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STAT3 (NM_139276) Human Untagged Clone
CAT＃: SC124165
STAT3 (untagged)-Human signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1
CNY 8,472.00
| Cited in 11 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ADMIO; ADMIO1; APRF; HIES |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_139276 edited
GAATTCGGCACCAGCAGGCACCCCGGCTTGGCGCTGTCTCTCCCCCTCGGCTCGGAGAGG CCCTTCGGCCTGAGGGAGCCTCGCCGCCCGTCCCCGGCACACGCGCAGCCCCGGCCTCTC GGCCTCTGCCGGAGAAACAGTTGGGACCCCTGATTTTAGCAGGATGGCCCAATGGAATCA GCTACAGCAGCTTGACACACGGTACCTGGAGCAGCTCCATCAGCTCTACAGTGACAGCTT CCCAATGGAGCTGCGGCAGTTTCTGGCCCCTTGGATTGAGAGTCAAGATTGGGCATATGC GGCCAGCAAAGAATCACATGCCACTTTGGTGTTTCATAATCTCCTGGGAGAGATTGACCA GCAGTATAGCCGCTTCCTGCAAGAGTCGAATGTTCTCTATCAGCACAATCTACGAAGAAT CAAGCAGTTTCTTCAGAGCAGGTATCTTGAGAAGCCAATGGAGATTGCCCGGATTGTGGC CCGGTGCCTGTGGGAAGAATCACGCCTTCTACAGACTGCAGCCACTGCGGCCCAGCAAGG GGGCCAGGCCAACCACCCCACAGCAGCCGTGGTGACGGAGAAGCAGCAGATGCTGGAGCA GCACCTTCAGGATGTCCGGAAGAGAGTGCAGGATCTAGAACAGAAAATGAAAGTGGTAGA GAATCTCCAGGATGACTTTGATTTCAACTATAAAACCCTCAAGAGTCAAGGAGACATGCA AGATCTGAATGGAAACAACCAGTCAGTGACCAGGCAGAAGATGCAGCAGCTGGAACAGAT GCTCACTGCGCTGGACCAGATGCGGAGAAGCATCGTGAGTGAGCTGGCGGGGCTTTTGTC AGCGATGGAGTACGTGCAGAAAACTCTCACGGACGAGGAGCTGGCTGACTGGAAGAGGCG GCAACAGATTGCCTGCATTGGAGGCCCGCCCAACATCTGCCTAGATCGGCTAGAAAACTG GATAACGTCATTAGCAGAATCTCAACTTCAGACCCGTCAACAAATTAAGAAACTGGAGGA GTTGCAGCAAAAAGTTTCCTACAAAGGGGACCCCATTGTACAGCACCGGCCGATGCTGGA GGAGAGAATCGTGGAGCTGTTTAGAAACTTAATGAAAAGTGCCTTTGTGGTGGAGCGGCA GCCCTGCATGCCCATGCATCCTGACCGGCCCCTCGTCATCAAGACCGGCGTCCAGTTCAC TACTAAAGTCAGGTTGCTGGTCAAATTCCCTGAGTTGAATTATCAGCTTAAAATTAAAGT GTGCATTGACAAAGACTCTGGGGACGTTGCAGCTCTCAGAGGATCCCGGAAATTTAACAT TCTGGGCACAAACACAAAAGTGATGAACATGGAAGAATCCAACAACGGCAGCCTCTCTGC AGAATTCAAACACTTGACCCTGAGGGAGCAGAGATGTGGGAATGGGGGCCGAGCCAATTG TGATGCTTCCCTGATTGTGACTGAGGAGCTGCACCTGATCACCTTTGAGACCGAGGTGTA TCACCAAGGCCTCAAGATTGACCTAGAGACCCACTCCTTGCCAGTTGTGGTGATCTCCAA CATCTGTCAGATGCCAAATGCCTGGGCGTCCATCCTGTGGTACAACATGCTGACCAACAA TCCCAAGAATGTAAACTTTTTTACCAAGCCCCCAATTGGAACCTGGGATCAAGTGGCCGA GGTCCTGAGCTGGCAGTTCTCCTCCACCACCAAGCGAGGACTGAGCATCGAGCAGCTGAC TACACTGGCAGAGAAACTCTTGGGACCTGGTGTGAATTATTCAGGGTGTCAGATCACATG GGCTAAATTTTGCAAAGAAAACATGGCTGGCAAGGGCTTCTCCTTCTGGGTCTGGCTGGA CAATATCATTGACCTTGTGAAAAAGTACATCCTGGCCCTTTGGAACGAAGGGTACATCAT GGGCTTTATCAGTAAGGAGCGGGAGCGGGCCATCTTGAGCACTAAGCCTCCAGGCACCTT CCTGCTAAGATTCAGTGAAAGCAGCAAAGAAGGAGGCGTCACTTTCACTTGGGTGGAGAA GGACATCAGCGGTAAGACCCAGATCCAGTCCGTGGAACCATACACAAAGCAGCAGCTGAA CAACATGTCATTTGCTGAAATCATCATGGGCTATAAGATCATGGATGCTACCAATATCCT GGTGTCTCCACTGGTCTATCTCTATCCTGACATTCCCAAGGAGGAGGCATTCGGAAAGTA TTGTCGGCCAGAGAGCCAGGAGCATCCTGAAGCTGACCCAGGTAGCGCTGCCCCATACCT GAAGACCAAGTTTATCTGTGTGACACCAACGACCTGCAGCAATACCATTGACCTGCCGAT GTCCCCCCGCACTTTAGATTCATTGATGCAGTTTGGAAATAATGGTGAAGGTGCTGAACC CTCAGCAGGAGGGCAGTTTGAGTCCCTCACCTTTGACATGGAGTTGACCTCGGAGTGCGC TACCTCCCCCATGTGAGGAGCTGAGAACGGAAGCTGCAGAAAGATACGACTGAGGCGCCT ACCTGCATTCTGCCACCCCTCACACAGCCAAACCCCAGATCATCTGAAACTACTAACTTT GTGGTTCCAGATTTTTTTTAATCTCCTACTTCTGCTATCTTTGAGCAATCTGGGCACTTT TAAAAATAGAGAAATGAGTGAATGTGGGTGATCTGCTTTTATCTAAATGCAAATAAGGAT GTGTTCTCTGAGACCCATGATCAGGGGATGTGGCGGGGGGTGGCTAGAGGGAGAAAAAGG AAATGTCTTGTGTTGTTTTGTTCCCCTGCCCTCCTTTCTCAGCAGCTTTTTGTTATTGTT GTTGTTGTTCTTAGACAAGTGCCTCCTGGTGCCTGCGGCATCCTTCTGCCTGTTTCTGTA AGCAAATGCCACAGGCCACCTATAGCTACATACTCCTGGCATTGCACTTTTTAACCTTGC TGACATCCAAATAGAAGATAGGACTATCTAAGCCCTAGGTTTCTTTTTAAATTAAGAAAT AATAACAATTAAAGGGCAAAAAACACTGTATCAGCATAGCCTTTCTGTATTTAAGAAACT TAAGCAGCCGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGG ATCATAAGGTCAGGAGATCAAGACCATCC >OriGene 5' read for NM_139276 unedited
AAAAAAAAAAAAAAAAAAAAAAAAAAANNGCTGTTCACAATTGTATACGACTCCTATAGG CGGCCGCGNAATCGGCACCAGCAGGCACCCCGGCTTGGCGCTGTCTCTCCCCCTCGGCTC GGAGAGGCCCTTCGGCCTGAGGGAGCCTCGCCGCCCGTCCCCGGCACACGCGCAGCCCCG GCCTCTCGGCCTCTGCCGGAGAAACAGTTGGGACCCCTGATTTTAGCAGGATGGCCCAAT GGAATCAGCTACAGCAGCTTGACACACGGTACCTGGAGCAGCTCCATCAGCTCTACAGTG ACAGCTTCCCAATGGAGCTGCGGCAGTTTCTGGCCCCTTGGATTGAGAGTCAAGATTGGG CATATGCGGCCAGCAAAGAATCACATGCCACTTTGGTGTTTCATAATCTCCTGGGAGAGA TTGACCAGCAGTATAGCCGCTTCCTGCAAGAGTCGAATGTTCTCTATCAGCACAATCTAC GAAGAATCAAGCAGTTTCTTCAGAGCAGGTATCTTGAGAAGCCAATGGAGATTGCCCGGA TTGTGGCCCGGTGCCTGTGGGAAGAATCACGCCTTCTACAGACTGCAGCCACTGCGGCCC AGCAAGGGGGCCAGGCCAACCACCCCACAGCAGCCGTGGTGACGGAGAAGCAGCAGATGC TGGAGCAGCACCTTCAGGATGTCCGGAAGAGAGTGCAGGATCTAGAACAAAAATGAAAGT GGTAGAGAATCTCCAGGATGACTTTGATTTCAACTATAAAACCCTTAAGAGTCAAGGAGA CATGCCAGATCTGAATGCCAACAACCAGTCAGTGACCCCGCACCAAGATGCAGCAGCTGT AACAGATGCTCACTGCGCTCGACAGAATGCGAGAAACATCGTGAGTGAACTGCCGGGCCT TTGTCAGCGAGTGAGCCCCGCCAA >OriGene 3' read for NM_139276 unedited
CGATGATGCACCTTCCGGGCCGGAGAGGCACTGGGGAGGGGTCACAGGGATGCCACCCGG GATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTGAAACAGAATCTCAAACTGTCGCCCAGGATGGAGTGCAGTGT GCAGTGGTGCAATTTTGGCTCACTGCAACCTCCGCCTCTCAGGTTCAAGCGATTCTCCTG CCTCAGCCTCCCGAGTAGCTGGGACTACAGGCCCCCACCACCCCACCCCGCTAATTTTTT GTACTTTTAGTAAAGACGGGGTTTCACCGTGTTAGCCCGGATGGTCTTGATCTCCTGACC TTATGATCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCGG CTGCTTAAGTTTCTTAAATACCGAAAGGCTATGCTGATACCGTGTTTTTTGCCCTTTAAT TGTTATTATTTCTTAATTTAAAAAGAAACCTAGGGCTTAAATAGTCCTATCTTCTATTTT GATGTCAGCCAGGTTAAAAAGTGCAATGCCCGGAGTATGTAGCTATAGGTGGGCTGTGGC ATTTGCTTACAAAAAACAGGCAAAAGATGCCGCACGCACCAAGAAGCACTTGTCTAAAAA CAACAACAACAATAACAAAAAGCCTCTGAAAAAAGAGGGGCAGGGGAACAAAACACCAAC AAAAATTTTTCTTTTTTCTTCCTTCTTACCCCCCCCACGCCACATCCCCTGGATTTCGGG GTCTCAAAAGAAAACATTCCTTATTTTGCTTTTAGATAAAAGACAATCACACACATTTAC TCAATTCTCCATTTTAAAAATGCCTTAGTGCCTCCCGATATTCCAATTTGGATAATAAAC AAATTCTGCCACCCCAATTTCGTGCTCTCAAAATATCTGGGTTTCGCCCTTTTGAAGGGT C |
| Restriction Sites | NotI-NotI |
| ACCN | NM_139276 |
| Insert Size | 3384 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_139276.2, NP_644805.1 |
| RefSeq Size | 4978 bp |
| RefSeq ORF | 2313 bp |
| Locus ID | 6774 |
| UniProt ID | P40763 |
| Domains | SH2, STAT |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Acute myeloid leukemia, Adipocytokine signaling pathway, Chemokine signaling pathway, Jak-STAT signaling pathway, Pancreatic cancer, Pathways in cancer |
| Gene Summary | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020] Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (1). |
Citations (11)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Suppression of autophagy facilitates hydrogen gas-mediated lung cancer cell apoptosis
,Liu, L;Yan, Z;Wang, Y;Meng, J;Chen, G;,
Oncol Lett
,PubMed ID 32863925
[STAT3]
|
|
A Novel STAT3 Mutation in a Qatari Patient With Hyper-IgE Syndrome
,null,
Frontiers in Pediatrics
,PubMed ID 31069200
[STAT3]
|
|
STAT3-induced WDR1 overexpression promotes breast cancer cell migration
,Lee, JH;Kim, JE;Kim, BG;Han, HH;Kang, S;Cho, NH;,
Cell. Signal.
,PubMed ID 27521604
[STAT3]
|
|
At High Levels, Constitutively Activated STAT3 Induces Apoptosis of Chronic Lymphocytic Leukemia Cells
,Rozovski, U;Harris, DM;Li, P;Liu, Z;Wu, JY;Grgurevic, S;Faderl, S;Ferrajoli, A;Wierda, WG;Martinez, M;Verstovsek, S;Keating, MJ;Estrov, Z;,
J. Immunol.
,PubMed ID 27076684
[STAT3]
|
|
Modulation of vascular smooth muscle cell phenotype by STAT-1 and STAT-3
,Kirchmer, MN;Franco, A;Albasanz-Puig, A;Murray, J;Yagi, M;Gao, L;Dong, ZM;Wijelath, ES;,
Atherosclerosis
,PubMed ID 24657387
[STAT3]
|
|
MafB is a downstream target of the IL-10/STAT3 signaling pathway, involved in the regulation of macrophage de-activation
,Gemelli, C;Marani, TZ;Bicciato, S;Mazza, EM;Boraschi, D;Salsi, V;Zappavigna, V;Parenti, S;Selmi, T;Tagliafico, E;Ferrari, S;Grande, A;,
Biochim. Biophys. Acta, Feb 2014.
,PubMed ID 24472656
[STAT3]
|
|
Hepatitis C Virus Induced Changes in miRNA-107 and miRNA-449a Modulate CCL2 by Targeting IL6 Receptor Complex in Hepatitis
,Sarma, NJ;Tiriveedhi, V;Crippin, JS;Chapman, WC;Mohanakumar, T;,
J. Virol., Jan 2014.
,PubMed ID 24429361
[STAT3]
|
|
Intronic microRNA suppresses endothelial nitric oxide synthase expression and endothelial cell proliferation via inhibition of STAT3 signaling.
,null,
Molecular and cellular biochemistry
,PubMed ID 21611796
[STAT3]
|
|
Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas
,null,
The Journal of Experimental Medicine
,PubMed ID 21690253
[STAT3]
|
|
S-Glutathionylation Impairs Signal Transducer and Activator of Transcription 3 Activation and Signaling
,Yi Xie, Sutapa Kole, Patricia Precht, Michael J. Pazin, and Michel Bernier,
Endocrinology, Mar 2009; 150: 1122 - 1131.
[STAT3]
|
|
The Proinflammatory Cytokine, Interleukin-6, Up-regulates Calcium-sensing Receptor Gene Transcription via Stat1/3 and Sp1/3
,Lucie Canaff, Xiang Zhou, and Geoffrey N. Hendy,
J. Biol. Chem., May 2008; 283: 13586 - 13600
[STAT3]
|
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC215836 | STAT3 (Myc-DDK-tagged)-Human signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1 |
CNY 8,456.00 |
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| RC215836L1 | Lenti ORF clone of Human signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1, Myc-DDK-tagged |
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| RC215836L2 | Lenti ORF clone of Human signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1, mGFP tagged |
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| RC215836L3 | Lenti ORF clone of Human signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1, Myc-DDK-tagged |
CNY 10,856.00 |
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| RC215836L4 | Lenti ORF clone of Human signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1, mGFP tagged |
CNY 10,856.00 |
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| RG215836 | STAT3 (tGFP-tagged) - Human signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1 |
CNY 10,056.00 |
