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IL6R (NM_000565) Human Untagged Clone
CAT＃: SC119840
IL6R (untagged)-Human interleukin 6 receptor (IL6R), transcript variant 1
CNY 3,656.00
CNY 7,410.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1; IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>SC119840 representing NM_000565.
Blue=Insert sequence Red=Cloning site Green=Tag(s) GAATTCGGCACGAGGCGGCGCGGGGCCGAGGGACTCGCAGTGTGTGTAGAGAGCCGGGCTCCTGCGGAT GGGGGCTGCCCCCGGGGCCTGAGCCCGCCTGCCCGCCCACCGCCCCGCCCCGCCCCTGCCACCCCTGCC GCCCGGTTCCCATTAGCCTGTCCGCCTCTGCGGGACCATGGAGTGGTAGCCGAGGAGGAAGCATGCTGG CCGTCGGCTGCGCGCTGCTGGCTGCCCTGCTGGCCGCGCCGGGAGCGGCGCTGGCCCCAAGGCGCTGCC CTGCGCAGGAGGTGGCGAGAGGCGTGCTGACCAGTCTGCCAGGAGACAGCGTGACTCTGACCTGCCCGG GGGTAGAGCCGGAAGACAATGCCACTGTTCACTGGGTGCTCAGGAAGCCGGCTGCAGGCTCCCACCCCA GCAGATGGGCTGGCATGGGAAGGAGGCTGCTGCTGAGGTCGGTGCAGCTCCACGACTCTGGAAACTATT CATGCTACCGGGCCGGCCGCCCAGCTGGGACTGTGCACTTGCTGGTGGATGTTCCCCCCGAGGAGCCCC AGCTCTCCTGCTTCCGGAAGAGCCCCCTCAGCAATGTTGTTTGTGAGTGGGGTCCTCGGAGCACCCCAT CCCTGACGACAAAGGCTGTGCTCTTGGTGAGGAAGTTTCAGAACAGTCCGGCCGAAGACTTCCAGGAGC CGTGCCAGTATTCCCAGGAGTCCCAGAAGTTCTCCTGCCAGTTAGCAGTCCCGGAGGGAGACAGCTCTT TCTACATAGTGTCCATGTGCGTCGCCAGTAGTGTCGGGAGCAAGTTCAGCAAAACTCAAACCTTTCAGG GTTGTGGAATCTTGCAGCCTGATCCGCCTGCCAACATCACAGTCACTGCCGTGGCCAGAAACCCCCGCT GGCTCAGTGTCACCTGGCAAGACCCCCACTCCTGGAACTCATCTTTCTACAGACTACGGTTTGAGCTCA GATATCGGGCTGAACGGTCAAAGACATTCACAACATGGATGGTCAAGGACCTCCAGCATCACTGTGTCA TCCACGACGCCTGGAGCGGCCTGAGGCACGTGGTGCAGCTTCGTGCCCAGGAGGAGTTCGGGCAAGGCG AGTGGAGCGAGTGGAGCCCGGAGGCCATGGGCACGCCTTGGACAGAATCCAGGAGTCCTCCAGCTGAGA ACGAGGTGTCCACCCCCATGCAGGCACTTACTACTAATAAAGACGATGATAATATTCTCTTCAGAGATT CTGCAAATGCGACAAGCCTCCCAGTGCAAGCTTCTTCTTCAGTACCACTGCCCACATTCCTGGTTGCTG GAGGGAGCCTGGCCTTCGGAACGCTCCTCTGCATTGCCATTGTTCTGAGGTTCAAGAAGACGTGGAAGC TGCGGGCTCTGAAGGAAGGCAAGACAAGCATGCATCCGCCGTACTCTTTGGGGCAGCTGGTCCCGGAGA GGCCTCGACCCACCCCAGTGCTTGTTCCTCTCATCTCCCCACCGGTGTCCCCCAGCAGCCTGGGGTCTG ACAATACCTCGAGCCACAACCGACCAGATGCCAGGGACCCACGGAGCCCTTATGACATCAGCAATACAG ACTACTTCTTCCCCAGATAGCTGGCTGGGTGGCACCAGCAGCCTGGACCCTGTGGATGACAAAACACAA ACGGGCTCAGCAAAAGATGCTTCTCACTGCCATGCCAGCTTATCTCAGGGGTGTGCGGCCTTTGGCTTC ACGGAAGAGCCTTGCGGAAGGTTCTACGCCAGGGGAAAATCAGCCTGCTCCAGCTGTTCAGCTGGTTGA GGTTTCAAACCTCCCTTTCCAAATGCCCAGCTTAAAGGGGTTAGAGTGAACTTGGGCCACTGTGAAGAG AACCATATCAAGACTCTTTGGACACTCACATGGACACTCAAAAGCTGGGCAGGTTGGTGGGGGCCTCGG TGTGGAGAAGCGGCTGGCAGCCCACCCCTCAACACCTCTGCACAAGCTGCACCCTCAGGCAGGTGGGAT GGATTTCCAGCCAAAGCCTCCTCCAGCCGCCATGCTCCTGGCCCACTGCATCGTTTCATCTTCCAACTC AAACTCTTAAAACCCAAGTGCCTTAGCAAATTCTGTTTTTCTAGGCCTGGGGACGGCTTTTACTTAAAC CGCCAAGGCTGGGGGAAGAAGCTCTCTCCTCCCTTTCTTCCCTACAGTTGAAAAACAGCTGAGGGTGAG TGGGTGAATAATACAGTATCTCAGGGCCTGGTCGTTTTCAACAGAATTATAATTAGTTCCTCATTAGCA TTTTGCTAAATGTGAATGATGATCCTAGGCATTTGCTGAATACAGAGGCAACTGCATTGGCTTTGGGTT GCAGGACCTCAGGTGAGAAGCAGAGGAAGGAGAGGAGAGGGGCACAGGGTCTCTACCATCCCCTGTAGA GTGGGAGCTGAGTGGGGGATCACAGCCTCTGAAAACCAATGTTCTCTCTTCTCCACCTCCCACAAAGGA GAGCTAGCAGCAGGGAGGGCTTCTGCCATTTCTGAGATCAAAACGGTTTTACTGCAGCTTTGTTTGTTG TCAGCTGAACCTGGGTAACTAGGGAAGATAATATTAAGGAAGACAATGTGAAAAGAAAAATGAGCCTGG CAAGAATGCGTTTAAACTTGGTTTTTAAAAAAACTGCTGACTGTTTTCTCTTGAGAGGGTGGAATATCC AATATTCGCTGTGTCAGCATAGAAGTAACTTACTTAGGTGTGGGGGAAGCACCATAACTTTGTTTAGCC CAAAACCAAGTCAAGTGAAAAAGGAGGAAGAGAAAAAATATTTTCCTGCCAGGCATGGTGGCCCACGCA CTTCGGGAGGTCGAGGCAGGAGGATCACTTGAGTCCAGAAGTTTGAGATCAGCCTGGGCAATGTGATAA AACCCCATCTCTACAAAAAGCATAAAAATTAGCCAAGTGTGGTAGAGTGTGCCTGAAGTCCCAGATACT TGGGGGGCTGAGGTGGGAGGATCTCTTGAGCCTGGGAGGTCAAGGCTGCAGTGAGCCGAGATTGCACCA CTGCACTCCAGCCTGGGTGACAGAGCAAGTGAGACCCTGTCTCAAAAAAAGAAAAAAAAAAAAAAAAAA CTCGACTCTAGA >OriGene 5' read for NM_000565 unedited
CACATTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGCACGAGGCGGCGCGGGG CCGAGGGACTCGCAGTGTGTGTAGAGAGCCGGGCTCCTGCGGATGGGGGCTGCCCCCGGG GCCTGAGCCCGCCTGCCCGCCCACCGCCCCGCCCCGCCCCTGCCACCCCTGCCGCCCGGT TCCCATTAGCCTGTCCGCCTCTGCGGGACCATGGAGTGGTAGCCGAGGAGGAAGCATGCT GGCCGTCGGCTGCGCGCTGCTGGCTGCCCTGCTGGCCGCGCCGGGAGCGGCGCTGGCCCC AAGGCGCTGCCCTGCGCAGGAGGTGGCGAGAGGCGTGCTGACCAGTCTGCCAGGAGACAG CGTGACTCTGACCTGCCCGGGGGTAGAGCCGGAAGACAATGCCACTGTTCACTGGGTGCT CAGGAAGCCGGCTGCAGGCTCCCACCCCAGCAGATGGGCTGGCATGGGAAGGAGGCTGCT GCTGAGGTCGGTGCAGCTCCACGACTCTGGAAACTATTCATGCTACCGGGCCGGCCGCCC AGCTGGGACTGTGCACTTGCTGGTGGATGTTCCCCCCGAGGAGCCCCAGCTCTCCTGCTT CCGGAAGAGCCCCCTCAGCAATGTTGTTTGTGAGTGGGGTCCTCGGAGCACCCCATCCCT GACGACAAAGGCTGTGCTCTTGGTGAGGAAGTTTCAGAACAGTCCGGCCGAAGACTTCCA GGAGCCGTGCCAGTATTCCCAGGAGTCCCCAGAAGTTCTCCTGCCATTTAGCAGTCCCCG GNAGGGAGACAGCTCTTTCTACATAGTGTCCTTGTGCGTCGCAGTANTGTCNGGAAGCAA GTTCAGCAAACTCAACCTTCAGGGGGTTGGGGGAATCTGCAGCCTGATCCGCCTGNCACA TCACATCACTGCCGTGCCAGAACCCCGCTGGCTCAAGTACCTGGCAGACCCACTCCTGGA ACTATCTCTT >OriGene 3' read for NM_000565 unedited
GCCGGGCAACCCCCCCCCCCTTCCNNNNNNGNNAATTGTGAACCGGGCCGCATTCTAGAT CGGTTTTTTTTTTTTTTTTTTTTTCTTTTTTTGAGACGGGTCTCACTTGCTCTGTCACCC AGGCTGGAGTGCAGTGGTGCAATCTCGGCTCACTGCAGCCTTGACCTCCCAGGCTCAAGA GATCCTCCCACCTCAGCCCCCCAAGTATCTGGGACTTCAGGCACACTCTACCACACTTGG CTAATTTTTATGCTTTTTGTAAAGATGGGGTTTTATCACATTGCCCAGGCTGATCTCAAA CTTCTGGACTCAAGTGATCCTCCTGCCTCGACCTCCCGAAGTGCGTGGGCCACCATGCCT GGCAGGAAAATATTTTTTCTCTTCCTCCTTTTTCACTTGACTTGGTTTTGGGCTAAACAA AGTTATGGTGCTTCCCCCACACCTAAGTAAGTTACTTCTATGCTGACACAGCGAATATTG GATATTCCACCCTCTCAAGAGAAAACAGTCAGCAGTTTTTTTAAAAACCAAGTTTACACG CATTCTTGCCAGGCTCATTTTTCTTTTCACATTGCCTTCCTTAATATTATCTTCCCCTAG TTACCCAGGTTCAGCTGACCACAAACAAAGCTGCAGTAAAACCCGTTTTGATCTCAGAAA TGGCAGAAGCCCTCCCTGCTGCTAGCTCTCCCTTTGTGGGAGGTGGGAGAAGAAAGCACA TTGGTTTTAAGAGGCCTGGGATCCCCCCTTAGCTCCCACTCTACAGGGGATGTTAGAAAC CCTGGGCCCCTTCCTTTACTTTCCCTGGGTTTAACCTGAAGTCCTGCAACCAAAGCCCAT GCAGTTGCCTTTGTATTCAGCAAAAGCCTTGGATCATCTTCCCATTTACCAAAAGCCTAG GAGAACCTATTTTTATTTTGTTGAAACCACAGCCCTCGGATACTGTTTATTCCCCCCTCC CCCTACTGTTTTAATGTTGGGAAAAGAGGGGGAAAACTCTTCC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000565 |
| Insert Size | 3117 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000565.2 |
| RefSeq Size | 4176 bp |
| RefSeq ORF | 3117 bp |
| Locus ID | 3570 |
| UniProt ID | P08887 |
| Domains | ig, IGc2, IG, FN3 |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway |
| MW | 112.9 kDa |
| Gene Summary | This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Aug 2020] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Establishment of a novel cell-based assay for screening small molecule antagonists of human interleukin-6 receptor
,He, YY;Yan, Y;Zhang, C;Li, PY;Wu, P;Du, P;Zeng, DD;Fang, JS;Wang, S;Du, GH;,
Acta Pharmacol. Sin.
,PubMed ID 25345743
[IL6R]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC221874 | IL6R (Myc-DDK-tagged)-Human interleukin 6 receptor (IL6R), transcript variant 1 |
CNY 3,656.00 |
|
| RC221874L1 | Lenti ORF clone of Human interleukin 6 receptor (IL6R), transcript variant 1, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC221874L2 | Lenti ORF clone of Human interleukin 6 receptor (IL6R), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC221874L3 | Lenti ORF clone of Human interleukin 6 receptor (IL6R), transcript variant 1, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC221874L4 | Lenti ORF clone of Human interleukin 6 receptor (IL6R), transcript variant 1, mGFP tagged |
CNY 6,056.00 |
|
| RG221874 | IL6R (tGFP-tagged) - Human interleukin 6 receptor (IL6R), transcript variant 1 |
CNY 5,256.00 |
