United States
Germany
Japan
United Kingdom
China
IL1 beta (IL1B) (NM_000576) Human Untagged Clone
CAT＃: SC122566
IL1B (untagged)-Human interleukin 1, beta (IL1B)
CNY 3,600.00
| Cited in 3 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | IL-1; IL1-BETA; IL1beta; IL1F2 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_000576 edited
GAATTCCCGGGATATCGTCGACCCACGCGTCCGCCCACGCGTCCGCCCACGCGTCCGACCAAACCTCTTC GAGGCACAAGGCACAACAGGCTGCTCTGGGATTCTCTTCAGCCAATCTTCATTGCTCAAGTGTCTGAAGC AGCCATGGCAGAAGTACCTGAGCTCGCCAGTGAAATGATGGCTTATTACAGTGGCAATGAGGATGACTTG TTCTTTGAAGCTGATGGCCCTAAACAGATGAAGTGCTCCTTCCAGGACCTGGACCTCTGCCCTCTGGATG GCGGCATCCAGCTACGAATCTCCGACCACCACTACAGCAAGGGCTTCAGGCAGGCCGCGTCAGTTGTTGT GGCCATGGACAAGCTGAGGAAGATGCTGGTTCCCTGCCCACAGACCTTCCAGGAGAATGACCTGAGCACC TTCTTTCCCTTCATCTTTGAAGAAGAACCTATCTTCTTCGACACATGGGATAACGAGGCTTATGTGCACG ATGCACCTGTACGATCACTGAACTGCACGCTCCGGGACTCACAGCAAAAAAGCTTGGTGATGTCTGGTCC ATATGAACTGAAAGCTCTCCACCTCCAGGGACAGGATATGGAGCAACAAGTGGTGTTCTCCATGTCCTTT GTACAAGGAGAAGAAAGTAATGACAAAATACCTGTGGCCTTGGGCCTCAAGGAAAAGAATCTGTACCTGT CCTGCGTGTTGAAAGATGATAAGCCCACTCTACAGCTGGAGAGTGTAGATCCCAAAAATTACCCAAAGAA GAAGATGGAAAAGCGATTTGTCTTCAACAAGATAGAAATCAATAACAAGCTGGAATTTGAGTCTGCCCAG TTCCCCAACTGGTACATCAGCACCTCTCAAGCAGAAAACATGCCCGTCTTCCTGGGAGGGACCAAAGGCG GCCAGGATATAACTGACTTCACCATGCAATTTGTGTCTTCCTAAAGAGAGCTGTACCCAGAGAGTCCTGT GCTGAATGTGGACTCAATCCCTAGGGCTGGCAGAAAGGGAACAGAAAGGTTTTTGAGTACGGCTATAGCC TGGACTTTCCTGTTGTCTACACCAATGCCCAACTGCCTGCCTTAGGGTAGTGCTAAGAGGATCTCCTGTC CATCAGCCAGGACAGTCAGCTCTCTCCTTTCAGGGCCAATCCCCAGCCCTTTTGTTGAGCCAGGCCTCTC TCACCTCTCCTACTCACTTAAAGCCCGCCTGACAGAAACCACGGCCACATTTGGTTCTAAGAAACCCTCT GTCATTCGCTCCCACATTCTGATGAGCAACCGCTTCCCTATTTATTTATTTATTTGTTTGTTTGTTTTAT TCATTGGTCTAATTTATTCAAAGGGGGCAAGAAGTAGCAGTGTCTGTAAAAGAGCCTAGTTTTTAATAGC TATGGAATCAATTCAATTTGGACTGGTGTGCTCTCTTTAAATCAAGTCCTTTAATTAAGACTGAAAATAT ATAAGCTCAGATTATTTAAATGGGAATATTTATAAATGAGCAAATATCATACTGTTCAATGGTTCTGAAA TAAACTTCACTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGGGCGGCCGC >OriGene 5' read for NM_000576 unedited
NGCCGTTCAAATTTGTAAACGACTCATATAGGCGGCCGCGNATTCCCGGGNAATCGTCGA CCCACGCGTCCGCCCACGCGTCCGCCCACGCGTCCGACCAAACCTCTTCGAGGCACAAGG CACAACAGGCTGCTCTGGGATTCTCTTCAGCCAATCTTCATTGCTCAAGTGTCTGAAGCA GCCATGGCAGAAGTACCTGAGCTCGCCAGTGAAATGATGGCTTATTACAGTGGCAATGAG GATGACTTGTTCTTTGAAGCTGATGGCCCTAAACAGATGAAGTGCTCCTTCCAGGACCTG GACCTCTGCCCTCTGGATGGCGGCATCCAGCTACGAATCTCCGACCACCACTACAGCAAG GGCTTCAGGCAGGCCGCGTCAGTTGTTGTGGCCATGGACAAGCTGAGGAAGATGCTGGTT CCCTGCCCACAGACCTTCCAGGAGAATGACCTGAGCACCTTCTTTCCCTTCATCTTTGAA GAAGAACCTATCTTCTTCGACACATGGGATAACGAGGCTTATGTGCACGATGCACCTGTA CGATCACTGAACTGCACGCTCCGGGACTCACAGCAAANAAGCTTGGTGATGTCTGGTCCA TATGAACTGAAAGCTCTCCACCTCCAGGGACAGGATATGGAGCAACAAGTGGTGTTCTCC ATGTCCTTTGTACAAGGAGAAGAAAGTAATGACAAAATACCTGTGGCCTTGGGCCTCAAG GAAAAGAATCTGTACCTGTCCTGCGTGTTGAAAGATGATAAGCCCACTCTACAGCTGGAG AGTGTAGATCCCAAAAATTACCCAAAGAAGAAGATGGAAAAGCGATTTGTCTTNCAACAG ATAGAAATCAATAACAAGCTGGAATTNGAGTCTGCCCAGTTCCCCCACTGGTAC |
| Restriction Sites | Please inquire |
| ACCN | NM_000576 |
| Insert Size | 1522 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000576.2, NP_000567.1 |
| RefSeq Size | 1498 bp |
| RefSeq ORF | 810 bp |
| Locus ID | 3553 |
| UniProt ID | P01584 |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | Alzheimer's disease, Apoptosis, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, MAPK signaling pathway, NOD-like receptor signaling pathway, Prion diseases, Toll-like receptor signaling pathway, Type I diabetes mellitus |
| Gene Summary | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020] |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
The Homeoprotein DLX4 Stimulates NF-?B Activation and CD44-Mediated Tumor-Mesothelial Cell Interactions in Ovarian Cancer
,Haria, D;Trinh, BQ;Ko, SY;Barengo, N;Liu, J;Naora, H;,
Am. J. Pathol.
,PubMed ID 26067154
[IL1B]
|
|
Caspase-1 and IL-1? Processing in a Teleost Fish
,null,
PLoS ONE
,PubMed ID 23226286
[IL1B]
|
|
Intracellular interleukin-1 mediates interleukin-8 production induced by Chlamydia trachomatis infection via a mechanism independent of type I interleukin-1 receptor
,Wen Cheng, Pooja Shivshankar, Youmin Zhong, Ding Chen, Zhongyu Li, and Guangming Zhong,
Infect. Immun., Dec 2007; 10.1128/IAI.01313-07
[IL1B]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC202079 | IL1B (Myc-DDK-tagged)-Human interleukin 1, beta (IL1B) |
CNY 3,600.00 |
|
| RC202079L1 | Lenti ORF clone of Human interleukin 1, beta (IL1B), Myc-DDK-tagged |
CNY 6,000.00 |
|
| RC202079L2 | Lenti ORF clone of Human interleukin 1, beta (IL1B), mGFP tagged |
CNY 6,000.00 |
|
| RC202079L3 | Lenti ORF clone of Human interleukin 1, beta (IL1B), Myc-DDK-tagged |
CNY 6,000.00 |
|
| RC202079L4 | Lenti ORF clone of Human interleukin 1, beta (IL1B), mGFP tagged |
CNY 6,000.00 |
|
| RG202079 | IL1B (tGFP-tagged) - Human interleukin 1, beta (IL1B) |
CNY 5,200.00 |
其它IL1 beta产品
