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GRK2 (NM_001619) Human Untagged Clone
CAT＃: SC119158
ADRBK1 (untagged)-Human adrenergic, beta, receptor kinase 1 (ADRBK1)
CNY 5,056.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ADRBK1; BARK1; BETA-ARK1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_001619 edited
ATGGCGGACCTGGAGGCGGTGCTGGCCGACGTGAGCTACCTGATGGCCATGGAGAAGAGC AAGGCCACGCCGGCCGCGCGCGCCAGCAAGAAGATACTGCTGCCCGAGCCCAGCATCCGC AGTGTCATGCAGAAGTACCTGGAGGACCGGGGCGAGGTGACCTTTGAGAAGATCTTTTCC CAGAAGCTGGGGTACCTGCTCTTCCGAGACTTCTGCCTGAACCACCTGGAGGAGGCCAGG CCCTTGGTGGAATTCTATGAGGAGATCAAGAAGTACGAGAAGCTGGAGACGGAGGAGGAG CGTGTGGCCCGCAGCCGGGAGATCTTCGACTCATACATCATGAAGGAGCTGCTGGCCTGC TCGCATCCCTTCTCGAAGAGTGCCACTGAGCATGTCCAAGGCCACCTGGGGAAGAAGCAG GTGCCTCCGGATCTCTTCCAGCCATACATCGAAGAGATTTGTCAAAACCTCCGAGGGGAC GTGTTCCAGAAATTCATTGAGAGCGATAAGTTCACACGGTTTTGCCAGTGGAAGAATGTG GAGCTCAACATCCACCTGACCATGAATGACTTCAGCGTGCATCGCATCATTGGGCGCGGG GGCTTTGGCGAGGTCTATGGGTGCCGGAAGGCTGACACAGGCAAGATGTACGCCATGAAG TGCCTGGACAAAAAGCGCATCAAGATGAAGCAGGGGGAGACCCTGGCCCTGAACGAGCGC ATCATGCTCTCGCTCGTCAGCACTGGGGACTGCCCATTCATTGTCTGCATGTCATACGCG TTCCACACGCCAGACAAGCTCAGCTTCATCCTGGACCTCATGAACGGTGGGGACCTGCAC TACCACCTCTCCCAGCACGGGGTCTTCTCAGAGGCTGACATGCGCTTCTATGCGGCCGAG ATCATCCTGGGCCTGGAGCACATGCACAACCGCTTCGTGGTCTACCGGGACCTGAAGCCA GCCAACATCCTTCTGGACGAGCATGGCCACGTGCGGATCTCGGACCTGGGCCTGGCCTGT GACTTCTCCAAGAAGAAGCCCCATGCCAGCGTGGGCACCCACGGGTACATGGCTCCGGAG GTCCTGCAGAAGGGCGTGGCCTACGACAGCAGTGCCGACTGGTTCTCTCTGGGGTGCATG CTCTTCAAGTTGCTGCGGGGGCACAGCCCCTTCCGGCAGCACAAGACCAAAGACAAGCAT GAGATCGACCGCATGACGCTGACGATGGCCGTGGAGCTGCCCGACTCCTTCTCCCCTGAA CTACGCTCCCTGCTGGAGGGGTTGCTGCAGAGGGATGTCAACCGGAGATTGGGCTGCCTG GGCCGAGGGGCTCAGGAGGTGAAAGAGAGCCCCTTTTTCCGCTCCCTGGACTGGCAGATG GTCTTCTTGCAGAAGTACCCTCCCCCGCTGATCCCCCCACGAGGGGAGGTGAACGCGGCC GACGCCTTCGACATTGGCTCCTTCGATGAGGAGGACACAAAAGGAATCAAGTTACTGGAC AGTGATCAGGAGCTCTACCGCAACTTCCCCCTCACCATCTCGGAGCGGTGGCAGCAGGAG GTGGCAGAGACTGTCTTCGACACCATCAACGCTGAGACAGACCGGCTGGAGGCTCGCAAG AAAGCCAAGAACAAGCAGCTGGGCCATGAGGAAGACTACGCCCTGGGCAAGGACTGCATC ATGCATGGCTACATGTCCAAGATGGGCAACCCCTTCCTGACCCAGTGGCAGCGGCGGTAC TTCTACCTGTTCCCCAACCGCCTCGAGTGGCGGGGCGAGGGCGAGGCCCCGCAGAGCCTG CTGACCATGGAGGAGATCCAGTCGGTGGAGGAGACGCAGATCAAGGAGCGCAAGTGCCTG CTCCTCAAGATCCGCGGTGGGAAACAGTTCATTTTGCAGTGCGATAGCGACCCTGAGCTG GTGCAGTGGAAGAAGGAGCTGCGCGACGCCTACCGCGAGGCCCAGCAGCTGGTGCAGCGG GTGCCCAAGATGAAGAACAAGCCGCGCTCGCCCGTGGTGGAGCTGAGCAAGGTGCCGCTG GTCCAGCGCGGCAGTGCCAACGGCCTCTGA >OriGene 5' read for NM_001619 unedited
CTATAGGGGCGGCCGCGAATTCGCACGAGGCGGGGCCGGAGGCGGCGGCGGCTCCGGGGC GCGGGCGCGCGGGCGGCGGCGGCGGCGGCGCCCCGACTGCAGTCCCGGCGGGAGCGGAGC GCGAGCCGGGGCCGGGCCCGAGCCGGCGCCATGGGGCGGCGCCGCCTGTGAGCGGCGGCG AGCGGAGCCGCGGGCGCCGAGCAGGGCCAGGCGGGAGGCGTCGGCGCCCGAGGCCGAGCG AGCCGCGGCCGGGCCGGGCCGAGCGCCGAGCGAGCAGGAGCGGCGGCGGCGGCGGCGGCG GCGGGAGGAGGCAGCGCCGCCGCCAAGATGGCGGACCTGGAGGCGGTGCTGGCCGACGTG AGCTACCTGATGGCCATGGAGAAGAGCAAGGCCACGCCGGCCGCGCGCGCCAGCAAGAAG ATACTGCTGCCCGAGCCCAGCATCCGCAGTGTCATGCAGAAGTACCTGGAGGACCGGGGC GAGGTGACCTTTGAGAAGATCTTTTCCCAGAAGCTGGGGTACCTGCTCTTCCGAGACTTC TGCCTGAACCACCTGGAGGAGGCCANGCCCTTGGTGNGATTCTATGAGGAGATCAAGAAG TACCAAAAGCTGGAGACGGAGGAAGAGCGTGTGGCCCGCACCCGGAGATCTTCGACTCAT ACATCATGAAAGAGCTGCTGGCCTGCTCGCATCCCTTCTCGAGAGTGCCACTGAGCATGT CCACAGCCACCTGGGGGAGAAGCAGGTGCCTCCGGATTTTTTCAGCCTACATTGAAAAGA TTTGCCAAACCTCCGAGGGGACGGGTTCCGAACTTCATGGGAACAAAAGTTCCCCCGTTT TGCCGTGGAATAATGTGGAGCTCCACATCCCTGACCTGAATACTTAACGGCATCCATTAT TGGGCGGGGGCTTTGCGAGGCTTATGGGCCGGAGGTTCACACGCAATGTCCCCTGTAGCC TGACAAACGCTTAAATGAACGGGGGACCCTGGCTGAAACGATTGTTCTTTTCACCTGGAT CCTAT >OriGene 3' read for NM_001619 unedited
GGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTACTCTTTAAAACACATTCAAAA ATCGGCAAAGAAACGCCCCGGGGAATGAGTAGACGGGAGGGGAGGGTGCGCCAACCCAGC CCCGGGGGGGAGAAGGCGCGACACCACACAGGCAGCGCGACTGGCACGAGGGGGCATGCG GTGGGCGAGGCGGCGGCACTGACAGGACGTGGGCTGTGGGGCTGGCCAGCCTGGGCGGGG GTACACTGATGGGCCAGGATGGGGGGCACACTGATAGGCCCCAGCCAGCCTCCTTGCTGT GCTGCCCGCCCACCTGGCCGGCCCCGTCCTGGGCAGATGGGGTCGCACCCAGCCCAGCAT CAGCGAGACCTCAGGCCAGGCGAGGCCAGTATGGCCCAACCTGCAGGTGCCTTGCTGTGG TCCCTGAGCCCGGGTGCTGGGGGTTGGGGCAAGAGGGGACAGCAGGGAGGGTAGCAGCAC CTGCTGCCAATGCCACTCTCTCAGCCAAGCCCCGCAGTGTCAGGGAAGTGGGAGTGGAGG CAGCCAGTGACACAGAGGCTTTTCCCTGATAAGGGCACAGGAGCCCGAGTCACTGTGGGA GGCCTTGAGGGCCAGGGAGACAACGGGCCCCTCCTCTCGCCAACACTGTGGAGCAGGACA GTGCAAGGCCTGCCCCTCTGCACCAGGACGGGGCGCAGTTGGGAAAATCCAAGCCGGATC CCTGGGCTTGTGCCCTGCCCTTGGGGAAGGGGGGCCGGGCCCCCCNCTCACGCCCCCATT GGCACCCATCCGTATCCCCTTTCACACCCCTGTGGACACCACCTCGTTGTGCCACCCACA CACTGCACAACCGTATATCCCTCCACACCCACCCTTCTCCGCCCCCGTCATCCCAACGTC ACCCGGTACCGCCACATTCACCCCGCACTACATTGCTCGCCCCCGTGTACCCCCGTCAAC GCAGATTACCGCCGTCCCCACCTTACTTGACGCGTTCGACACCCCAATCCACCTCGCCTG AATACCACACTTA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001619 |
| Insert Size | 2070 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001619.2, NP_001610.1 |
| RefSeq Size | 3603 bp |
| RefSeq ORF | 2070 bp |
| Locus ID | 156 |
| UniProt ID | P25098 |
| Domains | RGS, pkinase, S_TK_X, TyrKc, PH, S_TKc |
| Protein Families | Druggable Genome, Protein Kinase |
| Protein Pathways | Chemokine signaling pathway, Endocytosis |
| Gene Summary | This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and β-arrestin 2 in inflammatory macrophages
,Serafin, DS;Allyn, B;Sassano, MF;Timoshchenko, RG;Mattox, D;Brozowski, JM;Siderovski, DP;Truong, YK;Esserman, D;Tarrant, TK;Billard, MJ;,
Mol. Immunol.
,PubMed ID 30576947
[GRK2]
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Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC210327 | ADRBK1 (Myc-DDK-tagged)-Human adrenergic, beta, receptor kinase 1 (ADRBK1) |
CNY 5,072.00 |
|
| RC210327L1 | Lenti ORF clone of Human adrenergic, beta, receptor kinase 1 (ADRBK1), Myc-DDK-tagged |
CNY 7,472.00 |
|
| RC210327L2 | Lenti ORF clone of Human adrenergic, beta, receptor kinase 1 (ADRBK1), mGFP tagged |
CNY 7,700.00 |
|
| RC210327L3 | Lenti ORF clone of Human adrenergic, beta, receptor kinase 1 (ADRBK1), Myc-DDK-tagged |
CNY 7,700.00 |
|
| RC210327L4 | Lenti ORF clone of Human adrenergic, beta, receptor kinase 1 (ADRBK1), mGFP tagged |
CNY 7,472.00 |
|
| RG210327 | ADRBK1 (tGFP-tagged) - Human adrenergic, beta, receptor kinase 1 (ADRBK1) |
CNY 6,672.00 |
