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alpha Synuclein (SNCA) (NM_000345) Human Untagged Clone
CAT＃: SC119919
SNCA (untagged)-Human synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1
CNY 1,200.00
CNY 2,950.00
| Cited in 8 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | NACP; PARK1; PARK4; PD1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC119919 sequence for NM_000345 edited (data generated by NextGen Sequencing)
ATGGATGTATTCATGAAAGGACTTTCAAAGGCCAAGGAGGGAGTTGTGGCTGCTGCTGAG AAAACCAAACAGGGTGTGGCAGAAGCAGCAGGAAAGACAAAAGAGGGTGTTCTCTATGTA GGCTCCAAAACCAAGGAGGGAGTGGTGCATGGTGTGGCAACAGTGGCTGAGAAGACCAAA GAGCAAGTGACAAATGTTGGAGGAGCAGTGGTGACGGGTGTGACAGCAGTAGCCCAGAAG ACAGTGGAGGGAGCAGGGAGCATTGCAGCAGCCACTGGCTTTGTCAAAAAGGACCAGTTG GGCAAGAATGAAGAAGGAGCCCCACAGGAAGGAATTCTGGAAGATATGCCTGTGGATCCT GACAATGAGGCTTATGAAATGCCTTCTGAGGAAGGGTATCAAGACTACGAACCTGAAGCC TAA Clone variation with respect to NM_000345.3 >OriGene 5' read for NM_000345 unedited
GGTCGAATTTGTATACGACTCCTATAGGCGGCCCGCGAATTCGCACGAGGAAGGGGCCCA AGAGAGGGGGCGAGCGACCGAGCGCCGCGACGCGGAAGTGAGGTGCGTGCGGGCTGCAGC GCAGACCCCGGCCCGGCCCCTCCGAGAGCGTCCTGGGCGCTCCCTCACGCCTTGCCTTCA AGCCTTCTGCCTTTCCACCCTCGTGAGCGGAGAACTGGGAGTGGCCATTCGACGACAGTG TGGTGTAAAGGAATTCATTAGCCATGGATGTATTCATGAAAGGACTTTCAAAGGCCAAGG AGGGAGTTGTGGCTGCTGCTGAGAAAACCAAACAGGGTGTGGCAGAAGCAGCAGGAAAGA CAAAAGAGGGTGTTCTCTATGTAGGCTCCAAAACCAAGGAGGGAGTGGTGCATGGTGTGG CAACAGTGGCTGAGAAGACCAAAGAGCAAGTGACAAATGTTGGAGGAGCAGTGGTGACGG GTGTGACAGCAGTAGCCCAGAAGACAGTGGAGGGAGCAGGGAGCATTGCAGCAGCCACTG GCTTTGTCAAAAAGGACCAGTTGGGCAAGAATGAAGAAGGAGCCCCACAGGAAGGAATTC TGGAAGATATGCCTGTGGATCCTGACAATGAGGCTTATGAAATGCCTTCTGAGGAAGGGT ATCAAGACTACGAACCTGAAGCCTAAGAAATATCTTTGCTCCCAGTTTCTTGAGATCTGC TGACAGATGTTCCATCCTGTACAAGTGCTCAGTTCCAATGTGCCCAGTCATGACATTTCT CANAGTTTTTACAGTGTATCTCGAAAGTCTTCATCAGCAGTGATTGAAGTATCTGCACCT GCCCNCACTCAGCATTNNCGTGCTTCCCTTTCACTGNAGTGAATACATGGTAGCAGGTCC TTGTGTGCTGTGGATTNTGTGC >OriGene 3' read for NM_000345 unedited
GATGGAACCTCCATTGCCAGNANAGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGAT CTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGNNTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTTTTTTTTATTTTGGCAATGAAATAACGTTTTATTTTAATTC TCACCATTTATATACAAACCCAAGTGAATTATTCACATCGCAAAAGGGGAAAATTTCATA TTTAGTATTTATAGGGGCATAGTTTCATGCTCACATATTTTTAAGTTTTATATATTTTAA CAAATTTCACAATACGTCATTTTTCTTAAACAGTTTCATTAAAAGACACCTAAAAATCTT ATAATATATGATAGCAAATCACTAACAACTTTTGAACAACAGCAACAAAAAAATAGGGGG GATTTAAAAATAAGGGGGAGCCACTTAGGGGTTTTTAATTTGTTTTAACATCGTAGATTG AAGCCACAAAATCCACAGCACACAAAGACCCTGCTACCATGTATTCACTTCAGGGAAAGG GAACCACCGAAATGCTGAGTGGGGGCAGGTACAAATACTTCAATCACTGGTGATGGAAGA CTTCGAGATACACTGTAAAAACTTTGAGAAATGTCATGACTGGGCACATTGGAACTGAGC ACTTGTACAGTATGGAACATCTGTCAACAGATCTCAAAAAACTGGGAGCAAAGATATTTC TTAGGCTTCAGGTTCGGAGTCTTGATACCCTTCCTCAAAAGGCATTTCATAAGCCTTATT GTCAGGATACACAAGCATTTTTTTCCAAAATTCCTTCCTGTGGGGGCTCCTTCTTAATAC TTTGACAAACTGTTCTTTTTTGACAAAGCCAGGGGCTGTTGGAATGCTTCCTGCTCCA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000345 |
| Insert Size | 423 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000345.2, NP_000336.1 |
| RefSeq Size | 1543 bp |
| RefSeq ORF | 423 bp |
| Locus ID | 6622 |
| UniProt ID | P37840 |
| Domains | Synuclein |
| Protein Families | Druggable Genome |
| Protein Pathways | Alzheimer's disease, Parkinson's disease |
| Gene Summary | Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016] Transcript Variant: This variant (1, also known as NACP140) is the longest transcript and encodes the longer isoform (NACP140). Variants 1, 2, and 3 all encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (8)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Cytotoxicity and Mitochondrial Dysregulation Caused by α-Synuclein in Dictyostelium discoideum
,Fernando, S;Allan, CY;Mroczek, K;Pearce, X;Sanislav, O;Fisher, PR;Annesley, SJ;,
Cells
,PubMed ID 33066427
[alpha Synuclein]
|
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A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion
,Zhang, M;Liu, L;Lin, X;Wang, Y;Li, Y;Guo, Q;Li, S;Sun, Y;Tao, X;Zhang, D;Lv, X;Zheng, L;Ge, L;,
Cell
,PubMed ID 32272059
[alpha Synuclein]
|
|
α-Synuclein impairs ferritinophagy in the retinal pigment epithelium: Implications for retinal iron dyshomeostasis in Parkinson's disease
,Baksi, S;Singh, N;,
Sci Rep
,PubMed ID 28993630
[alpha Synuclein]
|
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Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease
,Baksi, S;Tripathi, AK;Singh, N;,
Free Radic. Biol. Med.
,PubMed ID 27343690
[alpha Synuclein]
|
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A Bacteriophage Capsid Protein Provides a General Amyloid Interaction Motif (GAIM) That Binds and Remodels Misfolded Protein Assemblies
,Krishnan, R;Tsubery, H;Proschitsky, MY;Asp, E;Lulu, M;Gilead, S;Gartner, M;Waltho, J;Davis, PJ;Hounslow, AM;Kirschner, DA;Inouye, H;Myszka, DG;Wright, J;Solomon, B;Fisher, RA;,
J. Mol. Biol. April 2014
,PubMed ID 24768993
[alpha Synuclein]
|
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Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression
,null,
Molecular and Cellular Neurosciences
,PubMed ID 22155155
[alpha Synuclein]
|
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miR-107 Regulates Granulin/Progranulin with Implications for Traumatic Brain Injury and Neurodegenerative Disease
,Wang-Xia Wang, Bernard R. Wilfred, Sindhu K. Madathil, Guiliang Tang, Yanling Hu, James Dimayuga, Arnold J. Stromberg, Qingwei Huang, Kathryn E. Saatman, and Peter T. Nelson,
Am. J. Pathol., Jul 2010; 177: 334 - 345
[alpha Synuclein]
|
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miR-107 Regulates Granulin/Progranulin with Implications for Traumatic Brain Injury and Neurodegenerative Disease
,null,
The American Journal of Pathology
,PubMed ID 20489155
[alpha Synuclein]
|
Documents
| Product Manuals |
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| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC210606 | SNCA (Myc-DDK-tagged)-Human synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1 |
CNY 1,200.00 |
|
| RC210606L1 | Lenti ORF clone of Human synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1, Myc-DDK-tagged |
CNY 3,600.00 |
|
| RC210606L2 | Lenti ORF clone of Human synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1, mGFP tagged |
CNY 3,600.00 |
|
| RC210606L3 | Lenti ORF clone of Human synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1, Myc-DDK-tagged |
CNY 3,600.00 |
|
| RC210606L4 | Lenti ORF clone of Human synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1, mGFP tagged |
CNY 3,600.00 |
|
| RG210606 | SNCA (tGFP-tagged) - Human synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1 |
CNY 2,800.00 |
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