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SIRP alpha (SIRPA) (BC026692) Human Untagged Clone
CAT＃: SC125649
SIRPA (untagged)-Human protein tyrosine phosphatase, non-receptor type substrate 1, mRNA (cDNA clone MGC:9637 IMAGE:3916836), complete cds
CNY 3,776.00
货期*
现货
规格
Product images
经常一起买 (4)
SIRPA mouse monoclonal antibody, clone OTI7B3 (formerly 7B3)
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | BIT; brain-immunoglobulin-like molecule with tyrosine-based activation motifs; CD172A; macrophage fusion receptor; MFR; MYD-1; myd-1 antigen; OTTHUMP00000030001; P84; prote; PTPNS1; SHPS-1; SHPS1; SHP substrate-1; SIRP; SIRP-ALPHA-1; SIRPalpha; SIRPalpha2 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for BC026692 edited
CGCCGTGTGGAGCCCGGGCGGGGCAGCCGCGGCCCATGGAGCCCGCCGGCCCGGCCCCCG GCCGCCTCGGGCCGCTGCTCTGCCTGCTGCTCGCCGCGTCCTGCGCCTGGTCAGGAGTGG CGGGTGAGGAGGAGCTGCAGGTGATTCAGCCTGACAAGTCCGTATCAGTTGCAGCTGGAG AGTCGGCCATTCTGCACTGCACTGTGACCTCCCTGATCCCTGTGGGGCCCATCCAGTGGT TCAGAGGAGCTGGACCAGCCCGGGAATTAATCTACAATCAAAAAGAAGGCCACTTCCCCC GGGTAACAACTGTTTCAGAGTCCACAAAGAGAGAAAACATGGACTTTTCCATCAGCATCA GTAACATCACCCCAGCAGATGCCGGCACCTACTACTGTGTGAAGTTCCGGAAAGGGAGCC CTGACACGGAGTTTAAGTCTGGAGCAGGCACTGAGCTGTCTGTGCGTGCCAAACCCTCTG CCCCCGTGGTATCGGGCCCTGCGGCGAGGGCCACACCTCAGCACACAGTGAGCTTCACCT GCGAGTCCCACGGCTTCTCACCCAGAGACATCACCCTGAAATGGTTCAAAAATGGGAATG AGCTCTCAGACTTCCAGACCAACGTGGACCCCGTAGGAGAGAGCGTGTCCTACAGCATCC ACAGCACAGCCAAGGTGGTGCTGACCCGCGAGGACGTTCACTCTCAAGTCATCTGCGAGG TGGCCCACGTCACCTTGCAGGGGGACCCTCTTCGTGGGACTGCCAACTTGTCTGAGACCA TCCGAGTTCCACCCACCTTGGAGGTTACTCAACAGCCCGTGAGGGCAGAGAACCAGGTGA ATGTCACCTGCCAGGTGAGGAAGTTCTACCCCCAGAGACTACAGCTGACCTGGTTGGAGA ATGGAAACGTGTCCCGGACAGAAACGGCCTCAACCGTTACAGAGAACAAGGATGGTACCT ACAACTGGATGAGCTGGCTCCTGGTGAATGTATCTGCCCACAGGGATGATGTGAAGCTCA CCTGCCAGGTGGAGCATGACGGGCAGCCAGCGGTCAGCAAAAGCCATGACCTGAAGGTCT CAGCCCACCCGAAGGAGCAGGGCTCAAATACCGCCGCTGAGAACACTGGATCTAATGAAC GGAACATCTATATTGTGGTGGGTGTGGTGTGCACCTTGCTGGTGGCCCTACTGATGGCGG CCCTCTACCTCGTCCGAATCAGACAGAAGAAAGCCCAGGGCTCCACTTCTTCTACAAGGT TGCATGAGCCCGAGAAGAATGCCAGAGAAATAACACAGGTACAGTCCTTGGACACAAATG ATATCACATATGCAGACCTGAACCTGCCCAAGGGGAAGAAGCCTGCTCCCCAGGCTGCGG AGCCCAACAACCACACGGAGTATGCCAGCATTCAGACCAGCCCGCAGCCCGCGTCGGAGG ACACCCTCACCTATGCTGACCTGGACATGGTCCACCTCAACCGGACCCCCAAGCAGCCGG CCCCCAAGCCTGAGCCGTCCTTCTCAGAGTACGCCAGCGTCCAGGTCCCGAGGAAGTGAA TGGGACCGTGGTTTGCTCTAGCACCCATCTCTACGCGCTTTCTTGTCCCACAGGGAGCCG CCGTGATGAGCACAGCCAACCCAGTTCCCGGAGGGCTGGGGCGGTGCAGGCTCTGGGACC CAGGGGCCAGGGTGGCTCTTCTCTCCCCACCCCTCCTTGGCTCTCCAGCACTTCCTGGGC AGCCACGGCCCCCTCCCCCCACATTGCCACATACCTGGAGGCTGACGTTGCCAAACCAGC CAGGGAACCAACCTGGGAAGTGGCCAGAACTGCCTGGGGTCCAAGAACTCTTGTGCCTCC GTCCATCACCATGTGGGTTTTGAAGACCCTCGACTGCCTCCCCGATGCTCCGAAGCCTGA TCTTCCAGGGTGGGGAGGAGAAAATCCCACCTCCCCTGACCTCCACCACCTCCACCACCA CCACCACCACCACCACCACCACTACCACCACCACCCAACTGGGGCTAGAGTGGGGAAGAT TTCCCCTTTAGATCAAACTGCCCCTTCCATGGAAAAGCTGGAAAAAAACTCTGGAACCCA TATCCAGGCTTGGTGAGGTTGCTGCCAACAGTCCTGGCCTCCCCCATCCCTAGGCTAAAG AGCCATGAGTCCTGGAGGAGGAGAGGACCCCTCCCAAAGGACTGGAGACAAAACCCTCTG CTTCCTTGGGTCCCTCCAAGACTCCCTGGGGCCCAACTGTGTTGCTCCACCCGGACCCAT CTCTCCCTTCTAGACCTGAGCTTGCCCCTCCAGCTAGCACTAAGCAACATCTCGCTGTGG ACGCCTGTAAATTACTGAGAAATGTGAAACGTGCAATCTTGAAACTGAGGTGTTAGAAAA CTTGATCTGTGGTGTTTTGTTTTGTTTTTTTTCTTAAAACAACAGCAACGTGATCTTGGC TGTCTGTCATGTGTTGAAGTCCATGGTTGGGTCTTGTGAAGTCTGAGGTTTAACAGTTTG TTGTCCTGGAGGGATTTTCTTACAGCGAAGACTTGAGTTCCTCCAAGTCCCAGAACCCCA AGAATGGGCAAGAAGGATCAGGTCAGCCACTCCCTGGAGACACAGCCTTCTGGCTGGGAC TGACTTGGCCATGTTCTCAGCTGAGCCACGCGGCTGGTAGTGCAGCCTTCTGTGACCCCG CTGTGGTAAGTCCAGCCTGCCCAGGGCTGCTGAGGGCTGCCTCTTGACAGTGCAGTCTTA TCGAGACCCAACGCCTCAGCCTGCTCATCCGTAAAGTGGGGATAGTGAAGATGACACCCC TCCCCACCACCTCTCATAAGCACTTTAGGAACACACAGAGGGTAGGGATAGTGGCCCTGG CCGTCTATCCTACCCCTTTAGTGACCGCCCCCATCCCGGCTTTCTGAGCTGATCCTTGAA GAAGAAATCTTCCATTTCTGCTCTCAAACCCTACTGGGATCAAACTGGAATAAATTGAAG ACAGCCAGGGGGATGGTGCAGCTGTGAAGCTCGGGCTGATTCCCCCTCTGTCCCAGAAGG TTGGCCAGAGGGTGTGACCCAGTTACCCTTTAACCCCCACCCTTCCAGTCGGGTGTGAGG GCCTGACCGGGCCCAGGGCAAGCAGATGTCGCAAGCCCTATTTATTCAGTCTTCACTATA ACTCTTAGAGTTGAGACGCTAATGTTCATGACTCCTGGCCTTGGGATGCCCAAGGGATTT CTGGCTCAGGCTGTAAAAGTAGCTGAGCCATCCTGCCCATTCCTGGAGGTCCTACAGGTG AAACTGCAGGAGCTCAGCATAGACCCAGCTCTCTGGGGGATGGTCACCTGGTGATTTCAA TGATGGCATCCAGGAATTAGCTGAGCCAACAGACCATGTGGACAGCTTTGGCCAGAGCTC CCGTGTGGCATCTGGGAGCCACAGTGACCCAGCCACCTGGCTCAGGCTAGTTCCAAATTC CAAAAGATTGGCTTGTAAACCTTCGTCTCCCTCTCTTTTACCCAGAGACAGCACATACGT GTGCACACGCATGCACACACACATTCAGTATTTTAAAAGAATGTTTTCTTGGTGCCATTT TCATTTTATTTTATTTTTTAATTCTTGGAGGGGGAAATAAGGGAATAAGGCCAAGGAAGA TGTATAGCTTTAGCTTTAGCCTGGCAACCTGGAGAATCCACATACCTTGTGTATTGAACC CCAGGAAAAGGAAGAGGTCGAACCAACCCTGCGGAAGGAGCATGGTTTCAGGAGTTTATT TTAAGACTGCTGGGAAGGAAACAGGCCCCATTTTGTATATAGTTGCAACTTAAACTTTTT GGCTTGCAAAATATTTTTGTAATAAAGATTTCTGGGTAATAATGAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAA >OriGene 5' read for BC026692 unedited
TACAGTTCGGATTTGTATACGACTCATATAGGCGGCCGCGTATTCCCGGGGTATCGTCGA CCCACGCGTCCGCGCCGTGTGGAGCCCGGGCGGGGCAGCCGCGGCCCATGGAGCCCGCCG GCCCGGCCCCCGGCCGCCTCGGGCCGCTGCTCTGCCTGCTGCTCGCCGCGTCCTGCGCCT GGTCAGGAGTGGCGGGTGAGGAGGAGCTGCAGGTGATTCAGCCTGACAAGTCCGTATCAG TTGCAGCTGGAGAGTCGGCCATTCTGCACTGCACTGTGACCTCCCTGATCCCTGTGGGGC CCATCCAGTGGTTCAGAGGAGCTGGACCAGCCCGGGAATTAATCTACAATCAAAAAGAAG GCCACTTCCCCCGGGTAACAACTGTTTCAGAGTCCACAAAGAGAGAAAACATGGACTTTT CCATCAGCATCAGTAACATCACCCCAGCAGATGCCGGCACCTACTACTGTGTGAAGTTCC GGAAAGGGAGCCCTGACACGGAGTTTAAGTCTGGAGCAGGCACTGAGCTGTCTGTGCGTG CCAAACCCTCTGCCCCCGTGGTATCGGGCCCTGCGGCGAGGGCCACACCTCAGCACACAG TGAGCTTCACCTGCGAGTCCCACGGCTTCTCACCCAGAGACATCACCCTGAAATGGTTCA AAAATGGGAATGAGCTCTCAGACTTCCAGACCAACGTGGACCCCGTAGGAGAGAGCGTGT CCTACAGCATCCACAGCACAGCCAAGGTGGTGCTGACCCGCGAGGACGTTCACTCTCAAG TCATCTGCGAGGTGGCCCACGTCACCTTGCAGGGGGACCCTCTTCGTGGGACTGCCCACT TGTCTGAGACCCTCCGAGTTCCACCCACCTTGGAGTTACTCACCGCCCCTGAGGGCAGAA AAACAG |
| Restriction Sites | NotI-NotI |
| ACCN | BC026692 |
| Insert Size | 3900 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC026692.1, AAH26692.1 |
| RefSeq Size | 3921 bp |
| RefSeq ORF | 1521 bp |
| Locus ID | 140885 |
| Protein Families | Druggable Genome, Phosphatase, Transmembrane |
| Gene Summary | The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008] |
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