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uPA (PLAU) (NM_002658) Human Untagged Clone
CAT＃: SC118493
PLAU (untagged)-Human plasminogen activator, urokinase (PLAU), transcript variant 1
CNY 5,488.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ATF; BDPLT5; QPD; u-PA; UPA; URK |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_002658 edited
GAATTCGGCACGAGGGCAGCCCCGGAGCCCGGGCCAGGGTCCACCTGTCCCCGCAGCGCC GGCTCGCGCCCTCCTGCCGCAGCCACCGAGCCGCCGTCTAGCGCCCCGACCTCGCCACCA TGAGAGCCCTGCTGGCGCGCCTGCTTCTCTGCGTCCTGGTCGTGAGCGACTCCAAAGGCA GCAATGAACTTCATCAAGTTCCATCGAACTGTGACTGTCTAAATGGAGGAACATGTGTGT CCAACAAGTACTTCTCCAACATTCACTGGTGCAACTGCCCAAAGAAATTCGGAGGGCAGC ACTGTGAAATAGATAAGTCAAAAACCTGCTATGAGGGGAATGGTCACTTTTACCGAGGAA AGGCCAGCACTGACACCATGGGCCGGCCCTGCCTGCCCTGGAACTCTGCCACTGTCCTTC AGCAAACGTACCATGCCCACAGATCTGATGCTCTTCAGCTGGGCCTGGGGAAACATAATT ACTGCAGGAACCCAGACAACCGGAGGCGACCCTGGTGCTATGTGCAGGTGGGCCTAAAGC CGCTTGTCCAAGAGTGCATGGTGCATGACTGCGCAGATGGAAAAAAGCCCTCCTCTCCTC CAGAAGAATTAAAATTTCAGTGTGGCCAAAAGACTCTGAGGCCCCGCTTTAAGATTATTG GGGGAGAATTCACCACCATCGAGAACCAGCCCTGGTTTGCGGCCATCTACAGGAGGCACC GGGGGGGCTCTGTCACCTACGTGTGTGGAGGCAGCCTCATCAGCCCTTGCTGGGTGATCA GCGCCACACACTGCTTCATTGATTACCCAAAGAAGGAGGACTACATCGTCTACCTGGGTC GCTCAAGGCTTAACTCCAACACGCAAGGGGAGATGAAGTTTGAGGTGGAAAACCTCATCC TACACAAGGACTACAGCGCTGACACGCTTGCTCACCACAACGACATTGCCTTGCTGAAGA TCCGTTCCAAGGAGGGCAGGTGTGCGCAGCCATCCCGGACTATACAGACCATCTGCCTGC CCTCGATGTATAACGATCCCCAGTTTGGCACAAGCTGTGAGATCACTGGCTTTGGAAAAG AGAATTCTACCGACTATCTCTATCCGGAGCAGCTGAAAATGACTGTTGTGAAGCTGATTT CCCACCGGGAGTGTCAGCAGCCCCACTACTACGGCTCTGAAGTCACCACCAAAATGCTGT GTGCTGCTGACCCACAGTGGAAAACAGATTCCTGCCAGGGAGACTCAGGGGGACCCCTCG TCTGTTCCCTCCAAGGCCGCATGACTTTGACTGGAATTGTGAGCTGGGGCCGTGGATGTG CCCTGAAGGACAAGCCAGGCGTCTACACGAGAGTCTCACACTTCTTACCCTGGATCCGCA GTCACACCAAGGAAGAGAATGGCCTGGCCCTCTGAGGGTCCCCAGGGAGGAAACGGGCAC CACCCGCTTTCTTGCTGGTTGTCATTTTTGCAGTAGAGTCATCTCCATCAGCTGTAAGAA GAGACTGGGAAGATAGGCTCTGCACAGATGGATTTGCCTGTGCCACCCACCAGGGTGAAC GACAATAGCTTTACCCTCAGGCATAGGCCTGGGTGCTGGCTGCCCAGACCCCTCTGGCCA GGATGGAGGGGTGGTCCTGACTCAACATGTTACTGACCAGCAACTTGTCTTTTTCTGGAC TGAAGCCTGCAGGAGTTAAAAAGGGCAGGGCATCTCCTGTGCATGGGTGAAGGGAGAGCC AGCTCCCCCGACGGTGGGCATTTGTGAGGCCCATGGTTGAGAAATGAATAATTTCCCAAT TAGGAAGTGTAACAGCTGAGGTCTCTTGAGGGAGCTTAGCCAATGTGGGAGCAGCGGTTT GGGGAGCAGAGACACTAACGACTTCAGGGCAGGGCTCTGATATTCCATGAATGTATCAGG AAATATATATGTGTGTGTATGTTTGCACACTTGTGTGTGGGCTGTGAGTGTAAGTGTGAG TAAGAGCTGGTGTCTGATTGTTAAGTCTAAATATTTCCTTAAACTGTGTGGACTGTGATG CCACACAGAGTGGTCTTTCTGGAGAGGTTATAGGTCACTCCTGGGGCCTCTTGGGTCCCC CACGTGACAGTGCCTGGGAATGTATTATTCTGCAGCATGACCTGTGACCAGCACTGTCTC AGTTTCACTTTCACATAGATGTCCCTTTCTTGGCCAGTTATCCCTTCCTTTTAGCCTAGT TCATCCAATCCTCACTGGGTGGGGTGAGGACCACTCCTTACACTGAATATTTATATTTCA CTATTTTTATTTATATTTTTGTAATTTTAAATAAAAGTGATCAATAAXXXXXXXXXXXXX AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_002658 unedited
TTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGCAGCCCCGGAGCCC GGGCCAGGGTCCACCTGTCCCCGCAGCGCCGGCTCGCGCCCTCCTGCCGCAGCCACCGAG CCGCCGTCTAGCGCCCCGACCTCGCCACCATGAGAGCCCTGCTGGCGCGCCTGCTTCTCT GCGTCCTGGTCGTGAGCGACTCCAAAGGCAGCAATGAACTTCATCAAGTTCCATCGAACT GTGACTGTCTAAATGGAGGAACATGTGTGTCCAACAAGTACTTCTCCAACATTCACTGGT GCAACTGCCCAAAGAAATTCGGAGGGCAGCACTGTGAAATAGATAAGTCAAAAACCTGCT ATGAGGGGAATGGTCACTTTTACCGAGGAAAGGCCAGCACTGACACCATGGGCCGGCCCT GCCTGCCCTGGAACTCTGCCACTGTCCTTCAGCAAACGTACCATGCCCACAGATCTGATG CTCTTCAGCTGGGCCTGGGGAAACATAATTACTGCAGGAACCCAGACAACCGGAGGCGAC CCTGGTGCTATGTGCAGGTGGGCCTAAAGCCGCTTGTCCAAGAGTGCATGGTGCATGACT GCGCAGATGGAAAAAAGCCCTCCTCTCCTCCAGAAGAATTAANATTTCAGTGTGGCCAAA AGACTCTGACGCCCCCGCTNTAAGAATATTGGGGGAGAATTCACCACCATCGAGAACCAG CCCTGGTTTGCGGNCATCTACAGGAGGCACCGGGNGGGGCTCTGTCACCTACGTGTGTGG AGGCAGCCTCATCAGCCCTTGCTGGGTGATCAGCGGCACACACTGCTTCATTGATTACCC CAAGAGGAGGACTACATCGTCTACCTGGGTCGCTCAAGGCTTACTCCACACGCAAGGG >OriGene 3' read for NM_002658 unedited
GGAGCGCGCGCGCCCCACCACNAAACACACCCCCNNNNNANNNGNATTTTTCGTNAAAAT ACACATTTTNTATGNTNCACNNTTTTATTTAAAATTACCAAAAATATTAAANNNAAAAAT AGTGAAATATAAATATTCAGTGTAAGGAGTGGTCCTCACCCCACCCAGTGAGGATTGGAT GAACTAGGCTAAAAGGAAGGGATAACTGGCCAAGAAAGGGACATCTATGTGAAAGTGAAA CTGAGACAGTGCTGGTCACAGGTCATGCTGCAGAATAATACATTCCCAGGCACTGTCACG TGGGGGACCCAAGAGGCCCCAGGAGTGACCTATAACCTCTCCAGAAAGACCACTCTGTGT GGCATCACAGTCCACACAGTTTAAGGAAATATTTAGACTTAACAATCAGACACCAGCTCT TACTCACACTTACACTCACAGCCCACACACAAGTGTGCAAACATACACACACATATATAT TTCCTGATACATTCATGGAATATCAGAGCCCTGCCCTGAAGTCGTTAGTGTCTCTGCTCC CCAAACCGCTGCTCCCACATTGGCTAAGCTCCCTCAAGAGACCTCAGCTGTTACACTTCC TAATTGGGAAATTATTCATTTCTCAACCATGGGCCTCACAAATGCCCACCGTCGGGGGAG CTGGCTCTCCCTTCACCCATGCACAGGAGATGCCCTGCCCTTTTTAACTCCTGCAAGCTT CAGTCCAGAAAAAGACAAGTTGCTGGTCAGTAACATGTTGAGTCAAGACCACCCCTCCAT CCTGGCCAGAGGGGTCTTGGGCAGCCAGCACCCAGGCCTATGCCTGAAGGTAAAGCTATT GTCGTTCACCCTGGTGGGTGGGCACAGGCAAATCCATTTGTGGCAAACCCTATCTTCCAA ATCTCTTCTTTACAACTGATGGAGTAGACTCTTCTGCAAAAATGACCACCACCAG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002658 |
| Insert Size | 2560 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002658.2, NP_002649.1 |
| RefSeq Size | 2360 bp |
| RefSeq ORF | 1296 bp |
| Locus ID | 5328 |
| UniProt ID | P00749 |
| Domains | KR, Tryp_SPc |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Protease |
| Protein Pathways | Complement and coagulation cascades |
| Gene Summary | This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] Transcript Variant: This variant (1) encodes the longest isoform (1). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Methyl-CpG-binding protein 2 mediates antifibrotic effects in scleroderma fibroblasts
,He, Y;Tsou, PS;Khanna, D;Sawalha, AH;,
Ann. Rheum. Dis.
,PubMed ID 29760157
[PLAU]
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Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC202083 | PLAU (Myc-DDK-tagged)-Human plasminogen activator, urokinase (PLAU), transcript variant 1 |
CNY 5,488.00 |
|
| RC202083L1 | Lenti ORF clone of Human plasminogen activator, urokinase (PLAU), transcript variant 1, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC202083L2 | Lenti ORF clone of Human plasminogen activator, urokinase (PLAU), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC202083L3 | Lenti ORF clone of Human plasminogen activator, urokinase (PLAU), transcript variant 1, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC202083L4 | Lenti ORF clone of Human plasminogen activator, urokinase (PLAU), transcript variant 1, mGFP tagged |
CNY 7,888.00 |
|
| RG202083 | PLAU (tGFP-tagged) - Human plasminogen activator, urokinase (PLAU), transcript variant 1 |
CNY 7,088.00 |
