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SH2D1A (NM_002351) Human Untagged Clone
CAT＃: SC118690
SH2D1A (untagged)-Human SH2 domain containing 1A (SH2D1A), transcript variant 1
CNY 1,200.00
CNY 2,950.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | DSHP; EBVS; IMD5; LYP; MTCP1; SAP; SAP/SH2D1A; XLP; XLPD; XLPD1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_002351 edited
ATGGACGCAGTGGCTGTGTATCATGGCAAAATCAGCAGGGAAACCGGCGAGAAGCTCCTG CTTGCCACTGGGCTGGATGGCAGCTATTTGCTGAGGGACAGCGAGAGCGTGCCAGGCGTG TACTGCCTATGTGTGCTGTATCACGGTTACATTTATACATACCGAGTGTCCCAGACAGAA ACAGGTTCTTGGAGTGCTGAGACAGCACCTGGGGTACATAAAAGATATTTCCGGAAAATA AAAAATCTCATTTCAGCATTTCAGAAGCCAGATCAAGGCATTGTAATACCTCTGCAGTAT CCAGTTGAGAAGAAGTCCTCAGCTAGAAGTACACAAGGTACTACAGGGATAAGAGAAGAT CCTGATGTCTGCCTGAAAGCCCCATGA >OriGene 5' read for NM_002351 unedited
GGTCAAAATTTGTAAACGACTCATATAGGGCGGCCGCGAATTCGCACGAGGGGAGTCAGG TGGTTGACTTGTGCCTGGCTGCAGTAGCAGCGGCATCTCCCTTGCACAGTTCTCCTCCTC GGCCTGCCCAAGAGTCCACCAGGCCATGGACGCAGTGGCTGTGTATCATGGCAAAATCAG CAGGGAAACCGGCGAGAAGCTCCTGCTTGCCACTGGGCTGGATGGCAGCTATTTGCTGAG GGACAGCGAGAGCGTGCCAGGCGTGTACTGCCTATGTGTGCTGTATCACGGTTACATTTA TACATACCGAGTGTCCCAGACAGAAACAGGTTCTTGGAGTGCTGAGACAGCACCTGGGGT ACATAAAAGATATTTCCGGAAAATAAAAAATCTCATTTCAGCATTTCAGAAGCCAGATCA AGGCATTGTAATACCTCTGCAGTATCCAGTTGAGAAGAAGTCCTCAGCTAGAAGTACACA AGGTACTACAGGGATAAGAGAAGATCCTGATGTCTGCCTGAAAGCCCCATGAAGAANAAT AAAACACCTTGTACTTTATTTTCTATAATTTAAATATATGCTAAGTCTTATATATTGTAG ATAATACAGTTCGGTGAGCTACAAATGCATTTCTAAAGCCATTGTAGTCCTGTAATGGAA GCATCTAGCATGTCGTCAAAGCTGANATGGACTTTTGTACATAGTGAGGAGCTTNTGAAC GAGGATTGGGAAAAAGNTATTCCCCGTAGTATTTTCAGTTATTATATTTACAAATGGGAA ACAAANGGATNATGAATACTTTATAAAGGATTAAATGTCATTTCTGNNCCAATATAATAA AAATATCCTCCATTTTTTGTGAAAAGCTTCATTTTTAGTGAAATATATTTTATAGCTACT AATTTTAAAANTGTCTGCNNTGATGATGGG >OriGene 3' read for NM_002351 unedited
NTTCTACTTGNACGCGGCCGCATTCTANGATCGAGTTTTTTTTTTTTTTTTTTAAAGCTT TCAAACACTTTATTTAAATGTGAAAGACTTGATGATTCAAAAAAAGCTTTTTTTCAAAAA AAGGCTCTTGGAAGTGAACATGCAAACATAATTCATATGTTTAGGATTATTCCAGAATGA ACACATTATAGAGTTAAAATTAGTTACGCCTATTACAATTTAAACTCAAGCCATATAATT AAAAATTATTAAACCTATGCAACTTATTATGAAAGTAGGATTTTTAAATTCCTTTACAAG TTCATGTGATGCTTTTACCTCAAGAAATGGTAAACCACCCATAATGCATTACTCAGGCCA CACTCCACTTTTGTACTCCCACGGCATCCATATTAAATGCTCAGAAATCAGGTCTTGCCA GTACATGGAGAATAGCTCTGTCTCTCAGCAGTTCACTAATTAAAACCAAGTTCACCAACA CCCATACACAATCCAGAATTCCCAGTTATTATTTTACAGTGAAGCTTAGCCTTTTCATAT GGCCCATGGACCAGAGTATTTGCACTGACCTATCTATCTGCCTCTAAAGACCAGATCTAC CTACACACGGGGAACCTCGCTTATCATGTACTTATCAACTTTCATTGGTATTTTTTCCTT GGCTTTTATTGGTATTNTCTTTCACTGGCTTTTATCGNTATTTTCTTTCACTGTCTTTTA TCGNTATTGTTTTCTCGTCCACAAGACAGTGAACTGAGAGCAGGGACCAGGTGTTTTTAC TTCTATGCCCTCAGCGCCCTATTATGTNTGNTGAGTGAATGAANTCTGTGAGCCCTGTNG CAAAGTGACATANTATCAATCACAAAATCACCAAAATATTAATGTGAGAAGAAAATGCCG CATAAAATCTGTATCTCGTGGTAGTTTCAATCACTTG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002351 |
| Insert Size | 2390 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002351.1, NP_002342.1 |
| RefSeq Size | 2530 bp |
| RefSeq ORF | 387 bp |
| Locus ID | 4068 |
| UniProt ID | O60880 |
| Domains | SH2 |
| Protein Families | Druggable Genome |
| Protein Pathways | Natural killer cell mediated cytotoxicity |
| Gene Summary | This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Identification of a novel nonsense mutation in SH2D1A in a patient with X-linked lymphoproliferative syndrome type 1: a case report
,Lyu, X;Guo, Z;Li, Y;Fan, R;Song, Y;,
BMC Med. Genet.
,PubMed ID 29649976
[SH2D1A]
|
|
Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production
,Karampetsou, MP;Comte, D;Kis-Toth, K;Terhorst, C;Kyttaris, VC;Tsokos, GC;,
J. Immunol.
,PubMed ID 27183584
[SH2D1A]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC204723 | SH2D1A (Myc-DDK-tagged)-Human SH2 domain containing 1A (SH2D1A), transcript variant 1 |
CNY 1,200.00 |
|
| RC204723L1 | Lenti ORF clone of Human SH2 domain containing 1A (SH2D1A), transcript variant 1, Myc-DDK-tagged |
CNY 3,600.00 |
|
| RC204723L2 | Lenti ORF clone of Human SH2 domain containing 1A (SH2D1A), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC204723L3 | Lenti ORF clone of Human SH2 domain containing 1A (SH2D1A), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC204723L4 | Lenti ORF clone of Human SH2 domain containing 1A (SH2D1A), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG204723 | SH2D1A (tGFP-tagged) - Human SH2 domain containing 1A (SH2D1A), transcript variant 1 |
CNY 2,800.00 |
