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Cathepsin D (CTSD) (NM_001909) Human Untagged Clone
CAT＃: SC118936
CTSD (untagged)-Human cathepsin D (CTSD)
CNY 3,656.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CLN10; CPSD; HEL-S-130P |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_001909 edited
GAATTCGGCACGAGGCCGGCTATAAGCGCACGGCCTCGGCGACCCTCTCCGACCCGGCCG CCGCCGCCATGCAGCCCTCCAGCCTTCTGCCGCTCGCCCTCTGCCTGCTGGCTGCACCCG CCTCCGCGCTCGTCAGGATCCCGCTGCACAAGTTCACGTCCATCCGCCGGACCATGTCGG AGGTTGGGGGCTCTGTGGAGGACCTGATTGCCAAAGGCCCCGTCTCAAAGTACTCCCAGG CGGTGCCAGCCGTGACCGAGGGGCCCATTCCCGAGGTGCTCAAGAACTACATGGACGCCC AGTACTACGGGGAGATTGGCATCGGGACGCCCCCCCAGTGCTTCACAGTCGTCTTCGACA CGGGCTCCTCCAACCTGTGGGTCCCCTCCATCCACTGCAAACTGCTGGACATCGCTTGCT GGATCCACCACAAGTACAACAGCGACAAGTCCAGCACCTACGTGAAGAATGGTACCTCGT TTGACATCCACTATGGCTCGGGCAGCCTCTCCGGGTACCTGAGCCAGGACACTGTGTCGG TGCCCTGCCAGTCAGCGTCGTCAGCCTCTGCCCTGGGCGGTGTCAAAGTGGAGAGGCAGG TCTTTGGGGAGGCCACCAAGCAGCCAGGCATCACCTTCATCGCAGCCAAGTTCGATGGCA TCCTGGGCATGGCCTACCCCCGCATCTCCGTCAACAACGTGCTGCCCGTCTTCGACAACC TGATGCAGCAGAAGCTGGTGGACCAGAACATCTTCTCCTTCTACCTGAGCAGGGACCCAG ATGCGCAGCCTGGGGGTGAGCTGATGCTGGGTGGCACAGACTCCAAGTATTACAAGGGTT CTCTGTCCTACCTGAATGTCACCCGCAAGGCCTACTGGCAGGTCCACCTGGACCAGGTGG AGGTGGCCAGCGGGCTGACCCTGTGCAAGGAGGGCTGTGAGGCCATTGTGGACACAGGCA CTTCCCTCATGGTGGGCCCGGTGGATGAGGTGCGCGAGCTGCAGAAGGCCATCGGGGCCG TGCCGCTGATTCAGGGCGAGTACATGATCCCCTGTGAGAAGGTGTCCACCCTGCCCGCGA TCACACTGAAGCTGGGAGGCAAAGGCTACAAGCTGTCCCCAGAGGACTACACGCTCAAGG TGTCGCAGGCCGGGAAGACCCTCTGCCTGAGCGGCTTCATGGGCATGGACATCCCGCCAC CCAGCGGGCCACTCTGGATCCTGGGCGACGTCTTCATCGGCCGCTACTACACTGTGTTTG ACCGTGACAACAACAGGGTGGGCTTCGCCGAGGCTGCCCGCCTCTAGTTCCCAAGGCGTC CGCGCGCCAGCACAGAAACAGAGGAGAGTCCCAGAGCAGGAGGCCCCTGGCCCAGCGGCC CCTCCCACACACACCCACACACTCGCCCGCCCACTGTCCTGGGCGCCCTGGAAGCCGGCG GCCCAAGCCCGACTTGCTGTTTTGTTCTGTGGTTTTCCCCTCCCTGGGTTCAGAAATGCT GCCTGCCTGTCTGTCTCTCCATCTGTTTGGTGGGGGTAGAGCTGATCCAGAGCACAGATC TGTTTCGTGCATTGGAAGACCCCACCCAAGCTTGGCAGCCGAGCTCGTGTATCCTGGGGC TCCCTTCATCTCCAGGGAGTCCCCTCCCCGGCCCTACCAGCGCCCGCTGGGCTGAGCCCC TACCCCACACCAGGCCGTCCTCCCGGGCCCTCCCTTGGAAACCTGCCCTGCCTGAGGGCC CCTCTGCCCAGCTTGGGCCCAGCTGGGCTCTGCCACCCTACCTGTTCAGTGTCCCGGGCC CGTTGAGGATGAGGCCGCTAGAGGCCTGAGGATGAGCTGGAAGGAGTGAGAGGGGACAAA ACCCACCTTGTTGGAGCCTGCAGGGTGGTGCTGGGACTGAGCCAGTCCCAGGGGCATGTA TTGGCCTGGAGGTGGGGTTGGGATTGGGGGCTGGTGCCAGCCTTCCTCTGCAGCTGACCT CTGTTGTCCTCCCCTTGGGCGGCTGAGAGCCCCAGCTGACATGGAAATACAGTTGTTGGC CTCCGGCCTCCCCTCAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_001909 unedited
NGGTTCAAATTTGTATACGACTCCTATAGGCGGCCCGCGAATTCGCACGAGGCCGGCTAT AAGCGCACGGCCTCGGCGACCCTCTCCGACCCGGCCGCCGCCGCCATGCAGCCCTCCAGC CTTCTGCCGCTCGCCCTCTGCCTGCTGGCTGCACCCGCCTCCGCGCTCGTCAGGATCCCG CTGCACAAGTTCACGTCCATCCGCCGGACCATGTCGGAGGTTGGGGGCTCTGTGGAGGAC CTGATTGCCAAAGGCCCCGTCTCAAAGTACTCCCAGGCGGTGCCAGCCGTGACCGAGGGG CCCATTCCCGAGGTGCTCAAGAACTACATGGACGCCCAGTACTACGGGGAGATTGGCATC GGGACGCCCCCCCAGTGCTTCACAGTCGTCTTCGACACGGGCTCCTCCAACCTGTGGGTC CCCTCCATCCACTGCAAACTGCTGGACATCGCTTGCTGGATCCACCACAAGTACAACAGC GACAAGTCCAGCACCTACGTGAAGAATGGTACCTCGTTTGACATCCACTATGGCTCGGGC AGCCTCTCCGGGTACCTGAGCCAGGACACTGTGTCGGTGCCCTGCCAGTCAGCGTCGTCA GCCTCTGCCCTGNGCGGTGTCAAAGTGGAGAGGCAGGTCTTTGGGGAGGCCACCAAGCAG CCAGGCATCACCTTCATCGCAGCCAAGTTCGATGGCATCCTGGGCATGGCCTACCCCCGC ATCTCCGTCAACAACGTGCTGCCCGTCTTCGACAACCTGATGCAGCAGAAGCTGGTGGAC CAGAACATCTTCTCCTTCTACCTGAGCAGGNACCCAGATGCGCAGCCTGGNGGGTGAGCT GATGCCTGGTGGCACAGACTCCAAGATTACAGGGTTTCTCTGTCTACCTGAATGTCACCC CGCAGGCTACTGGC >OriGene 3' read for NM_001909 unedited
ACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGAGGGGAGGCCGNGAGC CAACAACTGTATTTCCATGTCAGCTGGGGCTCTCAGCCGCCCAAGGGGAGGACAACAGAG GTCAGCTGCAGAGGAAGGCTGGCACCAGCCCCCAATCCCAACCCCACCTCCAGGCCAATA CATGCCCCTGGGACTGGCTCAGTCCCAGCACCACCCTGCAGGCTCCAACAAGGTGGGTTT TGTCCCCTCTCACTCCTTCCAGCTCATCCTCAGGCCTCTAGCGGCCTCATCCTCAACGGG CCCGGGACACTGAACAGGTAGGGTGGCAGAGCCCAGCTGGGCCCAAGCTGGGCAGAGGGG CCCTCAGGCAGGGCAGGTTTCCAAGGGAGGGCCCGGGAGGACGGCCTGGTGTGGGGTAGG GGCTCAGCCCAGCGGGCGCTGGTAGGGCCGGGGAGGGGACTCCCTGGAGATGAAGGGAGC CCCAGGATACACGAGCTCGGCTGCCAAGCTTGGGTGGGGTCTTCCAATGCACGAAACAGA TCTGTGCTCTGGATCAGCTCTACCCCCACCAAACAGATGGAGAGACAGACAGGCAGGCAG CATTTCTGAACCCAGGGAGGGGAAAACCACAGAACANAACAGCAAGTCGGGCTTGGGCCG CCGGCTTCCAGGGCGCCCANNACAGTGGGCGGGCAANTGTGTGGGTGTGTGTGGGAGGGG CCCCCTGGCCAGGGGCCTCCTGCTCTGGGACTCTNCTCTGTTTCTGTGCTGGCGCGCGGA CGCCTTGGGACTAGAGGGCGGCANCTCCGCGAAGCCCACCTGTTGGTGTACGGGTCAACA CGTGTATTAGCGGCGATGAAAACCTCCCCCAGATCCAAATGGCCCCCGGGTTGCGGGATG TCATGCCATGAACCGCTCAGCAAAGGTCTTCCCN |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001909 |
| Insert Size | 2190 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001909.3, NP_001900.1 |
| RefSeq Size | 2205 bp |
| RefSeq ORF | 1239 bp |
| Locus ID | 1509 |
| UniProt ID | P07339 |
| Domains | asp |
| Protein Families | Druggable Genome, Protease |
| Protein Pathways | Lysosome |
| Gene Summary | This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Hyperglycemia-induced cardiomyocyte death is mediated by lysosomal membrane injury and aberrant expression of cathepsin D
,Kobayashi, S;Zhao, F;Kobayashi, T;Hagiwara, M;Kaminaris, A;Li, C;Cai, F;Huang, Y;Liang, Q;,
Biochem. Biophys. Res. Commun.
,PubMed ID 31862139
[CTSD]
|
|
Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
,Valerie Cullen,Maria Lindfors, Juliana Ng, Anders Paetau, Erika Swinton, Piotr Kolodziej, Heather Boston, Paul Saftig, John Woulfe, Mel B Feany, Liisa Myllykangas, Michael G Schlossmacher and Jaana Tyynelä,
Molecular Brain 2009, 2:5
[CTSD]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC200719 | CTSD (Myc-DDK-tagged)-Human cathepsin D (CTSD) |
CNY 5,488.00 |
|
| RC200719L1 | Lenti ORF clone of Human cathepsin D (CTSD), Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC200719L2 | Lenti ORF clone of Human cathepsin D (CTSD), mGFP tagged |
CNY 7,888.00 |
|
| RC200719L3 | Lenti ORF clone of Human cathepsin D (CTSD), Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC200719L4 | Lenti ORF clone of Human cathepsin D (CTSD), mGFP tagged |
CNY 7,888.00 |
|
| RG200719 | CTSD (tGFP-tagged) - Human cathepsin D (CTSD) |
CNY 7,088.00 |
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