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IL2 (NM_000586) Human Untagged Clone
CAT＃: SC125234
IL2 (untagged)-Human interleukin 2 (IL2)
CNY 1,200.00
CNY 3,990.00
| Cited in 3 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | IL-2; lymphokine; TCGF |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC125234 sequence for NM_000586 edited (data generated by NextGen Sequencing)
ATGTACAGGATGCAACTCCTGTCTTGCATTGCACTAAGTCTTGCACTTGTCACAAACAGT GCACCTACTTCAAGTTCTACAAAGAAAACACAGCTACAACTGGAGCATTTACTTCTGGAT TTACAGATGATTTTGAATGGAATTAATAATTACAAGAATCCCAAACTCACCAGGATGCTC ACATTTAAGTTTTACATGCCCAAGAAGGCCACAGAACTGAAACATCTTCAGTGTCTAGAA GAAGAACTCAAACCTCTGGAGGAAGTGCTAAATTTAGCTCAAAGCAAAAACTTTCACTTA AGACCCAGGGACTTAATCAGCAATATCAACGTAATAGTTCTGGAACTAAAGGGATCTGAA ACAACATTCATGTGTGAATATGCTGATGAGACAGCAACCATTGTAGAATTTCTGAACAGA TGGATTACCTTTTGTCAAAGCATCATCTCAACACTGACTTGA Clone variation with respect to NM_000586.3 114 g=>t >OriGene 5' read for NM_000586 unedited
GACTCACTATAGGGCGGCCGCGAATTCCCTGCCACAATGTACAGGATGCAACTCCTGTCT TGCATTGCACTAAGTCTTGCACTTGTCACAAACAGTGCACCTACTTCAAGTTCTACAAAG AAAACACAGCTACAACTGGAGCATTTACTTCTGGATTTACAGATGATTTTGAATGGAATT AATAATTACAAGAATCCCAAACTCACCAGGATGCTCACATTTAAGTTTTACATGCCCAAG AAGGCCACAGAACTGAAACATCTTCAGTGTCTAGAAGAAGAACTCAAACCTCTGGAGGAA GTGCTAAATTTAGCTCAAAGCAAAAACTTTCACTTAAGACCCAGGGACTTAATCAGCAAT ATCAACGTAATAGTTCTGGAACTAAAGGGATCTGAAACAACATTCATGTGTGAATATGCT GATGAGACAGCAACCATTGTAGAATTTCTGAACAGATGGATTACCTTTTGTCAAAGCATC ATCTCAACACTGACTTGATAATTAAGTGCTTCCCACTTAAAACATATCAGGCCTCGACTC TAGATTGCGGCCGCGGTCATANGCTGTTCCTGAACAGATTCCGGGTGGGATCCTTGTGAC CCTTCCCATGGCGCTTTCGGGCCCGGAGTAGTCCTACTCAGGGCACACAACTTGGCCATA AAAATAAATGGCACAATTTGTCCGCGAGAGGGGCCTCTAAAATATAGGGGGGGGGGGGGG GGGGGGGGGGGCGCTTGGAAACACCGGTGGGCCG >OriGene 3' read for NM_000586 unedited
ACCCATGGATCCTGGGCTGATGGCACTTNCCAGGNCCAGNAAAGCACTGGGGNAGGGTCA CAGGGCATGCCACCCGGGTTCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAG TCGAGGCCTGATATGTTTTAAGTGGGAAGCACTTAATTATCAAGTCAGTGTTGAGATGAT GCTTTGACAAAAGGTAATCCATCTGTTCAGAAATTCTACAATGGTTGCTGTCTCATCAGC ATATTCACACATGAATGTTGTTTCAGATCCCTTTAGTTCCAGAACTATTACGTTGATATT GCTGATTAAGTCCCTGGGTCTTAAGTGAAAGTTTTTGCTTTGAGCTAAATTTAGCACTTC CTCCAGAGGTTTGAGTTCTTCTTCTAGACACTGAAGATGTTTCAGTTCTGTGGCCTTCTT GGGCATGTAAAACTTAAATGTGAGCATCCTGGTGAGTTTGGGATTCTTGTAATTATTAAT TCCATTCAAAATCATCTGTAAATCCAGAAGTAAATGCTCCAGTTGTAGCTGTGTTTTCTT TGTAGAACTTGAAGTAGGTGCACTGTTTGTGACAAGTGCAAGACTTAGTGCAATGCAAGA CAGGAGTTGCATCCTGTACATTGTGGCAGGGAATTCGCGGCCGCCCTATAGTGAGTCGTA TTACANAATTCTGACGGTTCACTAAACGAGCTCTGCTTATATAGACCTCCCACCGTACAC GCCTACCGCCCATTTGCGTCAACGGNGCGGGGTTATTACGACATTTTGGAAAGTCCNGTT GATTTTGGGTGCAAAACANACTCCCATTGACGTCAATGGGGTGGAGACTTGGAAATCCCC GTGAGTCAAACCGCTATCCACGCCCATTGGTGTACTGGGCAAACCGCATCACCATGGTAA TAGCGATGACTATACGTAGATTACTGGCAT |
| Restriction Sites | Please inquire |
| ACCN | NM_000586 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000586.2, NP_000577.2 |
| RefSeq Size | 1047 bp |
| RefSeq ORF | 462 bp |
| Locus ID | 3558 |
| UniProt ID | P60568 |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | Allograft rejection, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, T cell receptor signaling pathway, Type I diabetes mellitus |
| Gene Summary | This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Sep 2020] |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Regulatory T cells control toxicity in a humanized model of IL-2 therapy
,Li, Y;Strick-Marchand, H;Lim, AI;Ren, J;Masse-Ranson, G;Dan Li, ;Jouvion, G;Rogge, L;Lucas, S;Bin Li, ;Di Santo, JP;,
Nat Commun
,PubMed ID 29176694
[IL2]
|
|
A functional DC cross talk promotes human ILC homeostasis in humanized mice
,Lopez-Lastra, S;Masse-Ranson, G;Fiquet, O;Darche, S;Serafini, N;Li, Y;Dusséaux, M;Strick-Marchand, H;Santo, JP;,
Blood Advances
[IL2]
|
|
MAC-T Cells as a Tool to Evaluate Lentiviral Vector Construction Targeting Recombinant Protein Expression in Milk
,Monzani, PS;Guemra, S;Adona, PR;Ohashi, OM;Meirelles, FV;Wheeler, MB;,
Anim. Biotechnol.
,PubMed ID 25380466
[IL2]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC210013 | IL2 (Myc-DDK-tagged)-Human interleukin 2 (IL2) |
CNY 1,200.00 |
|
| RC210013L1 | Lenti ORF clone of Human interleukin 2 (IL2), Myc-DDK-tagged |
CNY 3,600.00 |
|
| RC210013L2 | Lenti ORF clone of Human interleukin 2 (IL2), mGFP tagged |
CNY 5,890.00 |
|
| RC210013L3 | Lenti ORF clone of Human interleukin 2 (IL2), Myc-DDK-tagged |
CNY 3,600.00 |
|
| RC210013L4 | Lenti ORF clone of Human interleukin 2 (IL2), mGFP tagged |
CNY 3,600.00 |
|
| RG210013 | IL2 (tGFP-tagged) - Human interleukin 2 (IL2) |
CNY 2,800.00 |
