PTPN13 (NM_080683) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL; PTP1E; PTPL1; PTPLE
Vector	pCMV6-XL4
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for NM_080683, the custom clone sequence may differ by one or more nucleotides ATGCACGTGTCACTAGCTGAGGCCCTGGAGGTTCGGGGTGGACCACTTCAGGAGGAAGAAATATGGGCTG TATTAAATCAAAGTGCTGAAAGTCTCCAAGAATTATTCAGAAAAGTAAGCCTAGCTGATCCTGCTGCCCT TGGCTTCATCATTTCTCCATGGTCTCTGCTGTTGCTGCCATCTGGTAGTGTGTCATTTACAGATGAAAAT ATTTCCAATCAGGATCTTCGAGCATTCACTGCACCAGAGGTTCTTCAAAATCAGTCACTAACTTCTCTCT CAGATGTTGAAAAGATCCACATTTATTCTCTTGGAATGACACTGTATTGGGGGGCTGATTATGAAGTGCC TCAGAGCCAACCTATTAAGCTTGGAGATCATCTCAACAGCATACTGCTTGGAATGTGTGAGGATGTTATT TACGCTCGAGTTTCTGTTCGGACTGTGCTGGATGCTTGCAGTGCCCACATTAGGAATAGCAATTGTGCAC CCTCATTTTCCTACGTGAAACACTTGGTAAAACTGGTTCTGGGAAATCTTTCTGGGACAGATCAGCTTTC CTGTAACAGTGAACAAAAGCCTGATCGAAGCCAGGCTATTCGAGATCGATTGCGAGGAAAAGGATTACCA ACAGGAAGAAGCTCTACTTCTGATGTACTAGACATACAAAAGCCTCCACTCTCTCATCAGACCTTTCTTA ACAAAGGGCTTAGTAAATCTATGGGATTTCTGTCCATCAAAGATACACAAGATGAGAATTATTTCAAGGA CATTTTATCAGATAATTCTGGACGTGAAGATTCTGAAAATACATTCTCCCCTTACCAGTTCAAAACTAGT GGCCCAGAAAAAAAACCCATCCCTGGCATTGATGTGCTTTCTAAGAAGAAGATCTGGGCTTCATCCATGG ACTTGCTTTGTACAGCTGACAGAGACTTCTCTTCAGGAGAGACTGCCACATATCGTCGTTGTCACCCTGA GGCAGTAACAGTGCGGACTTCAACTACTCCTAGAAAAAAGGAGGCAAGATACTCAGATGGAAGTATAGCC TTGGATATCTTTGGCCCTCAGAAAATGGATCCAATATATCACACTCGAGAATTGCCCACCTCCTCAGCAA TATCAAGTGCTTTGGACCGAATCCGAGAGAGACAAAAGAAACTTCAGGTTCTGAGGGAAGCCATGAATGT AGAAGAACCAGTTCGAAGATACAAAACTTATCATGGTGATGTCTTTAGTACCTCCAGTGAAAGTCCATCT ATTATTTCCTCTGAATCAGATTTCAGACAAGTGAGAAGAAGTGAAGCCTCAAAGAGGTTTGAATCCAGCA GTGGTCTCCCAGGGGTAGATGAAACCTTAAGTCAAGGCCAGTCACAGAGACCGAGCAGACAATATGAAAC ACCCTTTGAAGGCAACTTAATTAATCAAGAGATCATGCTAAAACGGCAAGAGGAAGAACTGATGCAGCTA CAAGCCAAAATGGCCCTTAGACAGTCTCGGTTGAGCCTATATCCAGGAGACACAATCAAAGCGTCCATGC TTGACATCACCAGGGATCCGTTAAGAGAAATTGCCCTAGAAACAGCCATGACTCAAAGAAAACTGAGGAA TTTCTTTGGCCCTGAGTTTGTGAAAATGACAATTGAACCATTTATATCTTTGGATTTGCCACGGTCTATT CTTACTAAGAAAGGGAAGAATGAGGATAACCGAAGGAAAGTAAACATAATGCTTCTGAACGGGCAAAGAC TGGAACTGACCTGTGATACCAAAACTATATGTAAAGATGTGTTTGATATGGTTGTGGCACATATTGGCTT AGTAGAGCATCATTTGTTTGCTTTAGCTACCCTCAAAGATAATGAATATTTCTTTGTTGATCCTGACTTA AAATTAACCAAAGTGGCCCCAGAGGGATGGAAAGAAGAACCAAAGAAAAAGACCAAAGCCACTGTTAATT TTACTTTGTTTTTCAGAATTAAATTTTTTATGGATGATGTTAGTCTAATACAACATACTCTGACGTGTCA TCAGTATTACCTTCAGCTTCGAAAAGATATTTTGGAGGAAAGGATGCACTGTGATGATGAGACTTCCTTA TTGCTGGCATCCTTGGCTCTCCAGGCTGAGTATGGAGATTATCAACCAGAGGTTCATGGTGTGTCTTACT TTAGAATGGAGCACTATTTGCCCGCCAGAGTGATGGAGAAACTTGATTTATCCTATATCAAAGAAGAGTT ACCCAAATTGCATAATACCTATGTGGGAGCTTCTGAAAAAGAGACAGAGTTAGAATTTTTAAAGGTCTGC CAAAGACTGACAGAATATGGAGTTCATTTTCACCGAGTGCACCCTGAGAAGAAGTCACAAACAGGAATAT TGCTTGGAGTCTGTTCTAAAGGTGTCCTTGTGTTTGAAGTTCACAATGGAGTGCGCACATTGGTCCTTCG CTTTCCATGGAGGGAAACCAAGAAAATATCTTTTTCTAAAAAGAAAATCACATTGCAAAATACATCAGAT GGAATAAAACATGGCTTCCAGACAGACAACAGTAAGATATGCCAGTACCTGCTGCACCTCTGCTCTTACC AGCATAAGTTCCAGCTACAGATGAGAGCAAGACAGAGCAACCAAGATGCCCAAGATATTGAGAGAGCTTC GTTTAGGAGCCTGAATCTCCAAGCAGAGTCTGTTAGAGGATTTAATATGGGACGAGCAATCAGCACTGGC AGTCTGGCCAGCAGCACCCTCAACAAACTTGCTGTTCGACCTTTATCAGTTCAAGCTGAGATTCTGAAGA GGCTATCCTGCTCAGAGCTGTCGCTTTACCAGCCATTGCAAAACAGTTCAAAAGAGAAGAATGACAAAGC TTCATGGGAGGAAAAGCCTAGAGAGATGAGTAAATCATACCATGATCTCAGTCAGGCCTCTCTCTATCCA CATCGGAAAAATGTCATTGTTAACATGGAACCCCCACCACAAACCGTTGCAGAGTTGGTGGGAAAACCTT CTCACCAGATGTCAAGATCTGATGCAGAATCTTTGGCAGGAGTGACAAAACTTAATAATTCAAAGTCTGT TGCGAGTTTAAATAGAAGTCCTGAAAGGAGGAAACATGAATCAGACTCCTCATCCATTGAAGACCCTGGG CAAGCATATGTTCTAGGAATGACTATGCATAGTTCTGGAAACTCTTCATCCCAAGTACCCTTAAAAGAAA ATGATGTGCTACACAAAAGATGGAGCATAGTATCTTCACCAGAAAGGGAGATCACCTTAGTGAACCTGAA AAAAGATGCAAAGTATGGCTTGGGATTTCAAATTATTGGTGGGGAGAAGATGGGAAGACTGGACCTAGGC ATATTTATCAGTTCAGTTGCCCCTGGAGGACCAGCTGACTTGGATGGATGCTTGAAGCCAGGAGACCGTT TGATATCTGTGAATAGTGTGAGTCTGGAGGGAGTCAGCCACCATGCTGCAATTGAAATTTTGCAAAATGC ACCTGAAGATGTGACACTTGTTATCTCTCAGCCAAAAGAAAAGATATCCAAAGTGCCTTCTACTCCTGTG CATCTCACCAATGAGATGAAAAACTACATGAAGAAATCTTCCTACATGCAAGACAGTGCTATAGATTCTT CTTCCAAGGATCACCACTGGTCACGTGGTACCCTGAGGCACATCTCGGAGAACTCCTTTGGGCCATCTGG GGGCCTGCGGGAAGGAAGCCTGAGTTCTCAAGATTCCAGGACTGAGAGTGCCAGCTTGTCTCAAAGCCAG GTCAATGGTTTCTTTGCCAGCCATTTAGGTGACCAAACCTGGCAGGAATCACAGCATGGCAGCCCTTCCC CATCTGTAATATCCAAAGCCACCGAGAAAGAGACTTTCACTGATAGTAACCAAAGCAAAACTAAAAAGCC AGGCATTTCTGATGTAACTGATTACTCAGACCGTGGAGATTCAGACATGGATGAAGCCACTTACTCCAGC AGTCAGGATCATCAAACACCAAAACAGGAATCTTCCTCTTCAGTGAATACATCCAACAAGATGAATTTTA AAACTTTTTCTTCATCACCTCCTAAGCCTGGAGATATCTTTGAGGTTGAACTGGCTAAAAATGATAACAG CTTGGGGATAAGTGTCACGGGAGGTGTGAATACGAGTGTCAGACATGGTGGCATTTATGTGAAAGCTGTT ATTCCCCAGGGAGCAGCAGAGTCTGATGGTAGAATTCACAAAGGTGATCGCGTCCTAGCTGTCAATGGAG TTAGTCTAGAAGGAGCCACCCATAAGCAAGCTGTGGAAACACTGAGAAATACAGGACAGGTGGTTCATCT GTTATTAGAAAAGGGACAATCTCCAACATCTAAAGAACATGTCCCGGTAACCCCACAGTGTACCCTTTCA GATCAGAATGCCCAAGGTCAAGGCCCAGAAAAAGTGAAGAAAACAACTCAGGTCAAAGACTACAGCTTTG TCACTGAAGAAAATACATTTGAGGTAAAATTATTTAAAAATAGCTCAGGTCTAGGATTCAGTTTTTCTCG AGAAGATAATCTTATACCGGAGCAAATTAATGCCAGCATAGTAAGGGTTAAAAAGCTCTTTCCTGGACAG CCAGCAGCAGAAAGTGGAAAAATTGATGTAGGAGATGTTATCTTGAAAGTGAATGGAGCCTCTTTGAAAG GACTATCTCAGCAGGAAGTCATATCTGCTCTCAGGGGAACTGCTCCAGAAGTATTCTTGCTTCTCTGCAG ACCTCCACCTGGTGTGCTACCGGAAATTGATACTGCGCTTTTGACCCCACTTCAGTCTCCAGCACAAGTA CTTCCAAACAGCAGTAAAGACTCTTCTCAGCCATCATGTGTGGAGCAAAGCACCAGCTCAGATGAAAATG AAATGTCAGACAAAAGCAAAAAACAGTGCAAGTCCCCATCCAGAAGAGACAGTTACAGTGACAGCAGTGG GAGTGGAGAAGATGACTTAGTGACAGCTCCAGCAAACATATCAAATTCGACCTGGAGTTCAGCTTTGCAT CAGACTCTAAGCAACATGGTATCACAGGCACAGAGTCATCATGAAGCACCCAAGAGTCAAGAAGATACCA TTTGTACCATGTTTTACTATCCTCAGAAAATTCCCAATAAACCAGAGTTTGAGGACAGTAATCCTTCCCC TCTACCACCGGATATGGCTCCTGGGCAGAGTTATCAACCCCAATCAGAATCTGCTTCCTCTAGTTCGATG GATAAGTATCATATACATCACATTTCTGAACCAACTAGACAAGAAAACTGGACACCTTTGAAAAATGACT TGGAAAATCACCTTGAAGACTTTGAACTGGAAGTAGAACTCCTCATTACCCTAATTAAATCAGAAAAAGG AAGCCTGGGTTTTACAGTAACCAAAGGCAATCAGAGAATTGGTTGTTATGTTCATGATGTCATACAGGAT CCAGCCAAAAGTGATGGAAGGCTAAAACCTGGGGACCGGCTCATAAAGGTTAATGATACAGATGTTACTA ATATGACTCATACAGATGCAGTTAATCTGCTCCGGGCTGCATCCAAAACAGTCAGATTAGTTATTGGACG AGTTCTAGAATTACCCAGAATACCAATGTTGCCTCATTTGCTACCGGACATAACACTAACGTGCAACAAA GAGGAGTTGGGTTTTTCCTTATGTGGAGGTCATGACAGCCTTTATCAAGTGGTATATATTAGTGATATTA ATCCAAGGTCCGTCGCAGCCATTGAGGGTAATCTCCAGCTATTAGATGTCATCCATTATGTGAACGGAGT CAGCACACAAGGAATGACCTTGGAGGAAGTTAACAGAGCATTAGACATGTCACTTCCTTCATTGGTATTG AAAGCAACAAGAAATGATCTTCCAGTGGTCCCCAGCTCAAAGAGGTCTGCTGTTTCAGCTCCAAAGTCAA CCAAAGGCAATGGTTCCTACAGTGTGGGGTCTTGCAGCCAGCCTGCCCTCACTCCTAATGATTCATTCTC CACGGTTGCTGGGGAAGAAATAAATGAAATATCGTACCCCAAAGGAAAATGTTCTACTTATCAGATAAAG GGATCACCAAACTTGACTCTGCCCAAAGAATCTTATATACAAGAAGATGACATTTATGATGATTCCCAAG AAGCTGAAGTTATCCAGTCTCTGCTGGATGTTGTGGATGAGGAAGCCCAGAATCTTTTAAACGAAAATAA TGCAGCAGGATACTCCTGTGGTCCAGGTACATTAAAGATGAATGGGAAGTTATCAGAAGAGAGAACAGAA GATACAGACTGCGATGGTTCACCTTTACCTGAGTATTTTACTGAGGCCACCAAAATGAATGGCTGTGAAG AATATTGTGAAGAAAAAGTAAAAAGTGAAAGCTTAATTCAGAAGCCACAAGAAAAGAAGACTGATGATGA TGAAATAACATGGGGAAATGATGAGTTGCCAATAGAGAGAACAAACCATGAAGATTCTGATAAAGATCAT TCCTTTCTGACAAACGATGAGCTCGCTGTACTCCCTGTCGTCAAAGTGCTTCCCTCTGGTAAATACACGG GTGCCAACTTAAAATCAGTCATTCGAGTCCTGCGGGGTTTGCTAGATCAAGGAATTCCTTCTAAGGAGCT GGAGAATCTTCAAGAATTAAAACCTTTGGATCAGTGTCTAATTGGGCAAACTAAGGAAAACAGAAGGAAG AACAGATATAAAAATATACTTCCCTATGATGCTACAAGAGTGCCTCTTGGAGATGAAGGTGGCTATATCA ATGCCAGCTTCATTAAGATACCAGTTGGGAAAGAAGAGTTCGTTTACATTGCCTGCCAAGGACCACTGCC TACAACTGTTGGAGACTTCTGGCAGATGATTTGGGAGCAAAAATCCACAGTGATAGCCATGATGACTCAA GAAGTAGAAGGAGAAAAAATCAAATGCCAGCGCTATTGGCCCAACATCCTAGGCAAAACAACAATGGTCA GCAACAGACTTCGACTGGCTCTTGTGAGAATGCAGCAGCTGAAGGGCTTTGTGGTGAGGGCAATGACCCT TGAAGATATTCAGACCAGAGAGGTGCGCCATATTTCTCATCTGAATTTCACTGCCTGGCCAGACCATGAT ACACCTTCTCAACCAGATGATCTGCTTACTTTTATCTCCTACATGAGACACATCCACAGATCAGGCCCAA TCATTACGCACTGCAGTGCTGGCATTGGACGTTCAGGGACCCTGATTTGCATAGATGTGGTTCTGGGATT AATCAGTCAGGATCTTGATTTTGACATCTCTGATTTGGTGCGCTGCATGAGACTACAAAGACACGGAATG GTTCAGACAGAGGATCAATATATTTTCTGCTATCAAGTCATCCTTTATGTCCTGACACGTCTTCAAGCAG AAGAAGAGCAAAAACAGCAGCCTCAGCTTCTGAAGTGA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for NM_080683 unedited GGGGTTACANCATTTGTATACGACTCATATAGGCGGCNCGCGAATTCGCACGAGGCTGAG GCGAGGGTGACACACCATGCTCACGGCCCCTGGAGACCGTCGTGCTGGCGAGCCGTGCTC CGTAGCTCCCCGGTCCGCCTCGGCAGCGGTCAGAGTCGCCTACAGGAGTTGAGCCGCCCG CGCCAGAAGGTTTTGGCGAAGCTCTTGGAGAGGCGTCGAGCACAGTAGGGCGGCGGGGGT GCGTTGAGCGCTCGGGGGTCAGGCAGTCGGCCGGGATCGCCGCTGGGGAGCGTTTCCGAG GCGAGGAGGAGGAGGAGGAGATGCTGCTCCTCTTCTCCCCCTCCCCAGGCTCCTTCTACA GCTCCTTCAGCCCACGCCCGCAGCCGCTTGTGGGAGAAGTGGTGGTGGCTCTCGGCGCCC GCGGCGGCTGCCGGCGGCCCGCCCCGACGCCGCGTCCCTGCAGCCCTCGCCCGGCGCTCC AGTAGCAGGACCCGGTCTCGGGACCAGCCGGTAATATGCACGTGTCACTAGCTGAGGCCC TGGAGGTTCGGGGTGGACCACTTCAGGAGGAAGAAATATGGGCTGTATTAAATCAAAGTG CTGAAAGTCTCCAAGAATTATTCAGAAAAGTAAGCCTAGCTGATCCTGCTGCCCTTGGCT TCATCATTTCTCCATGGTCTCTGCTGTTGCTGCCATCTGGTAGTGTGTCATTTACAGATG AAAATATTTNCAATCAGGATCTTCGAGCATTCACTGCACCCAGAGTTCTTCAAAATCAGT CACTAACTTCTCTCTCAGATGTTGAAAAGACCACATTTATTCTCTTGGAATGACACTGTA TTGGGGGGCTGATTATGAGTGCCTCAGACCAACCTATTAAGCTTGGAGATATCTCACAGC TACTGCTTGGATGGTGG 3' Read Nucleotide Sequence (showhide) >OriGene 3' read for NM_080683 unedited AACGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTGTCTGCACACAGTTTT GGCTTGTTCATGTTTTAAGGTGTGTTTTTATTTACAAAGTGAGATAATGATTACAAACAG ATGATGCAGTAACAAACAGATAACTGATAACTCCATTTTCATGAAAAAGTATATAAATAT ATTACAGGAAATTCTATATAGTAAACATTAGAAATTGATACAGTAAACATTTGCTACTTT TTTCTATGCCAATATTACTGTCATTTAAAGCTTAAATACTGGTTTCAAGTATCCCCTATA AAATAACTACTTTATTAAAATATTGGAAAACATTTTTGCTATAAACAAGATTGGTGCATT AAAAATAGACTCACCATGTCCTTGTAACAATGTCTGCTATCATCAAATGCTGCCTTTAAT CATCCCTAAGATCTGCATTGTTTGGTTAGTGTTAAAATTTTGTAAATAATTATCATAGGT TAAAGTAGCTGTAAAAATACAGCATTTCAATATTTTTTATTTTCAAGAAGAATACCCCTC TAAGATAGAGGAGAACATGCATGTTGTATGAACTTGCTGCTCTGTGATCTTTATTTTGGA TAGAGAGCAAGAGTCTGCTGGAGGGTAAGGAGAGAAATGGAAATGCATCCAGAGGCTCTT TTCATGTCACTTCAGAAGCTGAAGCTGCTGGTTTTGCTCTTCTTCTGCTTGGAGACGTGT CAAGGCATAAAGGATGACTTTGTAGCCAAAATATATTGATCCCCTGTCTGAACCATTCGG GTCTTTGTGTCTCATGCCCGGCCCCAATCAGAATGTCAAATTCAAATCCTGACTGTTAAT CCCGAACCCCATTTTTCAATAAAGGTGCCTCGACGTTCAAGGCCCCCTGCAGGGGGAAAG ATGGGCCGAACTGGGGAGGGCTCCAGTGGGAAAAAGAAGCCAAACTCTGGTTGAAAGGGG TATGGGCTCGCCCGCCCGAGAATAAAT
Restriction Sites	NotI-NotI
ACCN	NM_080683
Insert Size	2630 bp
OTI Disclaimer	Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_080683.1, NP_542414.1
RefSeq Size	8573 bp
RefSeq ORF	7458 bp
Locus ID	5783
UniProt ID	Q12923
Domains	Y_phosphatase, B41, PDZ, PTPc_motif
Protein Families	Druggable Genome, Phosphatase
Gene Summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008] Transcript Variant: This variant (1) lacks an in-frame segment of a coding exon, compared to variant 4. The encoded protein (isoform 1) lacks 5 internal amino acids, compared to isoform 4.

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