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TGF beta 1 (TGFB1) (NM_000660) Human Untagged Clone
CAT＃: SC119746
TGFB1 (untagged)-Human transforming growth factor, beta 1 (TGFB1)
CNY 5,488.00
| Cited in 9 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CED; DPD1; IBDIMDE; LAP; TGF-beta1; TGFB; TGFbeta |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_000660 edited
GAATTCGGCACCAGGCGTCCCTCAGGCGCCCCCATTCCGGACCAGCCCTCGGGAGTCGCC GACCCGGCCTCCCGCAAAGACTTTTCCCCAGACCTCGGGCGCACCCCCTGCACGCCGCCT TCATCCCCGGCCTGTCTCCTGAGCCCCCGCGCATCCTAGACCCTTTCTCCTCCAGGAGAC GGATCTCTCTCCGACCTGCCACAGATCCCCTATTCAAGACCACCCACCTTCTGGTACCAG ATCGCGCCCATCTAGGTTATTTCCGTGGGATACTGAGACACCCCCGGTCCAAGCCTCCCC TCCACCACTGCGCCCTTCTCCCTGAGGACCTCAGCTTTCCCTCGAGGCCCTCCTACCTTT TGCCGGGAGACCCCCAGCCCCTGCAGGGGCGGGGCCTCCCCACCACACCAGCCCTGTTCG CGCTCTCGGCAGTGCCGGGGGGCGCCGCCTCCCCCATGCCGCCCTCCGGGCTGCGGCTGC TGCCGCTGCTGCTACCGCTGCTGTGGCTACTGGTGCTGACGCCTGGCCGGCCGGCCGCGG GACTATCCACCTGCAAGACTATCGACATGGAGCTGGTGAAGCGGAAGCGCATCGAGGCCA TCCGCGGCCAGATCCTGTCCAAGCTGCGGCTCGCCAGCCCCCCGAGCCAGGGGGAGGTGC CGCCCGGCCCGCTGCCCGAGGCCGTGCTCGCCCTGTACAACAGCACCCGCGACCGGGTGG CCGGGGAGAGTGCAGAACCGGAGCCCGAGCCTGAGGCCGACTACTACGCCAAGGAGGTCA CCCGCGTGCTAATGGTGGAAACCCACAACGAAATCTATGACAAGTTCAAGCAGAGTACAC ACAGCATATATATGTTCTTCAACACATCAGAGCTCCGAGAAGCGGTACCTGAACCCGTGT TGCTCTCCCGGGCAGAGCTGCGTCTGCTGAGGCTCAAGTTAAAAGTGGAGCAGCACGTGG AGCTGTACCAGAAATACAGCAACAATTCCTGGCGATACCTCAGCAACCGGCTGCTGGCAC CCAGCGACTCGCCAGAGTGGTTATCTTTTGATGTCACCGGAGTTGTGCGGCAGTGGTTGA GCCGTGGAGGGGAAATTGAGGGCTTTCGCCTTAGCGCCCACTGCTCCTGTGACAGCAGGG ATAACACACTGCAAGTGGACATCAACGGGTTCACTACCGGCCGCCGAGGTGACCTGGCCA CCATTCATGGCATGAACCGGCCTTTCCTGCTTCTCATGGCCACCCCGCTGGAGAGGGCCC AGCATCTGCAAAGCTCCCGGCACCGCCGAGCCCTGGACACCAACTATTGCTTCAGCTCCA CGGAGAAGAACTGCTGCGTGCGGCAGCTGTACATTGACTTCCGCAAGGACCTCGGCTGGA AGTGGATCCACGAGCCCAAGGGCTACCATGCCAACTTCTGCCTCGGGCCCTGCCCCTACA TTTGGAGCCTGGACACGCAGTACAGCAAGGTCCTGGCCCTGTACAACCAGCATAACCCGG GCGCCTCGGCGGCGCCGTGCTGCGTGCCGCAGGCGCTGGAGCCGCTGCCCATCGTGTACT ACGTGGGCCGCAAGCCCAAGGTGGAGCAGCTGTCCAACATGATCGTGCGCTCCTGCAAGT GCAGCTGAGGTCCCGCCCCGCCCCGCCCCGCCCCGGCAGGCCCGGCCCCACCCCGCCCCG CCCCCGCTGCCTTGCCCATGGGGGCTGTATTTAAGGACACCCGTGCCCCAAGCCCACCTG GGGCCCCATTAAAGATGGAGAGAGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAACTCGAC >OriGene 5' read for NM_000660 unedited
TAAGATTTGTAATACGACTCACTATAGGGCGGCCGCGNAATTCGCACCAGGCGTCCCTCA GGCGCCCCCATTCCGGACCAGCCCTCGGGAGTCGCCGACCCGGCCTCCCGCAAAGACTTT TCCCCAGACCTCGGGCGCACCCCCTGCACGCCGCCTTCATCCCCGGCCTGTCTCCTGAGC CCCCGCGCATCCTAGACCCTTTCTCCTCCAGGAGACGGATCTCTCTCCGACCTGCCACAG ATCCCCTATTCAAGACCACCCACCTTCTGGTACCAGATCGCGCCCATCTAGGTTATTTCC GTGGGATACTGAGACACCCCCGGTCCAAGCCTCCCCTCCACCACTGCGCCCTTCTCCCTG AGGACCTCAGCTTTCCCTCGAGGCCCTCCTACCTTTTGCCGGGAGACCCCCAGCCCCTGC AGGGGCGGGGCCTCCCCACCACACCAGCCCTGTTCGCGCTCTCGGCAGTGCCGGGGGGCG CCGCCTCCCCCATGCCGCCCTCCGGGCTGCGGCTGCTGCCGCTGCTGCTACCGCTGCTGT GGCTACTGGTGCTGACGCCTGGCCGGCCGGCCGCGGGACTATCCACCTGCAAGACTATCG ACATGGAGCTGGTGAAGCGGAAGCGCATCGAGGCCATCCGCGGCCAGATCCTGTCCAAGC TGCGGCTCGCCAGCCCCCCGAGCCAGGGGGGAGGTGCCGCCCGGCCCGCTGCCCGAGGCC GTGCTCGCCCTGTACAACAGCACCCGCGACCGGGTGGCCGGNGAGAGTGCANAACCGGAG CCCGAGCCCTGAGCCGACTACTACGCCAAGGNAGTCACCCGCGTGCTAATGGGTGGAAAC CCACANNCGAATCTATGACAGTCTCAGCAGAGTCACACAGCATATTATATGTTCTTCACA CATCAGAGCTCCGAGAAGCGGACCTGAACCCCGTGTGCTCTCCCGGCAAAGCTGCGTCTG CTGAGGCTCAGT >OriGene 3' read for NM_000660 unedited
AACCGCGAAACCCACACTTTTNNNNNNGTTTACTTGAACCCGGCCGCAATCTANATCGAG TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCCTCTCTCCATCTTAA AGGGGGCCCCAGGGGGGCTTGGGGCACGGGTGTCCTTAAAACACCCCCCATGGGCAAGGC ACCGGGGGCGGGGCGGGGTGGGGCCGGCCCTGCCGGGGCGGGGCGGGGCGGGGCGGAACC TCATTTGCACTTGCAGGAGCCCACAATCATGTTGGACAGCTGCTCCACCTTGGGCTTGCG GCCCACGTATAACACAATGGGCAGGGGTTCCAGCGCCTGGGGAACCCAAAACGGCCCCCC CGAGGCGCCCGGGTTATGCTGGTTGTACAGGGCCAGAACCTTGCTGTACTGCGTGTCCAG CCTCCAAATGTAGGGGCAGGGCCCAAGGCAAAAGTTGGCATGGAACCCCTTGGGCTCGGG GATCCACTTCCAGCCGAGGTCCTTGCGGAAGTAAATGTACAGCTGCCGAACCCAACAGTT TTTTTCCGTGGAGCTAGAACAATATTTGGTGTCCAGGGCTCGGCGGTGCCGGAAGCTTTG CAAATGCTGGGCCCCTCTCCAGCGGGGTGGCCATGAAAAACAAGAAAAGGCCGGTTATTG CCATGAATGTTGGCCAGGTCACCTCGGCGGCCGGTAGTAAACCCTTTGATGTCCACTTGC AGGGTGTATCCCTGCTGCAAAGAAACAGGGGCCCTTAAGGCAAAGCCCTCAATTTCCCCT CCAGGGTAACCCATTGCGAAAATTTCGGGGAAATAAAAAAAACCCCTTTGGCAATCCTTG GGGTCCACAAACCGGTTGTGAGGTATCCACAGAATTTTTTTTTTTTTTGGACAGCTCCCG GCGGTCCCCTTTAACTGGAACCCAAAAAACCCACTTTTGCCGAAAAAACACGGTTTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000660 |
| Insert Size | 1870 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | TRueClone |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000660.3, NP_000651.3 |
| RefSeq Size | 2346 bp |
| RefSeq ORF | 1173 bp |
| Locus ID | 7040 |
| UniProt ID | P01137 |
| Domains | TGFb_propeptide, TGF-beta |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transcription Factors |
| Protein Pathways | Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Pancreatic cancer, Pathways in cancer, Renal cell carcinoma, TGF-beta signaling pathway |
| Gene Summary | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016] |
Citations (9)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Autocrine TGFβ1 Opposes Exogenous TGFβ1-Induced Cell Migration and Growth Arrest through Sustainment of a Feed-Forward Loop Involving MEK-ERK Signaling
,Ungefroren, H;Christl, J;Eiden, C;Wellner, U;Lehnert, H;Marquardt, J;,
Cancers
,PubMed ID 33802809
[TGFB1]
|
|
RAC1B Regulation of TGFB1 Reveals an Unexpected Role of Autocrine TGFβ1 in the Suppression of Cell Motility
,Ungefroren, H;Otterbein, H;Wellner, UF;Keck, T;Lehnert, H;Marquardt, JU;,
Cancers
,PubMed ID 33260366
[TGFB1]
|
|
Genotype-Specific Interaction of Latent TGFß Binding Protein 4 with TGFß
,Lamar, KM;Miller, T;Dellefave-Castillo, L;McNally, EM;,
PLoS ONE
,PubMed ID 26918958
[TGFB1]
|
|
High concentrations of uric acid inhibit endothelial cell migration via miR-663 which regulates PTEN by targeting TGF-ß1
,Hong, Q;Yu, S;Geng, X;Duan, L;Zheng, W;Fan, M;Chen, X;Wu, D;,
Microcirculation
,PubMed ID 25787292
[TGFB1]
|
|
Multiple MicroRNAs Derived from Chemically Synthesized Precursors Regulate Thrombospondin 1 Expression
,Dogar, AM;Semplicio, G;Guennewig, B;Hall, J;,
Nucleic Acid Ther, Jan 2014.
,PubMed ID 24444023
[TGFB1]
|
|
Suppression of Latent Transforming Growth Factor (TGF)-ß1 Restores Growth Inhibitory TGF-ß Signaling through microRNAs
,Afzal M. Dogar, Harry Towbin, and Jonathan Hall,
J. Biol. Chem., May 2011; 286: 16447 - 16458
[TGFB1]
|
|
,null,
The Journal of Biological Chemistry
,PubMed ID 21402698
[TGFB1]
|
|
Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-ß1 via cleavage of proTGF-ß1
,Atsushi Shiga, Hiroaki Nozaki, Akio Yokoseki, Megumi Nihonmatsu, Hirotoshi Kawata, Taisuke Kato, Akihide Koyama, Kunimasa Arima, Mari Ikeda, Shinichi Katada, Yasuko Toyoshima, Hitoshi Takahashi, Akira Tanaka, Imaharu Nakano, Takeshi Ikeuchi, Masatoyo Nishizawa, and Osamu Onodera,
Hum. Mol. Genet., Feb 2011; 10.1093/hmg/ddr063
[TGFB1]
|
|
Differentially expressed nucleolar transforming growth factor-ß1 target (DENTT) exhibits an inhibitory role on tumorigenesis
,Lana E. Kandalaft, Enrique Zudaire, Sergio Portal-Núñez, Frank Cuttitta, and Sonia B. Jakowlew,
Carcinogenesis, Jun 2008; 29: 1282 - 1289.
[TGFB1]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC200973 | TGFB1 (Myc-DDK-tagged)-Human transforming growth factor, beta 1 (TGFB1) |
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| RC200973L1 | Lenti ORF clone of Human transforming growth factor, beta 1 (TGFB1), Myc-DDK-tagged |
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| RC200973L2 | Lenti ORF clone of Human transforming growth factor, beta 1 (TGFB1), mGFP tagged |
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| RC200973L3 | Lenti ORF clone of Human transforming growth factor, beta 1 (TGFB1), Myc-DDK-tagged |
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| RC200973L4 | Lenti ORF clone of Human transforming growth factor, beta 1 (TGFB1), mGFP tagged |
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| RG200973 | TGFB1 (tGFP-tagged) - Human transforming growth factor, beta 1 (TGFB1) |
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