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IGFBP3 (NM_000598) Human Untagged Clone
CAT＃: SC119779
IGFBP3 (untagged)-Human insulin-like growth factor binding protein 3 (IGFBP3), transcript variant 2
CNY 2,400.00
CNY 2,950.00
| Cited in 2 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | BP-53; IBP3 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_000598 edited
GAATTCGGCACGAGGTGGGCGCTGAGGATCAGCCGCTTCCTGCCTGGATTCCACAGCTTC GCGCCGTGTACTGTCGCCCCATCCCTGCGCGCCCAGCCTGCCAAGCAGCGTGCCCCGGTT GCAGGCGTCATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGCTGGTG CTGCTCCGCGGGCCGCCGGTGGCGCGGGCTGGCGCGAGCTCGGGGGGCTTGGGTCCCGTG GTGCGCTGCGAGCCGTGCGACGCGCGTGCACTGGCCCAGTGCGCGCCTCCGCCCGCCGTG TGCGCGGAGCTGGTGCGCGAGCCGGGCTGCGGCTGCTGCCTGACGTGCGCACTGAGCGAG GGCCAGCCGTGCGGCATCTACACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCGTCG CCCGACGAGGCGCGACCGCTGCAGGCGCTGCTGGACGGCCGCGGGCTCTGCGTCAACGCT AGTGCCGTCAGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGAAATGCT AGTGAGTCGGAGGAAGACCGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACG CACCGGGTGTCTGATCCCAAGTTCCACCCCCTCCATTCAAAGATAATCATCATCAAGAAA GGGCATGCTAAAGACAGCCAGCGCTACAAAGTTGACTACGAGTCTCAGAGCACAGATACC CAGAACTTCTCCTCCGAGTCCAAGCGGGAGACAGAATATGGTCCCTGCCGTAGAGAAATG GAAGACACACTGAATCACCTGAAGTTCCTCAATGTGCTGAGTCCCAGGGGTGTACACATT CCCAACTGTGACAAGAAGGGATTTTATAAGAAAAAGCAGTGTCGCCCTTCCAAAGGCAGG AAGCGGGGCTTCTGCTGGTGTGTGGATAAGTATGGGCAGCCTCTCCCAGGCTACACCACC AAGGGGAAGGAGGACGTGCACTGCTACAGCATGCAGAGCAAGTAGACGCCTGCCGCAAGG TTAATGTGGAGCTCAAATATGCCTTATTTTGCACAAAAGACTGCCAAGGACATGACCAGC AGCTGGCTACAGCCTCGATTTATATTTCTGTTTGTGGTGAACTGATTTTTTTTAAACCAA AGTTTAGAAAGAGGTTTTTGAAATGCCTATGGTTTCTTTGAATGGTAAACTTGAGCATCT TTTCACTTTCCAGTAGTCAGCAAAGAGCAGTTTGAATTTTCTTGTCGCTTCCTATCAAAA TATTCAGAGACTCGAGCACAGCACCCAGACTTCATGCGCCCGTGGAATGCTCACCACATG TTGGTCGAAGCGGCCGACCACTGACTTTGTGACTTAGGCGGCTGTGTTGCCTATGTAGAG AACACGCTTCACCCCCACTCCCCGTACAGTGCGCACAGGCTTTATCGAGAATAGGAAAAC CTTTAAACCCCGGTCATCCGGACATCCCAACGCATGCTCCTGGAGCTCACAGCCTTCTGT GGTGTCATTTCTGAAACAAGGGCGTGGATCCCTCAACCAAGAAGAATGTTTATGTCTTCA AGTGACCTGTACTGCTTGGGGACTATTGGAGAAAATAAGGTGGAGTCCTACTTGTTTAAA AAATATGTATCTAAGAATGTTCTAGGGCACTCTGGGAACCTATAAAGGCAGGTATTTCGG GCCCTCCTCTTCAGGAATCTTCCTGAAGACATGGCCCAGTCGAAGGCCCAGGATGGCTTT TGCTGCGGCCCCGTGGGGTAGGAGGGACAGAGAGACAGGGAGAGTCAGCCTCCACATTCA GAGGCATCACAAGTAATGGCACAATTCTTCGGATGACTGCAGAAAATAGTGTTTTGTAGT TCAACAACTCAAGACGAAGCTTATTTCTGAGGATAAGCTCTTTAAAGGCAAAGCTTTATT TTCATCTCTCATCTTTTGTCCTCCTTAGCACAATGTAAAAAAGAATAGTAATATCAGAAC AGGAAGGAGGAATGGCTTGCTGGGGAGCCCATCCAGGACACTGGGAGCACATAGAGATTC ACCCATGTTTGTTGAACTTAGAGTCATTCTCATGCTTTTCTTTATAATTCACACATATAT GCAGAGAAGATATGTTCTTGTTAACATTGTATACAACATAGCCCCAAATATAGTAAGATC TATACTAGATAATCCTAGATGAAATGTTAGAGATGCTATATGATACAACTGTGGCCATGA CTGAGGAAAGGAGCTCACGCCCAGAGACTGGGCTGCTCTCCCGGAGGCCAAACCCAAGAA GGTCTGGCAAAGTCAGGCTCAGGGAGACTCTGCCCTGCTGCAGACCTCGGTGTGGACACA CGCTGCATAGAGCTCTCCTTGAAAACAGAGGGGTCTCAAGACATTCTGCCTACCTATTAG CTTTTCTTTATTTTTTTAACTTTTTGGGGGGAAAAGTATTTTTGAGAAGTTTGTCTTGCA ATGTATTTATAAATAGTAAATAAAGTTTTTACCATTAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_000598 unedited
TTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGTGGGCGCTGAGGATC AGCCGCTTCCTGCCTGGATTCCACAGCTTCGCGCCGTGTACTGTCGCCCCATCCCTGCGC GCCCAGCCTGCCAAGCAGCGTGCCCCGGTTGCAGGCGTCATGCAGCGGGCGCGACCCACG CTCTGGGCCGCTGCGCTGACTCTGCTGGTGCTGCTCCGCGGGCCGCCGGTGGCGCGGGCT GGCGCGAGCTCGGGGGGCTTGGGTCCCGTGGTGCGCTGCGAGCCGTGCGACGCGCGTGCA CTGGCCCAGTGCGCGCCTCCGCCCGCCGTGTGCGCGGAGCTGGTGCGCGAGCCGGGCTGC GGCTGCTGCCTGACGTGCGCACTGAGCGAGGGCCAGCCGTGCGGCATCTACACCGAGCGC TGTGGCTCCGGCCTTCGCTGCCAGCCGTCGCCCGACGAGGCGCGACCGCTGCAGGCGCTG CTGGACGGCCGCGGGCTCTGCGTCAACGCTAGTGCCGTCAGCCGCCTGCGCGCCTACCTG CTGCCAGCGCCGCCAGCTCCAGGAAATGCTAGTGAGTCGGAGGAAGACCGCAGCGNCCGG CAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGNGTGTCTGATCCCCAGTTCCACC CCCTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCTAAAGACAGCCAGCGCTACA AAGTTGACTACGAGTCTCAGAGCACAGATACCCAGAACTTNCTCTNCGAGTNCAGCGGGA GACGGAATATGGTCCCTGGCGTAGAAAAATGGAGAACACTGNATCACCTGAGTNCTCATG GGCTGATCCCCAGGGGTGACCATTCCCACTGGACANAAAGGGATTATAC >OriGene 3' read for NM_000598 unedited
CGCGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTAATGGTAAAAACTTTATTT ACTATTTATAAATACATTGCAAGACAAACTTCTCAAAAATACTTTTCCCCCCAAAAAGTT AAAAAAATAAAGAAAAGCTAATAGGTAGGCAGAATGTCTTGAGACCCCTCTGTTTTCAAG GAGAGCTCTATGCAGCGTGTGTCCACACCGAGGTCTGCAGCAGGGCAGAGTCTCCCTGAA CCTGACTTTTGCCAGACCCCTTTTTGGGTTGGGCCTCCGGGGAAAACACCCCCATCTTTT GGGGGGGGACCCTCTTTTCCTTAATTTGGGGCCCACGTGGGTTTAATATAGCCCCTTTTA ACACTTCTCCCTCGGAATATTCTCCACTAAAACCCTTCTATTTTTTGGGGGGGTTTTTTG GGTTACCATGGGTTAAAAAAAAACCTTTTTTTTTGGTTATTTTTTTGGGGGGGTTTTATA AAAAAAAGTGTTGAAGTTTCTCTTTTTCACCACCCACGGGGGTTTCTCTTTTTCCCCCCC CGCGCGGGGGGGGGGCCCCACAAAAACCCCCTCTTCGTGGGGGGGAAAAATATTTTTTTT TTTCCTCGGCGGGGGGGGGCGCTTAAAAGAAAAAAAAAATCCGTCTCTCTGCTCTTACTC TCCCACCCAAAACCTTTTTGTTGGTGGGGGGAAACAACCACACAAATTCTTTTTTTTCCA AAACACGCAACACCCTCCCTCTCCCCTTTTCAACAGACCTGAGCTTTCTTTTCTTTTCTT TCCCCCCCCCCCCCCCGCCTCATACTTCAATACTCTCTTGCTGGCTCCTTCTTCTTTCTT CCGCCCCTTCCTCGTCTCTCCTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000598 |
| Insert Size | 2440 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_000598.4, NP_000589.2 |
| RefSeq Size | 2620 bp |
| RefSeq ORF | 876 bp |
| Locus ID | 3486 |
| UniProt ID | P17936 |
| Domains | thyroglobulin_1, IB |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | p53 signaling pathway |
| Gene Summary | This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform b). |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Targeting insulin-like growth factor-binding protein-3 by microRNA-125b promotes tumor invasion and poor outcomes in non-small-cell lung cancer
,Wang, HH;Wang, YC;Wu, DW;Hung, CS;Chen, CY;Lee, H;,
Tumour Biol.
,PubMed ID 28378642
[IGFBP3]
|
|
IGFBP-3 methylation-derived deficiency mediates the resistance to cisplatin through the activation of the IGFIR/Akt pathway in non-small cell lung cancer
,M Cortés-Sempere, M P de Miguel, O Pernía, C Rodriguez, J de Castro Carpeño,,
Oncogene doi:10.1038/onc.2012.146
[IGFBP3]
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Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209150 | IGFBP3 (Myc-DDK-tagged)-Human insulin-like growth factor binding protein 3 (IGFBP3), transcript variant 2 |
CNY 2,400.00 |
|
| RC209150L1 | Lenti-ORF clone of IGFBP3 (Myc-DDK-tagged)-Human insulin-like growth factor binding protein 3 (IGFBP3), transcript variant 2 |
CNY 4,800.00 |
|
| RC209150L2 | Lenti-ORF clone of IGFBP3 (mGFP-tagged)-Human insulin-like growth factor binding protein 3 (IGFBP3), transcript variant 2 |
CNY 5,890.00 |
|
| RC209150L3 | Lenti-ORF clone of IGFBP3 (Myc-DDK-tagged)-Human insulin-like growth factor binding protein 3 (IGFBP3), transcript variant 2 |
CNY 5,890.00 |
|
| RC209150L4 | Lenti-ORF clone of IGFBP3 (mGFP-tagged)-Human insulin-like growth factor binding protein 3 (IGFBP3), transcript variant 2 |
CNY 5,890.00 |
|
| RG209150 | IGFBP3 (tGFP-tagged) - Human insulin-like growth factor binding protein 3 (IGFBP3), transcript variant 2 |
CNY 4,000.00 |
