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P Glycoprotein (ABCB1) (NM_000927) Human Untagged Clone
CAT＃: SC119584
ABCB1 (untagged)-Human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1)
CNY 13,376.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ABC20; CD243; CLCS; GP170; MDR1; p-170; P-GP; PGY1 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_000927 edited
CAAGCTCAAAGAAGCAGAGGCCGCTGTTCGTTTCCTTTAGGTCTTTCCACTAAAGTCGGA GTATCTTCTTCCAAAATTTCACGTCTTGGTGGCCGTTCCAAGGAGCGCGAGGTCGGGATG GATCTTGAAGGGGACCGCAATGGAGGAGCAAAGAAGAAGAACTTTTTTAAACTGAACAAT AAAAGTGAAAAAGATAAGAAGGAAAAGAAACCAACTGTCAGTGTATTTTCAATGTTTCGC TATTCAAATTGGCTTGACAAGTTGTATATGGTGGTGGGAACTTTGGCTGCCATCATCCAT GGGGCTGGACTTCCTCTCATGATGCTGGTGTTTGGAGAAATGACAGATATCTTTGCAAAT GCAGGAAATTTAGAAGATCTGATGTCAAACATCACTAATAGAAGTGATATCAATGATACA GGGTTCTTCATGAATCTGGAGGAAGACATGACCAGGTATGCCTATTATTACAGTGGAATT GGTGCTGGGGTGCTGGTTGCTGCTTACATTCAGGTTTCATTTTGGTGCCTGGCAGCTGGA AGACAAATACACAAAATTAGAAAACAGTTTTTTCATGCTATAATGCGACAGGAGATAGGC TGGTTTGATGTGCACGATGTTGGGGAGCTTAACACCCGACTTACAGATGATGTCTCCAAG ATTAATGAAGGAATTGGTGACAAAATTGGAATGTTCTTTCAGTCAATGGCAACATTTTTC ACTGGGTTTATAGTAGGATTTACACGTGGTTGGAAGCTAACCCTTGTGATTTTGGCCATC AGTCCTGTTCTTGGACTGTCAGCTGCTGTCTGGGCAAAGATACTATCTTCATTTACTGAT AAAGAACTCTTAGCGTATGCAAAAGCTGGAGCAGTAGCTGAAGAGGTCTTGGCAGCAATT AGAACTGTGATTGCATTTGGAGGACAAAAGAAAGAACTTGAAAGGTACAACAAAAATTTA GAAGAAGCTAAAAGAATTGGGATAAAGAAAGCTATTACAGCCAATATTTCTATAGGTGCT GCTTTCCTGCTGATCTATGCATCTTATGCTCTGGCCTTCTGGTATGGGACCACCTTGGTC CTCTCAGGGGAATATTCTATTGGACAAGTACTCACTGTATTCTTTTCTGTATTAATTGGG GCTTTTAGTGTTGGACAGGCATCTCCAAGCATTGAAGCATTTGCAAATGCAAGAGGAGCA GCTTATGAAATCTTCAAGATAATTGATAATAAGCCAAGTATTGACAGCTATTCGAAGAGT GGGCACAAACCAGATAATATTAAGGGAAATTTGGAATTCAGAAATGTTCACTTCAGTTAC CCATCTCGAAAAGAAGTTAAGATCTTGAAGGGTCTGAACCTGAAGGTGCAGAGTGGGCAG ACGGTGGCCCTGGTTGGAAACAGTGGCTGTGGGAAGAGCACAACAGTCCAGCTGATGCAG AGGCTCTATGACCCCACAGAGGGGATGGTCAGTGTTGATGGACAGGATATTAGGACCATA AATGTAAGGTTTCTACGGGAAATCATTGGTGTGGTGAGTCAGGAACCTGTATTGTTTGCC ACCACGATAGCTGAAAACATTCGCTATGGCCGTGAAAATGTCACCATGGATGAGATTGAG AAAGCTGTCAAGGAAGCCAATGCCTATGACTTTATCATGAAACTGCCTCATAAATTTGAC ACCCTGGTTGGAGAGAGAGGGGCCCAGTTGAGTGGTGGGCAGAAGCAGAGGATCGCCATT GCACGTGCCCTGGTTCGCAACCCCAAGATCCTCCTGCTGGATGAGGCCACGTCAGCCTTG GACACAGAAAGCGAAGCAGTGGTTCAGGTGGCTCTGGATAAGGCCAGAAAAGGTCGGACC ACCATTGTGATAGCTCATCGTTTGTCTACAGTTCGTAATGCTGACGTCATCGCTGGTTTC GATGATGGAGTCATTGTGGAGAAAGGAAATCATGATGAACTCATGAAAGAGAAAGGCATT TACTTCAAACTTGTCACAATGCAGACAGCAGGAAATGAAGTTGAATTAGAAAATGCAGCT GATGAATCCAAAAGTGAAATTGATGCCTTGGAAATGTCTTCAAATGATTCAAGATCCAGT CTAATAAGAAAAAGATCAACTCGTAGGAGTGTCCGTGGATCACAAGCCCAAGACAGAAAG CTTAGTACCAAAGAGGCTCTGGATGAAAGTATACCTCCAGTTTCCTTTTGGAGGATTATG AAGCTAAATTTAACTGAATGGCCTTATTTTGTTGTTGGTGTATTTTGTGCCATTATAAAT GGAGGCCTGCAACCAGCATTTGCAATAATATTTTCAAAGATTATAGGGGTTTTTACAAGA ATTGATGATCCTGAAACAAAACGACAGAATAGTAACTTGTTTTCACTATTGTTTCTAGCC CTTGGAATTATTTCTTTTATTACATTTTTCCTTCAGGGTTTCACATTTGGCAAAGCTGGA GAGATCCTCACCAAGCGGCTCCGATACATGGTTTTCCGATCCATGCTCAGACAGGATGTG AGTTGGTTTGATGACCCTAAAAACACCACTGGAGCATTGACTACCAGGCTCGCCAATGAT GCTGCTCAAGTTAAAGGGGCTATAGGTTCCAGGCTTGCTGTAATTACCCAGAATATAGCA AATCTTGGGACAGGAATAATTATATCCTTCATCTATGGTTGGCAACTAACACTGTTACTC TTAGCAATTGTACCCATCATTGCAATAGCAGGAGTTGTTGAAATGAAAATGTTGTCTGGA CAAGCACTGAAAGATAAGAAAGAACTAGAAGGTTCTGGGAAGATCGCTACTGAAGCAATA GAAAACTTCCGAACCGTTGTTTCTTTGACTCAGGAGCAGAAGTTTGAACATATGTATGCT CAGAGTTTGCAGGTACCATACAGAAACTCTTTGAGGAAAGCACACATCTTTGGAATTACA TTTTCCTTCACCCAGGCAATGATGTATTTTTCCTATGCTGGATGTTTCCGGTTTGGAGCC TACTTGGTGGCACATAAACTCATGAGCTTTGAGGATGTTCTGTTAGTATTTTCAGCTGTT GTCTTTGGTGCCATGGCCGTGGGGCAAGTCAGTTCATTTGCTCCTGACTATGCCAAAGCC AAAATATCAGCAGCCCACATCATCATGATCATTGAAAAAACCCCTTTGATTGACAGCTAC AGCACGGAAGGCCTAATGCCGAACACATTGGAAGGAAATGTCACATTTGGTGAAGTTGTA TTCAACTATCCCACCCGACCGGACATCCCAGTGCTTCAGGGACTGAGCCTGGAGGTGAAG AAGGGCCAGACGCTGGCTCTGGTGGGCAGCAGTGGCTGTGGGAAGAGCACAGTGGTCCAG CTCCTGGAGCGGTTCTACGACCCCTTGGCAGGGAAAGTGCTGCTTGATGGCAAAGAAATA AAGCGACTGAATGTTCAGTGGCTCCGAGCACACCTGGGCATCGTGTCCCAGGAGCCCATC CTGTTTGACTGCAGCATTGCTGAGAACATTGCCTATGGAGACAACAGCCGGGTGGTGTCA CAGGAAGAGATTGTGAGGGCAGCAAAGGAGGCCAACATACATGCCTTCATCGAGTCACTG CCTAATAAATATAGCACTAAAGTAGGAGACAAAGGAACTCAGCTCTCTGGTGGCCAGAAA CAACGCATTGCCATAGCTCGTGCCCTTGTTAGACAGCCTCATATTTTGCTTTTGGATGAA GCCACGTCAGCTCTGGATACAGAAAGTGAAAAGGTTGTCCAAGAAGCCCTGGACAAAGCC AGAGAAGGCCGCACCTGCATTGTGATTGCTCACCGCCTGTCCACCATCCAGAATGCAGAC TTAATAGTGGTGTTTCAGAATGGCAGAGTCAAGGAGCATGGCACGCATCAGCAGCTGCTG GCACAGAAAGGCATCTATTTTTCAATGGTCAGTGTCCAGGCTGGAACAAAGCGCCAGTGA ACTCTGACTGTATGAGATGTTAAATACTTTTTAATATTTGTTTAGATATGACATTTATTC AAAGTTAAAAGCAAACACTTACAGAATTATGAAGAGGTATCTGTTTAACATTTCCTCAGT CAAGTTCAGAGTCTTCAGAGACTTCGTAATTAAAGGAACAGAGTGAGAGACATCATCAAG TGGAGAGAAATCATAGTTTAAACTGCATTATAAATTTTATAACAGAATTAAAGTAGATTT TAAAAGATAAAATGTGTAATTTTGTTTATATTTTCCCATTTGGACTGTAACTGACTGCCT TGCTAAAAGATTATAGAAGTAGCAAAAAGTATTGAAATGTTTGCATAAAGTGTCTATAAT AAAACTAAACTTTCATGTGACTGGAGTCATCTTGTCCAAACTGCCTGTGAATATATCTTC TCTCAATTGGAATATTGTAGATAACTTCTGCTTTAAAAAAGTTTTCTTTAAATATACCTA CTCATTTTTGTGGGAATGGTTAAGCAGTTTAAATAATTCCTGTTGTATATGTCTATTCAC ATTGGGTCTTACAGAACCATCTGGCTTCATTCTTCTTGGACTTGATCCTGCTGATTCTTG CATTTCCACATTAAGGTGGCTCTCAAACCCAAAACACAGATCGATATAAGATTTTAGGAG GTGGGGTGAGGCACAATTATGAAGTGCATATTATTCAGATGTATAGTAAATACTTTGCAT TGCTTTTATAAAGGGTTCTTTAAGGATTTTTTAAGATTTTTACACTTCCAAAGTACATTT ACTTTTTGTCTTGATAATGAATCACTTTTGCCAGTAATTGGCCTCTTCCAAAAGTGATCC TTCTGACTTACAGATGTTTAAAATGTGCCATGAGTTTAACTACATCTTGATACAAACATG ATAAAAAAAAAAAAAAAAAA >OriGene 5' read for NM_000927 unedited
AGAAACTAGCGATTTTGTNAATACGNACTTCACTATAGGGNNCGGCCGCGCAATTCGGCA CGAGGCAAGCTCAAAGAAGCAGAGGCCGCTGTTCGTTTCCTTTAGGTCTTTCCACTAAAG TCGGAGTATCTTCTTCCAAAATTTCACGTCTTGGTGGCCGTTCCAAGGAGCGCGAGGTCG GGATGGATCTTGAAGGGGACCGCAATGGAGGAGCAAAGAAGAAGAACTTTTTTAAACTGA ACAATAAAAGTGAAAAAGATAAGAAGGAAAAGAAACCAACTGTCAGTGTATTTTCAATGT TTCGCTATTCAAATTGGCTTGACAAGTTGTATATGGTGGTGGGAACTTTGGCTGCCATCA TCCATGGGGCTGGACTTCCTCTCATGATGCTGGTGTTTGGAGAAATGACAGATATCTTTG CAAATGCAGGAAATTTAGAAGATCTGATGTCAAACATCACTAATAGAAGTGATATCAATG ATACAGGGTTCTTCATGAATCTGGAGGAAGACATGACCAGGTATGCCTATTATTACAGTG GAATTGGTGCTGGGGTGCTGGTTGCTGCTTACATTCAGGTTTCATTTTGGTGCCTGGCAG CTGGAAGACAAATACACAAAATTAGAAAACAGTTTTTTCATGCTATAATGCGACAGGAGA TAGGCTGGTTTGATGTGCACGATGTTGGGGAGCTTAACACCCGACTTACAGATGATGTCT CCAAGATTAATGAAGNGAATTGGGTGACAAATTGGAATGTTNCTTTCAGTCAATGGCAAC ATTTTTCACTGGGTTTATAGTAGGATTTACACGTGGTTTGAAGCTACCCCTTGTGATTTT GGCCATCAGTCCCTGTCTTGGACTGTCAACTGCTGTCTGGGCAAAGATCTATCTTCACTT ACTGATAAAGAACTCTTAGC >OriGene 3' read for NM_000927 unedited
AATGGAACCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTATCATGTTTGT ATCAAGATGTAGTTAAACTCATGGCACATTTTAAACATCTGTAAGTCAGAAGGATCACTT TTGGAAGAGGCCAATTACTGGCAAAAGTGATTCATTATCAAGACAAAAAGTAAATGTACT TTGGAAGTGTAAAAATCTTAAAAAATCCTTAAAGAACCCTTTATAAAAGCAATGCAAAGT ATTTACTATACATCTGAATAATATGCACTTCATAATTGTGCCTCACCCCACCTCCTAAAA TCTTATATCGATCTGTGTTTTGGGTTTGAGAGCCACCTTAATGTGGAAATGCAAGAATCA GCAGGATCAAGTCCAAGAAGAATGAAGCCAGATGGTTCTGTAAGACCCAATGTGAATAGA CATATACAACAGGAATTATTTAAACTGCTTAACCATTCCCACAAAAATGAGTAGGTATAT TTAAAGAAAACTTTTTTAAAGCAGAAGTTATCTACAATATTCCAATTGAGAGAAGATATA TTCACAGGCAGTTTGGACAAGATGACTCCAGTCACATGAAAGTTTAGTTTTATTATAGAC ACTTTATGCAAACATTTCAATACTTTTTGCTACTTCTATAATCTTTTAGCAAGGCAGTCA GTTACAGTCCAAATGGGAAAATATAAACAAAATTACACATTTTATCTTTTAAAATCTACT TTAATTCTGTTATAAAATTTATAATGCAGTTTAAACTATGATTTCTCTCCACTTGATGAT GTCTCTCACTCTGTTCCCTTAATTACGAAGTCTCTGAAGACTCTGAACTTGACTGAGGAA TGTTAAACAGAACCTCCTCATAATCTGAAGTGTTTGCTTTTAACTTTGATAAATGTCTAT CTAACCAAATTAAAAGTATTTACATCTATACAGTCGGAGTCACTGGCGCTTTGTTCCACC TGGCACTGACCATTGAAAAAATGCCTTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000927 |
| Insert Size | 4900 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone has been fully sequenced and the ORF associated with this clone was found to be a perfect match to NM_000927. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000927.3, NP_000918.2 |
| RefSeq Size | 4872 bp |
| RefSeq ORF | 3843 bp |
| Locus ID | 5243 |
| UniProt ID | P08183 |
| Domains | ABC_membrane, ABC_tran, AAA |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | ABC transporters |
| Gene Summary | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017] Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1. Variants 2, 3, and 4 all encode the same isoform (2). |
Documents
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| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC216080 | ABCB1 (Myc-DDK-tagged)-Human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) |
CNY 13,368.00 |
|
| RC216080L1 | Lenti-ORF clone of ABCB1 (Myc-DDK-tagged)-Human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) |
CNY 15,768.00 |
|
| RC216080L2 | Lenti-ORF clone of ABCB1 (mGFP-tagged)-Human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) |
CNY 15,768.00 |
|
| RC216080L3 | Lenti-ORF clone of ABCB1 (Myc-DDK-tagged)-Human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) |
CNY 15,768.00 |
|
| RC216080L4 | Lenti-ORF clone of ABCB1 (mGFP-tagged)-Human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) |
CNY 15,768.00 |
|
| RG216080 | ABCB1 (tGFP-tagged) - Human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) |
CNY 14,968.00 |
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