PGPEP1 (BC042138) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	5-oxoprolyl-peptidase; FLJ20208; MGC10812; Pcp; PGP; PGP-I; PGPI; pyroglutamyl-peptidase I; pyrrolidone-carboxylate peptidase
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC042138 edited GAGGCTGCAGCGGCAGCAGCTGTCGCGCCAGTCGCAACAGAAGCAGGTCCGAGGCACAGC CCGATCCCGCCATGGAGCAGCCGAGGAAGGCGGTGGTAGTGACGGGATTTGGCCCTTTTG GGGAACACACCGTGAACGCCAGTTGGATTGCAGTTCAGAGATGGGATCTCACTATATTGC CCTGGCTGGTCTTGAACTTCCGGGCTCAAATGATCCTTCCACCTCGGCCTCCCAAAGAAG CTGGGATTATAGGTGTGAGCCACCGAGCCCTGCCATCAGGAGCTAGAAAAGCTAGGCCTT GGCGACAGCGTGGACCTGCATGTGTACGAGATTCCGGTTGAGTACCAAACAGTCCAGAGA CTCATCCCCGCCCTGTGGGAGAAGCACAGTCCACAGCTGGTGGTGCATGTGGGGGTGTCA GGCATGGCGACCACAGTCACACTGGAGAAATGTGGACACAACAAGGGCTACAAGGGGCTG GACAACTGCCGCTTTTGCCCCGGCTCCCAGTGCTGCGTGGAGGACGGGCCTGAAAGCATT GACTCCATCATCGACATGGATGCTGTGTGCAAGCGAGTCACCACGTTGGGCCTGGATGTG TCGGTGACCATCTCGCAGGATGCCGGCAGATATCTCTGCGACTTTACCTACTACACCTCT TTGTACCAGAGTCACGGTCGATCAGCCTTCGTCCACGTGCCCCCACTGGGGAAGCCGTAC AACGCGGACCAGCTGGGCAGGGCACTGAGAGCCATCATTGAGGAGATGTTGGACCTCCTG GAGCAGTCAGAGGGCAAAATCAACTATTGCCACAAACACTGAGGGACGCTCAGGTCTCCT AAGACCTCATCCTGCTGGGGACCCCACGAGGGGACATCCACCCTCTGGGGTGTGGCCAGG AAAAGACAAGCTCTTCAGCTTGGGGATCCGATCTGGAAGAGAGATTCTGATCTGCCCACC TCCTCTTCCTCCTTCTCTACAAAAGCTCCGGTTGATTCGAGGGAAGTGGTGAAAAATTTT TTTTCTCCCATTTTCCTCCCTGCATCTGGGGACACAGCTGCCGTGACCAGGGAGGCCAGC CTGGGAGGTCCAGATGCCCAGGGAGAATCTTGGTCTGGTGAATCCATGAGCTGCGATACC ACGGCTGGGGCCATATGTTCACCTGCTTTCCTGTCCGTTGGTGAAGGAATTTCAGAATTC ATTTTATATCCAAGACTGGCTTTTACCAAATTTAAAAAAAAAAAAAAAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC042138 unedited CCCCGCAGTCAGGATTTGTATACGACTTATATAGGGCGGCCGCGAATTCGCACGAGGGAG GCTGCAGCGGCAGCAGCTGTCGCGCCAGTCGCAACAGAAGCAGGTCCGAGGCACAGCCCG ATCCCGCCATGGAGCAGCCGAGGAAGGCGGTGGTAGTGACGGGATTTGGCCCTTTTGGGG AACACACCGTGAACGCCAGTTGGATTGCAGTTCAGAGATGGGATCTCACTATATTGCCCT GGCTGGTCTTGAACTTCCGGGCTCAAATGATCCTTCCACCTCGGCCTCCCAAAGAAGCTG GGATTATAGGTGTGAGCCACCGAGCCCTGCCATCAGGAGCTAGAAAAGCTAGGCCTTGGC GACAGCGTGGACCTGCATGTGTACGAGATTCCGGTTGAGTACCAAACAGTCCAGAGACTC ATCCCCGCCCTGTGGGAGAAGCACAGTCCACAGCTGGTGGTGCATGTGGGGGTGTCAGGC ATGGCGACCACAGTCACACTGGAGAAATGTGGACACAACAAGGGCTACAAGGGGCTGGAC AACTGCCGCTTTTGCCCCGGCTCCCAGTGCTGCGTGGAGGACGGGCCTGAAAGCATTGAC TCCATCATCGACATGGATGCTGTGTGCAAGCGAGTCACCACGTTGGGCCTGGATGTGTCG GTGACCATCTCGCAGGATGCCGGCAGATATCTCTGCGACTTTACCTACTACACCTCTTTG TACCAGAGTCACGGTCGATCAGCCTTCGTCCACGTGCCCCCACTGGGGAAGCCGTACAAC GCGGACCAGCTGGGCAGGGCACTGAGAGCCATCATTGAGGAGATGTTGGACTCCTGGAGC AGTCAGAGGGCAAATCACTATTGCCACAAAACTGAGGGAC
Restriction Sites	Please inquire
ACCN	BC042138
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC042138.1, AAH42138.1
RefSeq Size	1251 bp
Locus ID	54858
Protein Families	Druggable Genome, Protease
Gene Summary	The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]

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