United States
Germany
Japan
United Kingdom
China
HLA DMB (HLA-DMB) (NM_002118) Human Untagged Clone
CAT＃: SC118844
HLA (untagged)-Human major histocompatibility complex, class II, DM beta (HLA-DMB)
CNY 2,400.00
CNY 2,950.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | D6S221E; RING7 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC118844 sequence for NM_002118 edited (data generated by NextGen Sequencing)
ATGATCACATTCCTGCCGCTGCTGCTGGGGCTCAGCCTGGGCTGCACAGGAGCAGGTGGC TTCGTGGCCCATGTGGAAAGCACCTGTCTGTTGGATGATGCTGGGACTCCAAAGGATTTC ACATACTGCATCTCCTTCAACAAGGATCTGCTGACCTGCTGGGATCCAGAGGAGAATAAG ATGGCCCCTTGCGAATTTGGGGTGCTGAATAGCTTGGCGAATGTCCTCTCACAGCACCTC AACCAAAAAGACACCCTGATGCAGCGCTTGCGCAATGGGCTTCAGAATTGTGCCACACAC ACCCAGCCCTTCTGGGGATCACTGACCAACAGGACACGGCCACCATCTGTGCAAGTAGCC AAAACCACTCCTTTTAACACGAGGGAGCCTGTGATGCTGGCCTGCTATGTGTGGGGCTTC TATCCAGCAGAAGTGACTATCACGTGGAGGAAGAACGGGAAGCTTGTCATGCCTCACAGC AGTGCGCACAAGACTGCCCAGCCCAATGGAGACTGGACATACCAGACCCTCTCCCATTTA GCCTTAACCCCCTCTTACGGGGACACTTACACCTGTGTGGTAGAGCACACTGGGGCTCCT GAGCCCATCCTTCGGGACTGGACACCTGGGCTGTCCCCCATGCAGACCCTGAAGGTTTCT GTGTCTGCAGTGACTCTGGGCCTGGGCCTCATCATCTTCTCTCTTGGTGTGATCAGCTGG CGGAGAGCTGGCCACTCTAGTTACACTCCTCTTCCTGGGTCCAATTATTCAGAAGGATGG CACATTTCCTAG Clone variation with respect to NM_002118.4 >OriGene 5' read for NM_002118 unedited
GGTTTGCGNATTTGTATACGACTCATATAGGGCGGCCGCGAATTCGCACGAGGCCCACAT CACTCATTTGGGGGGTCAAGGGACCCGGGCAATATAGTATTCTGCTCAGTGTCTGGAGAT CATCTACCCAGGCTGGGGCTTCTGGGACAGGCGAGGACCCACGGACCCTGGAAGAGCTGG TCCAGGGGACTGAACTCCCGGCATCTTTACAGAGCAGAGCATGATCACATTCCTGCCGCT GCTGCTGGGGCTCAGCCTGGGCTGCACAGGAGCAGGTGGCTTCGTGGCCCATGTGGAAAG CACCTGTCTGTTGGATGATGCTGGGACTCCAAAGGATTTCACATACTGCATCTCCTTCAA CAAGGATCTGCTGACCTGCTGGGATCCAGAGGAGAATAAGATGGCCCCTTGCGAATTTGG GGTGCTGAATAGCTTGGCGAATGTCCTCTCACAGCACCTCAACCAAAAAGACACCCTGAT GCAGCGCTTGCGCAATGGGCTTCAGAATTGTGCCACACACACCCAGCCCTTCTGGGGATC ACTGACCAACAGGACACGGCCACCATCTGTGCAAGTAGCCAAAACCACTCCTTTTAACAC GAGGGAGCCTGTGATGCTGGCCTGCTATGTGTGGGGCTTCTATCCAGCAGAAGTGACTAT CACGTGGAGGAAGAACGGGAAGCTTGTCATGCCTCACAGCAGTGCGCACAAGACTGCCCA GCCCAATGGAGACTGGACATACCAGACCCTCTCCCATTTAGCCTTAACCCCCTCTTACCG NGACACTTACACCTGTGTGGTAGAGCACACTGGGGCTTCTGAGCCATCCTTCGGNACTGG ACACCTGNGCTGTCCCCATGCAGACCCTGAAGTTTCTGTGTCTGCAGTGACT >OriGene 3' read for NM_002118 unedited
CCCGCAATCNAAAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTCCCACCAAAGTTTATTTTTTTGAAACAATCACCAGTTGTTGTCCT TTATGGCACACTGAAACCCCCAGGAGGGTTTTTAACTCCCTTCCTAAAATTATATTCATC CCAAAAATATACCCTTGGACAATATTTTGGTTACAGCATAACCCCAGAAAGGGGGGCCCC CAAGTTGCTAATTTTTACATAGGGGAAACTGGGAAATTAAAAAAATTGGATGGAAAAACC TTAGGATCCAAAATATTGTCGGGGGGTTAAAAATGTTGAAAAGGCATGGAACCATCATTG AGTTGAAATCTCCTTCTCACTTGGAGGGAAATTTGCAAAATTCTCCCTTTAGGAAAGGCG CCATCCTTCTGAATAATGGGCCCCAGAAAAAGGAGGGTAACTAAAGGGGCCAGTTTTCCC CCAGTTGATCCCCCCAAAAAAAAAAATGATGAGGCCCACGCCCAAAGTCACTGAAAACAC AAAAACCTTAAGGGTCTGATTGGGGGACACCCCAAGGGTCCACCCCCGAGGGTGGGCTAA GGACCCCCAGGGGCCCTACCACACGGGGTAATTTCCCCCTAAAGGGGGCCAACGCTATAT GGAAAGGGCCCGTCTCCCCAATTCTATTGGGCTGGCCAACCTTCCCCCCCCTGTCGGCAG GTCCCCAACTTCGCCGTGTTTCTCCCCGCCATCCCCCTTTGTTTGAAAAACGCGACATGG CCCGCACCTTTCCGGCCCCTCAGCTAAAAGAGGGCTTTTTTTTTTCTACATGTGGTAAAA CCACGCGCGAAAGACACCCCAAGGCCGCGCCCCGCCATCACCTCCGTCCTTTCTCCACTC CATATACCAAAAATTCTTCCCGCTTCGTGTTTCTGTCACCTTCCAG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002118 |
| Insert Size | 1470 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002118.3, NP_002109.1 |
| RefSeq Size | 1358 bp |
| RefSeq ORF | 792 bp |
| Locus ID | 3109 |
| UniProt ID | P28068 |
| Domains | MHC_II_beta, ig, IGc1 |
| Protein Families | Transmembrane |
| Protein Pathways | Allograft rejection, Antigen processing and presentation, Asthma, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Graft-versus-host disease, Systemic lupus erythematosus, Type I diabetes mellitus, Viral myocarditis |
| Gene Summary | HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC203811 | HLA (Myc-DDK-tagged)-Human major histocompatibility complex, class II, DM beta (HLA-DMB) |
CNY 2,400.00 |
|
| RC203811L3 | Lenti ORF clone of Human major histocompatibility complex, class II, DM beta (HLA-DMB), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC203811L4 | Lenti ORF clone of Human major histocompatibility complex, class II, DM beta (HLA-DMB), mGFP tagged |
CNY 5,890.00 |
|
| RG203811 | HLA (tGFP-tagged) - Human major histocompatibility complex, class II, DM beta (HLA-DMB) |
CNY 4,000.00 |
其它HLA DMB产品
