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BACE1 (NM_138972) Human Untagged Clone
CAT＃: SC120577
BACE1 (untagged)-Human beta-site APP-cleaving enzyme 1 (BACE1), transcript variant b
CNY 3,656.00
CNY 7,700.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ASP2; BACE; HSPC104 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_138972, the custom clone sequence may differ by one or more nucleotides
ATGGCCCAAGCCCTGCCCTGGCTCCTGCTGTGGATGGGCGCGGGAGTGCTGCCTGCCCACGGCACCCAGC ACGGCATCCGGCTGCCCCTGCGCAGCGGCCTGGGGGGCGCCCCCCTGGGGCTGCGGCTGCCCCGGGAGAC CGACGAAGAGCCCGAGGAGCCCGGCCGGAGGGGCAGCTTTGTGGAGATGGTGGACAACCTGAGGGGCAAG TCGGGGCAGGGCTACTACGTGGAGATGACCGTGGGCAGCCCCCCGCAGACGCTCAACATCCTGGTGGATA CAGGCAGCAGTAACTTTGCAGTGGGTGCTGCCCCCCACCCCTTCCTGCATCGCTACTACCAGAGGCAGCT GTCCAGCACATACCGGGACCTCCGGAAGGGTGTGTATGTGCCCTACACCCAGGGCAAGTGGGAAGGGGAG CTGGGCACCGACCTGGTAAGCATCCCCCATGGCCCCAACGTCACTGTGCGTGCCAACATTGCTGCCATCA CTGAATCAGACAAGTTCTTCATCAACGGCTCCAACTGGGAAGGCATCCTGGGGCTGGCCTATGCTGAGAT TGCCAGGCTTTGTGGTGCTGGCTTCCCCCTCAACCAGTCTGAAGTGCTGGCCTCTGTCGGAGGGAGCATG ATCATTGGAGGTATCGACCACTCGCTGTACACAGGCAGTCTCTGGTATACACCCATCCGGCGGGAGTGGT ATTATGAGGTGATCATTGTGCGGGTGGAGATCAATGGACAGGATCTGAAAATGGACTGCAAGGAGTACAA CTATGACAAGAGCATTGTGGACAGTGGCACCACCAACCTTCGTTTGCCCAAGAAAGTGTTTGAAGCTGCA GTCAAATCCATCAAGGCAGCCTCCTCCACGGAGAAGTTCCCTGATGGTTTCTGGCTAGGAGAGCAGCTGG TGTGCTGGCAAGCAGGCACCACCCCTTGGAACATTTTCCCAGTCATCTCACTCTACCTAATGGGTGAGGT TACCAACCAGTCCTTCCGCATCACCATCCTTCCGCAGCAATACCTGCGGCCAGTGGAAGATGTGGCCACG TCCCAAGACGACTGTTACAAGTTTGCCATCTCACAGTCATCCACGGGCACTGTTATGGGAGCTGTTATCA TGGAGGGCTTCTACGTTGTCTTTGATCGGGCCCGAAAACGAATTGGCTTTGCTGTCAGCGCTTGCCATGT GCACGATGAGTTCAGGACGGCAGCGGTGGAAGGCCCTTTTGTCACCTTGGACATGGAAGACTGTGGCTAC AACATTCCACAGACAGATGAGTCAACCCTCATGACCATAGCCTATGTCATGGCTGCCATCTGCGCCCTCT TCATGCTGCCACTCTGCCTCATGGTGTGTCAGTGGCGCTGCCTCCGCTGCCTGCGCCAGCAGCATGATGA CTTTGCTGATGACATCTCCCTGCTGAAGTGA >OriGene 5' read for NM_138972 unedited
TACTATAGGGGCGGCCGCGAATTCGCACGAGGTGCGGATCTCCCCTGACCGCTCTCCACA GCCCGGACCCGGGGGCTGGCCCAGGGCCCTGCAGGCCCTGGCGTCCTGATGCCCCCAAGC TCCCTCTCCTGAGAAGCCACCAGCACCACCCAGACTTGGGGGCAGGCGCCAGGGACGGAC GTGGGCCAGTGCGAGCCCAGAGGGCCCGAAGGCCGGGGCCCACCATGGCCCAAGCCCTGC CCTGGCTCCTGCTGTGGATGGGCGCGGGAGTGCTGCCTGCCCACGGCACCCAGCACGGCA TCCGGCTGCCCCTGCGCAGCGGCCTGGGGGGCGCCCCCCTGGGGCTGCGGCTGCCCCGGG AGACCGACGAAGAGCCCGAGGAGCCCGGCCGGAGGGGCAGCTTTGTGGAGATGGTGGACA ACCTGAGGGGCAAGTCGGGGCAGGGCTACTACGTGGAGATGACCGTGGGCAGCCCCCCGC AGACGCTCAACATCCTGGTGGATACAGGCAGCAGTAACTTTGCAGTGGGTGCTGCCCCCC ACCCCTTCCTGCATCGCTACTACCAGAGGCAGCTGTCCAGCACATACCGGGACCTCCGGA AGGGTGTGTATGTGCCCTACACCCAGNGCAAGTGGGAAGGGGAGCTGGGCACCGACCTGT TAAGCATTCCCCATGGCCCCAACGTCACTGTGCGTGCCCACATTGCTGCCATCACTGAAT CANACAGGTTCTTCATCAACGGCTCCACTGGNGAAGCATCCTGGGGCTGGCCTATGCTGA GATGCCAAGCCTGACGACTCCCTGGAGCCTTTNTTTGACTCTCTGGTAAGCAGAACCACG TTCCAACCTCTTCTCCTGCACCTTTGGGG >OriGene 3' read for NM_138972 unedited
GGAATATTATGNACGCGGCCGCATTCTANNATCGAGTTTTTTTTTTTTTTTTTTTTTTTT CTTATTGAATATTTTACTGTGTTAACGCTCATTATTTATACAGACATTAGGTTTACAGAA TATTCTGTTTTACATCACCAAAATTCACAGTCCGAGAATAACAACATAACCAGGTCCCAA TTCCTCCATGCACCCCACAAGCTTCTGTCCACCCTATTTTCTGGACAGAAATTAGCACAA CCCACAGGTTTTTCCTGGGCCAAGTCTTCCTTTGCTGCCACTGTCTTGGCTTCTAATCAA GCTCTGACAGGCCAACATTGTGAAGTCCTCACCCTTTCCCATTCACTTCTGGTCTCCTAG TCTAGCTAATCCCCCTCCCCCAGAAGGTTAAGGCAGTTGGTTCACAACCAAGTTGTTTGG TGACCTTGGGTGAGCTCCAGACAGGCACTGGGGTGAGGAGATGTCTGTGCAAAATTACTT GTAGAATGATCTTGGGATGCTGGATTTTAATTTTTGAAGCAAGAAAGTTAGGGGGGGACA TATTTCCTGTCCTGGGAAAAATGGAGACCAAAGTGATATTAAGAAAGTAGTTTGGATTTC AAATTTATAAATCACTTGCTCTGTGGGTAGCTATCAGGAACTAGATCATTTTCCACCTCT GCTTATTGTACTTCTTAATTTTAGGTTTTATACCTGGGAAAGCTGTGACTCTATTAGAGC TTTGAATCTTTTCCTATCCTTTTATCTTTACTCCTACAGGGAATGGCCTCAGCTCCCTTC TCTTTTAGATTAAACAAGTAAAAACTAAGAGTTAACTTTTTAAAAAAACTGACTCCCGGG AAAGGACATTATTATATTACCAATAGCTGATTTTTTTTTTCATTCTGGGACCTAAAAGCT TACAGTACTAN |
| Restriction Sites | NotI-NotI |
| ACCN | NM_138972 |
| Insert Size | 5650 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_138972.2, NP_620428.1 |
| RefSeq Size | 5775 bp |
| RefSeq ORF | 1431 bp |
| Locus ID | 23621 |
| UniProt ID | P56817 |
| Domains | asp |
| Protein Families | Druggable Genome, Protease, Transmembrane |
| Protein Pathways | Alzheimer's disease |
| Gene Summary | This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015] Transcript Variant: This variant (b) has an alternate splice site in the coding region, compared to variant a. The resulting isoform (B) lacks an internal segment, compared to isoform A. This isoform (B) may not undergo proteolytic processing similar to isoform A. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
miR-29c regulates BACE1 protein expression.
,null,
Brain research
,PubMed ID 21565331
[BACE1]
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Resources
Other Versions
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| RC220265L3 | Lenti-ORF clone of BACE1 (Myc-DDK-tagged)-Human beta-site APP-cleaving enzyme 1 (BACE1), transcript variant b |
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| RC220265L4 | Lenti-ORF clone of BACE1 (mGFP-tagged)-Human beta-site APP-cleaving enzyme 1 (BACE1), transcript variant b |
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| RG220265 | BACE1 (tGFP-tagged) - Human beta-site APP-cleaving enzyme 1 (BACE1), transcript variant b |
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