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GM2A (NM_000405) Human Untagged Clone
CAT＃: SC126904
GM2A (untagged)-Human GM2 ganglioside activator (GM2A), transcript variant 1
CNY 2,400.00
CNY 2,950.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | GM2-AP; SAP-3 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC126904 sequence for NM_000405 edited (data generated by NextGen Sequencing)
ATGCAGTCCCTGATGCAGGCTCCCCTCCTGATCGCCCTGGGCTTGCTTCTCGCGGCCCCT GCGCAAGCCCACCTGAAAAAGCCATCCCAGCTCAGTAGCTTTTCCTGGGATAACTGTGAT GAAGGGAAGGACCCTGCGGTGATCAGAAGCCTGACTCTGGAGCCTGACCCCATCATCGTT CCTGGAAATGTGACCCTCAGTGTCATGGGCAGCACCAGTGTCCCCCTGAGTTCTCCTCTG AAGGTGGATTTAGTTTTGGAGAAGGAGGTGGCTGGCCTCTGGATCAAGATCCCATGCACA GACTACATTGGCAGCTGTACCTTTGAACACTTCTGTGATGTGCTTGACATGTTAATTCCT ACTGGGGAGCCCTGCCCAGAGCCCCTGCGTACCTATGGGCTTCCTTGCCACTGTCCCTTC AAAGAAGGAACCTACTCACTGCCCAAGAGCGAATTCGTTGTGCCTGACCTGGAGCTGCCC AGTTGGCTCACCACCGGGAACTACCGCATAGAGAGCGTCCTGAGCAGCAGTGGGAAGCGT CTGGGCTGCATCAAGATCGCTGCCTCTCTAAAGGGCATATAA Clone variation with respect to NM_000405.4 >OriGene 5' read for NM_000405 unedited
NGCTTCAGGATTTTGTAATACGACTCACTATAGGGCGGCCGCGNAATTCGCACCAGCCGA TGCAGTCCCTGATGCAGGCTCCCCTCCTGATCGCCCTGGGCTTGCTTCTCGCGGCCCCTG CGCANAGCCCACCTGAAAAAGCCATCCCAGCTCAGTAGCTTTTCCTGGGATAACTGTGAT GAAGGGAAGGACCCTGCGGTGATCAGAAGCCTGACTCTGGAGCCTGACCCCATCATCGTT CCTGGAAATGTGACCCTCAGTGTCATGGGCAGCACCAGTGTCCCCCTGAGTTCTCCTCTG AAGGTGGATTTAGTTTTGGAGAAGGAGGTGGCTGGCCTCTGGATCAAGATCCCATGCACA GACTACATTGGCAGCTGTACCTTTGAACACTTCTGTGATGTGCTTGACATGTTAATTCCT ACTGGGGAGCCCTGCCCAGAGCCCCTGCGTACCTATGGGCTTCCTTGCCACTGTCCCTTC AAAGAAGGAACCTACTCACTGCCCAAGAGCGAATTCGTTGTGCCTGACCTGGAGCTGCCC AGTTGGCTCACCACCGGGAACTACCGCATAGAGAGCGTCCTGAGCAGCAGTGGGAAGCGT CTGGGCTGCATCAAGATCGCTGCCTCTCTAAAGGGCATATAACATGGCATCTGCCACAGC AGAATGGAGCGGTGTGAGGAAGGTCCCTTTTCCTCTGTTNTGTGTTTGCCAAGGCCAAAC TCCCACTCTCTGCCCCCCTTTAATCCCCTTTCTACAGTGAGTCCACTACCCTCACTGAAN ATCATTNTGTACCACTTACATTNTANGCTGGNGCAAGCAGCCCTGACCTAAGGGAGAATG AGTGGNACAGTTCTTGATAGCCCAGGGCATCTGCTGGGCTGACCACGTTACTCATCCCCG TTAACATTCTCTCTAAGAGCCTCGTTCATTTNCAG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000405 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000405.3, NP_000396.2 |
| RefSeq Size | 2521 bp |
| RefSeq ORF | 582 bp |
| Locus ID | 2760 |
| UniProt ID | P17900 |
| Domains | ML |
| Protein Families | Druggable Genome |
| Protein Pathways | Lysosome |
| Gene Summary | This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009] Transcript Variant: This variant (1) encodes the longer isoform (1). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity [S]
,null,
Journal of Lipid Research
,PubMed ID 26175473
[GM2A]
|
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Resources
Other Versions
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|---|---|---|---|
| RC202452 | GM2A (Myc-DDK-tagged)-Human GM2 ganglioside activator (GM2A), transcript variant 1 |
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| RC202452L1 | Lenti ORF clone of Human GM2 ganglioside activator (GM2A), transcript variant 1, Myc-DDK-tagged |
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| RC202452L2 | Lenti ORF clone of Human GM2 ganglioside activator (GM2A), transcript variant 1, mGFP tagged |
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| RC202452L3 | Lenti ORF clone of Human GM2 ganglioside activator (GM2A), transcript variant 1, Myc-DDK-tagged |
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| RC202452L4 | Lenti ORF clone of Human GM2 ganglioside activator (GM2A), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
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| RG202452 | GM2A (tGFP-tagged) - Human GM2 ganglioside activator (GM2A), transcript variant 1 |
CNY 4,000.00 |
