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KAT2A (NM_021078) Human Untagged Clone
CAT＃: SC125929
KAT2A (untagged)-Human K(lysine) acetyltransferase 2A (KAT2A)
CNY 9,208.00
| Cited in 1 publication. |
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热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | GCN5; GCN5L2; hGCN5; PCAF-b |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_021078 edited
CCACGCGTCCGGGGCTGGGAGCGCGGCGCCGCTCTCCGCTGCGGGGGAGGCCATGGCGGA ACCTTCCCAGGCCCCGACCCCGGCCCCGGCTGCGCAGCCCCGGCCCCTTCAGTCCCCAGC CCCTGCCCCAACTCCGACTCCTGCACCCAGCCCGGCTTCAGCCCCGATTCCGACTCCCAC CCCGGCACCAGCCCCTGCCCCAGCTGCAGCCCCAGCCGGCAGCACAGGGACTGGGGGGCC CGGGGTAGGAAGTGGGGGGGCCGGGAGCGGGGGGGATCCGGCTCGACCTGGCCTGAGCCA GCAGCAGCGCGCCAGTCAGAGGAAGGCGCAAGTCCGGGGGCTGCCGCGCGCCAAGAAGCT TGAGAAGCTAGGGGTCTTCTCGGCTTGCAAGGCCAATGAAACCTGTAAGTGTAATGGCTG GAAAAACCCCAAGCCCCCCACTGCACCCCGCATGGATCTGCAGCAGCCAGCTGCCAACCT GAGTGAGCTGTGCCGCAGTTGTGAGCACCCCTTGGCTGACCACGTATCCCACTTGGAGAA TGTGTCAGAGGATGAGATAAACCGACTGCTGGGGATGGTGGTGGATGTGGAGAATCTCTT CATGTCTGTTCACAAGGAAGAGGACACAGACACCAAGCAGGTCTATTTCTACCTCTTCAA GCTACTGCGGAAATGCATCCTGCAGATGACCCGGCCTGTGGTGGAGGGGTCCCTGGGCAG CCCTCCATTTGAGAAACCTAATATTGAGCAGGGTGTGCTGAACTTTGTGCAGTACAAGTT TAGTCACCTGGCTCCCCGGGAGCGGCAGACGATGTTCGAGCTCTCAAAGATGTTCTTGCT CTGCCTTAACTACTGGAAGCTTGAGACACCTGCCCAGTTTCGGCAGAGGTCTCAGGCTGA GGACGTGGCTACCTACAAGGTCAATTACACCAGATGGCTCTGTTACTGCCACGTGCCCCA GAGCTGTGATAGCCTCCCCCGCTACGAAACCACTCATGTCTTTGGGCGAAGCCTTCTCCG GTCCATTTTCACCGTTACCCGCCGGCAGCTGCTGGAAAAGTTCCGAGTGGAGAAGGACAA ATTGGTGCCCGAGAAGAGGACCCTCATCCTCACTCACTTCCCCAAATTCCTGTCCATGCT GGAGGAGGAGATCTATGGGGCAAACTCTCCAATCTGGGAGTCAGGCTTCACCATGCCACC CTCAGAGGGGACACAGCTGGTTCCCCGGCCAGCTTCAGTCAGTGCAGCGGTTGTTCCCAG CACCCCCATCTTCAGCCCCAGCATGGGTGGGGGCAGCAACAGCTCCCTGAGTCTGGATTC TGCAGGGGCCGAGCCTATGCCAGGCGAGAAGAGGACGCTCCCAGAGAACCTGACCCTGGA GGATGCCAAGCGGCTCCGTGTGATGGGTGACATCCCCATGGAGCTGGTCAATGAGGTCAT GCTGACCATCACTGACCCTGCTGCCATGCTGGGGCCTGAGACGAGCCTGCTTTCGGCCAA TGCGGCCCGGGATGAGACAGCCCGCCTGGAGGAGCGCCGCGGCATCATCGAGTTCCATGT CATCGGCAACTCACTGACGCCCAAGGCCAACCGGCGGGTGTTGCTGTGGCTCGTGGGGCT GCAGAATGTCTTTTCCCACCAGCTGCCGCGCATGCCTAAGGAGTATATCGCCCGCCTCGT CTTTGACCCGAAGCACAAGACTCTGGCCTTGATCAAGGATGGGCGGGTCATCGGTGGCAT CTGCTTCCGCATGTTTCCCACCCAGGGCTTCACGGAGATTGTCTTCTGTGCTGTCACCTC GAATGAGCAGGTCAAGGGTTATGGGACCCACCTGATGAACCACCTGAAGGAGTATCACAT CAAGCACAACATTCTCTACTTCCTCACCTACGCCGACGAGTACGCCATCGGCTACTTCAA AAAGCAGGGTTTCTCCAAGGACATCAAGGTGCCCAAGAGCCGCTACCTGGGCTACATCAA GGACTACGAGGGAGCGACGCTGATGGAGTGTGAGCTGAATCCCCGCATCCCCTACACGGA GCTGTCCCACATCATCAAGAAGCAGAAAGAGATCATCAAGAAGCTGATTGAGCGCAAACA GGCCCAGATCCGCAAGGTCTACCCGGGGCTCAGCTGCTTCAAGGAGGGCGTGAGGCAGAT CCCTGTGGAGAGCGTTCCTGGCATTCGAGAGACAGGCTGGAAGCCATTGGGGAAGGAGAA GGGGAAGGAGCTGAAGGACCCCGACCAGCTCTACACAACCCTCAAAAACCTGCTGGCCCA AATCAAGTCTCACCCCAGTGCCTGGCCCTTCATGGAGCCTGTGAAGAAGTCGGAGGCCCC TGACTACTACGAGGTCATCCGCTTCCCCATTGACCTGAAGACCATGACTGAGCGGCTGCG AAGCCGCTACTACGTGACCCGGAAGCTCTTTGTGGCCGACCTGCAGCGGGTCATCGCCAA CTGTCGCGAGTACAACCCCCCGGACAGCGAGTACTGCCGCTGTGCCAGCGCCCTGGAGAA GTTCTTCTACTTCAAGCTCAAGGAGGGAGGCCTCATTGACAAGTAGGCCCATCTTTGGGC CGCAGCCCTGACCTGGAATGTCTCCACCTCGGATTCTGATCTGATCCTTAGGGGGTGCCC TGGCCCCACGGACCCGACTCAGCTTGAGACACTCCAGCCAAGGGTCCTCCGGACCCGATC CTGCAGCTCTTTCTGGACCTTCAGGCACCCCCAAGCGTGCAGCTCTGTCCCAGCCTTCAC TGTGTGTGAGAGGTCTCCTGGGTTGGGGCCCAGCCCCTCTAGAGTAGCTGGTGGCCAGGG ATGAACCTTGCCCAGCCGTGGTGGCCCCCAGGCCTGGTCCCCAAGAGCTTTGGAGGCTTG GATTCCTGGGCCTGGCCCAGGTGGCTGTTTCCCTGAGGACCAGAACTGCTCATTTTAGCT TGAGTGATGGCTTCAGGGGTTGGAAGTTCAGCCCAAACTGAAGGGGGCCATGCCTTGTCC AGCACTGTTCTGTCAGTCTCCCCCAGGGGTGGGGGGTATGGGGACCATTCATTCCCTGGC ATTAATCCCTTAGAGGGAATAATAAAGCTTTTTATTTCTCTGTGAAAAAAAAAAAAAAA >OriGene 5' read for NM_021078 unedited
GGTTAGGATTTGTATACGACTTACTATAGGCGGCCGCGGATTCAGATCTGGTACCGGTCC GGAATTCCCGGGATATCGTCGACCCACGCGTCCGGGGCTGGGAGCGCGGCGCCGCTCTCC GCTGCGGGGGAGGCCATGGCGGAACCTTCCCAGGCCCCGACCCCGGCCCCGGCTGCGCAG CCCCGGCCCCTTCAGTCCCCAGCCCCTGCCCCAACTCCGACTCCTGCACCCAGCCCGGCT TCAGCCCCGATTCCGACTCCCACCCCGGCACCAGCCCCTGCCCCAGCTGCAGCCCCAGCC GGCAGCACAGGGACTGGGGGGCCCGGGGTAGGAAGTGGGGGGGCCGGGAGCGGGGGGGAT CCGGCTCGACCTGGCCTGAGCCAGCAGCAGCGCGCCAGTCAGAGGAAGGCGCAAGTCCGG GGGCTGCCGCGCGCCAAGAAGCTTGAGAAGCTAGGGGTCTTCTCGGCTTGCAAGGCCAAT GAAACCTGTAAGTGTAATGGCTGGAAAAACCCCAAGCCCCCCACTGCACCCCGCATGGAT CTGCAGCAGCCAGCTGCCAACCTGAGTGAGCTGTGCCGCAGTTGTGAGCACCCCTTGGCT GACCACGTATCCCACTTGGAGAATGTGTCAGAGGATGAGATAAACCGACTGCTGGGGATG GTGGTGGATGTGGAGAATCTCTTCATGTCTGTTCACAGGAAGAGGACACAGACACCAAGC AGGTCTATTTCTACCTCTTCAAGCTACTGCGGAAATGCATCCTGCAGATGACCCGGCCTG TGGTGGAGGGGTCCCTGGGCAGCCCTCCTTTTGAGAACCCAATATTGAGCAGGGTGTGCT GAACTTTGGGCCAGACAGGTTAGTCACCTGGCCTCCCGGAAGCGGCANACATGTTCCAGC CTCTAAAAAGTTCTTGCTCTGCCTA |
| Restriction Sites | Please inquire |
| ACCN | NM_021078 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_021078.1, NP_066564.1 |
| RefSeq Size | 3074 bp |
| RefSeq ORF | 2514 bp |
| Locus ID | 2648 |
| UniProt ID | Q92830 |
| Protein Families | Transcription Factors |
| Protein Pathways | Notch signaling pathway |
| Gene Summary | KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease
,Smith, MR;Syed, A;Lukacsovich, T;Purcell, J;Barbaro, BA;Worthge, SA;Wei, SR;Pollio, G;Magnoni, L;Scali, C;Massai, L;Franceschini, D;Camarri, M;Gianfriddo, M;Diodato, E;Thomas, R;Gokce, O;Tabrizi, SJ;Caricasole, A;Landwehrmeyer, B;Menalled, L;Murphy, C;Ramboz, S;Luthi-Carter, R;Westerberg, G;Marsh, JL;,
Hum. Mol. Genet., Jan 2014.
,PubMed ID 24436303
[KAT2A]
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Other Versions
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| RC207889L1 | Lenti-ORF clone of KAT2A (Myc-DDK-tagged)-Human K(lysine) acetyltransferase 2A (KAT2A) |
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| RC207889L2 | Lenti-ORF clone of KAT2A (mGFP-tagged)-Human K(lysine) acetyltransferase 2A (KAT2A) |
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| RC207889L3 | Lenti-ORF clone of KAT2A (Myc-DDK-tagged)-Human K(lysine) acetyltransferase 2A (KAT2A) |
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| RC207889L4 | Lenti-ORF clone of KAT2A (mGFP-tagged)-Human K(lysine) acetyltransferase 2A (KAT2A) |
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| RG207889 | KAT2A (tGFP-tagged) - Human K(lysine) acetyltransferase 2A (KAT2A) |
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