCTGGCCTAATGTAGAAGCAGATGGATCAGAACCCACAAAAACTCCT GGCAGAACAAGTAGCACTCTCTCAGAAGATCAGATGAGCCGTCTTGCCAAGCTCACCAAA GCTCATCGACAAGGACACATGGTGAAAGTAGATTGGCTGGATAGATTGACATTTAGAGAA ATAGAAATGATAAATGAGAGTGAAAAACGAAGTTCTAATTTCATGTACCTGATGGTTGAA TTTCGATGTGTCAAGTGTGATGATAAGGAATATGGTATTGTTTATTATGAAAAGGACGGT GATGAATCATCTCCAATTTTAACAAGTTTTGAATTAGTGAAAGTTCCTGACCCCCAGATG TCTATGGAGAATTTAGTTGAGAGCAAACACCACAAGCTTGCCCGGAGTTTAAGAAGTGGA CCTTCTGACCACGATCTGAAACCCAATGCTGCCACGAGAGATCAGTTAAATATTATTGTG AGTTATCCACCAACCAAGCAACTTACATATGAAGAACAAGATCTTGTTTGGAAGTTTAGA TATTATCTTACGAATCAAGAAAAAGCCTTGACAAAATTCTTGAAATGTGTTAATTGGGAT CTACCTCAAGAGGCCAAACAGGCCTTGGAACTTCTGGGAAAATGGAAGCCGATGGATGTA GAGGACTCCTTGGAGCTGTTATCCTCTCATTACACCAACCCAACTGTGAGGCGTTATGCT GTTGCCCGGTTGCGACAGGCCGATGATGAGGATTTGTTGATGTACCTATTACAATTGGTC CAGGCTCTCAAATATGAAAATTTTGATGATATAAAGAATGGATTGGAACCTACCAAGAAG GATAGTCAGAGTTCAGTGTCAGAAAATGTGTCAAATTCTGGAATAAATTCTGCAGAAATA GATAGCTCCCAAATTATAACCAGCCCCCTTCCTTCAGTCTCTTCACCTCCTCCTGCATCA AAAACAAAAGAAGTTCCAGATGGCGAAAATCTGGAACAAGATCTCTGTACCTTCTTGATA TCGAGAGCCTGCAAAAACTCAACACTGGCTAATTATTTATACTGGTATGTGATAGTGGAA TGTGAAGATCAAGATACTCAGCAGAGAGATCCAAAGACCCATGAGATGTACTTGAACGTA ATGAGAAGATTCAGCCAAGCATTGTTGAAGGGTGATAAGTCTGTCAGAGTTATGCGTTCT TTGCTGGCTGCACAACAGACATTTGTAGATCGGTTGGTGCATCTAATGAAGGCAGTACAA CGCGAAAGTGGAAATCGTAAGAAAAAGAATGAGAGACTACAGGCATTGCTTGGAGATAAT GAAAAGATGAATTTGTCAGATGTGGAACTTATCCCGTTGCCTTTAGAACCCCAAGTGAAA ATTAGAGGAATAATTCCGGAAACAGCTACACTGTTTAAAAGTGCCCTTATGCCTGCACAG TTGTTTTTTAAGACGGAAGATGGAGGCAAATATCCAGTTATATTTAAGCATGGAGATGAT TTACGTCAAGATCAACTTATTCTTCAAATCATTTCACTCATGGACAAGCTGTTACGGAAA GAAAATCTGGACTTGAAATTGACACCTTATAAGGTGTTAGCCACCAGTACAAAACATGGC TTCATGCAGTTTATCCAGTCAGTTCCTGTGGCTGAAGTTCTTGATACAGAGGGAAGCATT CAGAACTTTTTTAGAAAATATGCACCAAGTGAGAATGGGCCAAATGGGATTAGTGCTGAG GTCATGGACACTTACGTTAAAAGCTGTGCTGGATATTGCGTGATCACCTATATACTTGGA GTTGGAGACAGGCACCTGGATAACCTTTTGCTAACAAAAACAGGCAAACTCTTCCACATA GACTTTGGATATATTTTGGGTCGGGATCCAAAGCCTCTTCCTCCACCAATGAAGCTGAAT AAAGAAATGGTAGAAGGAATGGGGGGCACACAGAGTGAGCAGTACCAAGAGTTCCGTAAA CAGTGTTACACGGCTTTCCTCCACCTGCGAAGGTATTCTAATCTGATTTTGAACTTGTTT TCCTTGATGGTTGATGCAAACATTCCAGATATTGCACTTGAACCAGATAAAACTGTGAAA AAGGTTCAGGATAAATTCCGCTTAGACCTGTCGGATGAAGAGGCTGTGCATTACATGCAG AGTCTGATTGATGAGAGTGTCCATGCTCTTTTTGCTGCAGTGGTGGAACAGATTCACAAG TTTGCCCAGTACTGGAGAAAATGA Clone variation with respect to NM_002647.2 >OriGene 5' read for NM_002647 unedited
GGGCAGAATTTTGGTATACGACTCACTATAGGGCGGCCGCGNAATTCGCACGAGGGTTCA TTTATGTTGTTTTTCCTGTACCTAAGTTCCCGCTGTAGGTGGTACCTTTGCAGACGGTGC GATGGGGGAAGCAGAGAAGTTTCACTACATCTATAGTTGTGACCTGGATATCAACGTCCA GCTTAAGATAGGAAGCTTGGAAGGGAAGAGAGAACAAAAGAGTTATAAAGCTGTCCTGGA AGACCCAATGTTGAAGTTCTCAGGACTATATCAAGAGACATGCTCTGATCTTTATGTTAC TTGTCAAGTTTTTGCAGAAGGGAAGCCTTTGGCCTTGCCAGTGAGAACATCCTACAAAGC ATTTAGTACAAGATGGAACTGGAATGAATGGCTGAAACTACCAGTAAAATACCCTGACCT GCCCAGGAATGCCCAAGTGGCCCTCACCATATGGGATGTGTATGGTCCCGGAAAAGCAGT GCCTGTAGGAGGAACAACGGTTTCGCTCTTTGGAAAATACGGCATGTTTCGCCAAGGGAT GCATGACTTGAAAGTCTGGCCTAATGTAGAAGCAGATGGATCAGAACCCACAAAAACTCC TGGCAGAACAAGTAGCACTCTCTCAGAAGATCAGATGAGCCGTCTTGCCAAGCTCACCAA AGCTCATCGACAAGGACACATGGTGAAAGTAGATTGGCTGGATAGATTGACATTTAGAGA AATAGAAATGATAAATGAGAGTGAAAAACGAAGTTCTAATTTCATGTACCTGATGGTTGA ATTTCGATGTGTCAAGTGTGATGATAAGGGATATGGTATTGTTTATTATGAAAAGGACGG TGATGAATCATCTNCAATTTTAAACAGTTTGAAATANTGAAAGTTCCTGACCCCCAATGT CTATGAGAATTAGTTGAGAG >OriGene 3' read for NM_002647 unedited
CGCGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTGTTTCTCATTTCTTAATTT ATTAACAATGTATACATTTGAAAAAAATATACAATATTTCAAAACAAGCCCTTCAAGACT ATATTTAAGCAATGACATCCAAGGAAGCAGAACTCAGGTACCATGTAATATTTGGAAAAT ATGGTAACTTGAAGATTAAGATTTCTCTTCCTTGCTGGTTACTCTGAAGTCTCCAATATA CAAAGGTTGCTCCTAACGTGGTTTTCTTATTGAGCCAAGCATCTTGATGGGTCAATCCCA GTTTCATTTTCTCCAGTACTGGGCAAACTTGTGAATCTGTTCCACCACTGCAGCAAAAAG AGCATGGACACTCTCATCAATCAGACTCTGCATGTAATGCACAGCCTCTTCATCCGACAG GTCTAAGCGGAATTTATCCTGAACCTTTTTCACAGTTTTATCTGGTTCAAGTGCAATATC TGGAATGTTTGCATCAACCATCAAGGAAAACAAGTTCAAAATCAGATTAGAATACCTTCG CAGGTGGAGGAAAGCCGGGTAACACTGTTTACGGAACTCTTGGTACTGCTCACTCTGTGT GCCCCCCATTCCTTTTACCATTTCTTTATTCACCTTCATTGGTGGAGGAAAGAGCTTTGG ATCCCGACCCAAATATTTCCAAGTCTATCGGGAAAAGTTGCCTGTTTTGCTACAAAAGGT ATCCAGTGGCTGTCTCTACTCCAGTTTTTTGGATCACCCACTTTCCCCCACCTCTTACGA AGTGTCCTTGACCTCCCTTTTCCATTTGCCCTTCTCACTGGGGCTTTTTTAAAAAGTCTG AAGCCTCCTCGTTCAAGAATTTCCCCAGGAATGACGTAAATGCTTAACCTGTTTGTCCGG GGGTAACCTTAAGGGCA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002647 |
| Insert Size | 3420 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002647.2, NP_002638.2 |
| RefSeq Size | 3083 bp |
| RefSeq ORF | 2664 bp |
| Locus ID | 5289 |
| UniProt ID | Q8NEB9 |
| Domains | PI3_PI4_kinase, PI3Ka, PI3K_C2 |
| Protein Families | Druggable Genome |
| Protein Pathways | Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, Regulation of autophagy |
| Gene Summary | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria
,Mbengue, A;Bhattacharjee, S;Pandharkar, T;Liu, H;Estiu, G;Stahelin, RV;Rizk, SS;Njimoh, DL;Ryan, Y;Chotivanich, K;Nguon, C;Ghorbal, M;Lopez-Rubio, JJ;Pfrender, M;Emrich, S;Mohandas, N;Dondorp, AM;Wiest, O;Haldar, K;,
Nature
,PubMed ID 25874676
[PIK3C3]
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Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC205317 | PIK3C3 (Myc-DDK-tagged)-Human phosphoinositide-3-kinase, class 3 (PIK3C3) |
CNY 6,496.00 |
|
| RC205317L1 | Lenti ORF clone of Human phosphoinositide-3-kinase, class 3 (PIK3C3), Myc-DDK-tagged |
CNY 8,896.00 |
|
| RC205317L2 | Lenti ORF clone of Human phosphoinositide-3-kinase, class 3 (PIK3C3), mGFP tagged |
CNY 9,030.00 |
|
| RC205317L3 | Lenti ORF clone of Human phosphoinositide-3-kinase, class 3 (PIK3C3), Myc-DDK-tagged |
CNY 9,030.00 |
|
| RC205317L4 | Lenti ORF clone of Human phosphoinositide-3-kinase, class 3 (PIK3C3), mGFP tagged |
CNY 9,030.00 |
|
| RG205317 | PIK3C3 (tGFP-tagged) - Human phosphoinositide-3-kinase, class 3 (PIK3C3) |
CNY 8,096.00 |
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