CYP1A1 (NM_000499) Human Untagged Clone

CAT#: SC119858

CYP1A1 (untagged)-Human cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1)



  "NM_000499" in other vectors (7)

CNY 5,728.00


货期*
现货

规格
    • 10 ug

Cited in 1 publication.

Product images

经常一起买 (3)
Anti-CYP1A1 Rabbit Polyclonal Antibody
    • 100 ul

CNY 1,999.00
CNY 3,280.00


TurboFectin Transfection Reagent (1 mL in 1 vial)
    • 1 ml in 1 vial

CNY 4,090.00


Forward sequencing primer VP1.5, Reverse sequencing primer XL39, 100pmoles each
    • 100 pmol

CNY 480.00

Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Synonyms AHH; AHRR; CP11; CYP1; CYPIA1; P1-450; P450-C; P450DX
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_000499, the custom clone sequence may differ by one or more nucleotides


ATGCTTTTCCCAATCTCCATGTCGGCCACGGAGTTTCTTCTGGCCTCTGTCATCTTCTGTCTGGTATTCT
GGGTAATCAGGGCCTCAAGACCTCAGGTCCCCAAAGGCCTGAAGAATCCACCAGGGCCATGGGGCTGGCC
TCTGATTGGGCACATGCTGACCCTGGGAAAGAACCCGCACCTGGCACTGTCAAGGATGAGCCAGCAGTAT
GGGGACGTGCTGCAGATCCGAATTGGCTCCACACCCGTGGTGGTGCTGAGCGGCCTGGACACCATCCGGC
AGGCCCTGGTGCGGCAGGGCGATGATTTCAAGGGCCGGCCCGACCTCTACACCTTCACCCTCATCAGTAA
TGGTCAGAGCATGTCCTTCAGCCCAGACTCTGGACCAGTGTGGGCTGCCCGCCGGCGCCTGGCCCAGAAT
GGCCTGAAAAGTTTCTCCATTGCCTCTGACCCAGCCTCCTCAACCTCCTGCTACCTGGAAGAGCATGTGA
GCAAGGAGGCTGAGGTCCTGATAAGCACGTTGCAGGAGCTGATGGCAGGGCCTGGGCACTTTAACCCCTA
CAGGTATGTGGTGGTATCAGTGACCAATGTCATCTGTGCCATTTGCTTTGGCCGGCGCTATGACCACAAC
CACCAAGAACTGCTTAGCCTAGTCAACCTGAATAATAATTTCGGGGAGGTGGTTGGCTCTGGAAACCCAG
CTGACTTCATCCCTATTCTTCGCTACCTACCCAACCCTTCCCTGAATGCCTTCAAGGACCTGAATGAGAA
GTTCTACAGCTTCATGCAGAAGATGGTCAAGGAGCACTACAAAACCTTTGAGAAGGGCCACATCCGGGAC
ATCACAGACAGCCTGATTGAGCACTGTCAGGAGAAGCAGCTGGATGAGAACGCCAATGTCCAGCTGTCAG
ATGAGAAGATCATTAACATCGTCTTGGACCTCTTTGGAGCTGGGTTTGACACAGTCACAACTGCTATCTC
CTGGAGCCTCATGTATTTGGTGATGAACCCCAGGGTACAGAGAAAGATCCAAGAGGAGCTAGACACAGTG
ATTGGCAGGTCACGGCGGCCCCGGCTCTCTGACAGATCCCATCTGCCCTATATGGAGGCCTTCATCCTGG
AGACCTTCCGACACTCTTCCTTCGTCCCCTTCACCATCCCCCACAGCACAACAAGAGACACAAGTTTGAA
AGGCTTTTACATCCCCAAGGGGCGTTGTGTCTTTGTAAACCAGTGGCAGATCAACCATGACCAGAAGCTA
TGGGTCAACCCATCTGAGTTCCTACCTGAACGGTTTCTCACCCCTGATGGTGCTATCGACAAGGTGTTAA
GTGAGAAGGTGATTATCTTTGGCATGGGCAAGCGGAAGTGTATCGGTGAGACCATTGCCCGCTGGGAGGT
CTTTCTCTTCCTGGCTATCCTGCTGCAACGGGTGGAATTCAGCGTGCCACTGGGCGTGAAGGTGGACATG
ACCCCCATCTATGGGCTAACCATGAAGCATGCCTGCTGTGAGCACTTCCAAATGCAGCTGCGCTCTTAG


>OriGene 5' read for NM_000499 unedited
GCAACCCANTCGCACCAGGTTCCTTGGAACCTTCCCTGATCCTTGTGATCCCAGGCTCCA
AAAGTCCACCCTTCCCAGCTCAGCTCAGTACCTCAGCAGCCACCTCCAAGATCCCTACAC
TGATCATGCTTTTCCCAATCTCCATGTCGGCCACGGAGTTTCTTCTGGCCTCTGTCATTT
NCTGNCTGGTATTCTGGGTAATCAGGGCCTCAAGACCTCATGTCCCCAAAGGCCTGAAGA
ATCCACCAGGGCCATGGGGCTGGCCTCTGATTGGGCACATGCTGACCCTGGGAAAGAACC
CGCACCTGGCACTGTCAAGGATGAGCCAGCAGTATGGGGACGTGCTGCAGATCCGAATTG
GCTCCACACCCGTGGTGGTGCTGAGCGGCCTGGACACCATCCGGCAGGCCCTGGTGCGGC
AGGGCGATGATTTCAAGGGCCGGCCCGACCTCTACACCTTCACCCTCATCAGTAATGGTC
AGAGCATGTCCTTCAGCCCAGACTCTGGACCAGTGTGGGCTGCCCGCCGGCGCCTGGCCC
AGAATGGCCTGAAAAGTTTCTCCATTGCCTCTGACCCAGCCTCCTCAACCTCCTGCTACC
TGGAAGAGCATGTGAGCAAGGAGGCTGAGGTCCTGATAAGCACGTTGCANGAGCTGATGG
CAGGGCCTGGGCACTTTAACCCCTACAGGTATGTGGTGGGATCAGTGACCAATGTCATCT
GTGCCATTTGCTTTGGCCGGCGCTATGACCACAACCACCAAAAACTGCTTAGCCTAGTCA
ACCTGAATGCCCTTCAGGACCTGGATGAGGAGGTCTACAGCTTCATGCAGAAGATGGTCA
AAGAGCACTACAAAACTTTGAGAAAGCCACATCCGGGACT
>OriGene 3' read for NM_000499 unedited
CGGAGAGGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGATCTGTTCAGGAAACAGCT
ATGACTTCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTGGTTTTTTTCTGAACAATATCT
TTATTTAGCTCAGGTAGTTGTTCTTACACATTTTTGGATACCTGGGTTAGAATTTTCCCT
ATTACATTAAATCAATGGTTCTTAAGCTCTTATGCAAGCATGCAAGCTCAATGCAGGCTA
GAATAGAAGGATTGTTGTGTACAAACATTAAAAATAGACATTTTATTACAAGAGTGTAGA
GAAGGGAGACCAATAGAAGGTAATTGAAATACCCCCCCCTCACTCCAGCCCTAGTCCTGG
TGCCTGGATATGTGCACTCCCTGTGCGCTCTGATCCCCGCAGACACAAGTCCCCAGCCCC
TCCAGGACAGCAATAAGGGTCTTACAAGGCCAGAAGGCAGCCCTGTTTGTTCCTGCCTGC
AGGAAGGGCAGAGGAATGTGATGTTCCCAGGAACTGTGTCCTAGACCCATAGGGTCAGAT
TGCTCAGCCTAGTTCAAGCAGTGAGACTACCTCTGTGCCAGTATCCTGGGCTGTCTCTTC
CNTTCACTCTTGGCAGCTCCCAATTGTCAAAGATTGGACAGGGGTCTGGGTTGGGCTAGT
CTAACTTGCTGAAGCCAGTCAGCACCCTCACAGAGCCAGCTAGGTACTGGGCCCAGGGGC
TTCCAGAGAGTTCTTCAGAGCTTCTCAGAGGCCTAAGGACCTCCTAACCCTAGCAGGGCC
TCCTGCTCAAGCACAACT
Restriction Sites NotI-NotI     
ACCN NM_000499
Insert Size 2310 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq NM_000499.2, NP_000490.1
RefSeq Size 2602 bp
RefSeq ORF 1539 bp
Locus ID 1543
UniProt ID P04798
Domains p450
Protein Families Druggable Genome, P450, Transmembrane
Protein Pathways Metabolism of xenobiotics by cytochrome P450, Retinol metabolism, Tryptophan metabolism
Gene Summary This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 encode the same isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (1)

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