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CD45 (PTPRC) (NM_080921) Human Untagged Clone
CAT＃: SC128007
PTPRC (untagged)-Human protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 2
CNY 7,968.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC128007 sequence for NM_080921 edited (data generated by NextGen Sequencing)
ATGTATTTGTGGCTTAAACTCTTGGCATTTGGCTTTGCCTTTCTGGACACAGAAGTATTT GTGACAGGGCAAAGCCCAACACCTTCCCCCACTGATGCCTACCTTAATGCCTCTGAAACA ACCACTCTGAGCCCTTCTGGAAGCGCTGTCATTTCAACCACAACAATAGCTACTACTCCA TCTAAGCCAACATGTGATGAAAAATATGCAAACATCACTGTGGATTACTTATATAACAAG GAAACTAAATTATTTACAGCAAAGCTAAATGTTAATGAGAATGTGGAATGTGGAAACAAT ACTTGCACAAACAATGAGGTGCATAACCTTACAGAATGTAAAAATGCGTCTGTTTCCATA TCTCATAATTCATGTACTGCTCCTGATAAGACATTAATATTAGATGTGCCACCAGGGGTT GAAAAGTTTCAGTTACATGATTGTACACAAGTTGAAAAAGCAGATACTACTATTTGTTTA AAATGGAAAAATATTGAAACCTTTACTTGTGATACACAGAATATTACCTACAGATTTCAG TGTGGTAATATGATATTTGATAATAAAGAAATTAAATTAGAAAACCTTGAACCCGAACAT GAGTATAAGTGTGACTCAGAAATACTCTATAATAACCACAAGTTTACTAACGCAAGTAAA ATTATTAAAACAGATTTTGGGAGTCCAGGAGAGCCTCAGATTATTTTTTGTAGAAGTGAA GCTGCACATCAAGGAGTAATTACCTGGAATCCCCCTCAAAGATCATTTCATAATTTTACC CTCTGTTATATAAAAGAGACAGAAAAAGATTGCCTCAATCTGGATAAAAACCTGATCAAA TATGATTTGCAAAATTTAAAACCTTATACGAAATATGTTTTATCATTACATGCCTACATC ATTGCAAAAGTGCAACGTAATGGAAGTGCTGCAATGTGTCATTTCACAACTAAAAGTGCT CCTCCAAGCCAGGTCTGGAACATGACTGTCTCCATGACATCAGATAATAGTATGCATGTC AAGTGTAGGCCTCCCAGGGACCGTAATGGCCCCCATGAACGTTACCATTTGGAAGTTGAA GCTGGAAATACTCTGGTTAGAAATGAGTCGCATAAGAATTGCGATTTCCGTGTAAAAGAT CTTCAATATTCAACAGACTACACTTTTAAGGCCTATTTTCACAATGGAGACTATCCTGGA GAACCCTTTATTTTACATCATTCAACATCTTATAATTCTAAGGCACTGATAGCATTTCTG GCATTTCTGATTATTGTGACATCAATAGCCCTGCTTGTTGTTCTCTACAAAATCTATGAT CTACATAAGAAAAGATCCTGCAATTTAGATGAACAGCAGGAGCTTGTTGAAAGGGATGAT GAAAAACAACTGATGAATGTGGAGCCAATCCATGCAGATATTTTGTTGGAAACTTATAAG AGGAAGATTGCTGATGAAGGAAGACTTTTTCTGGCTGAATTTCAGAGCATCCCGCGGGTG TTCAGCAAGTTTCCTATAAAGGAAGCTCGAAAGCCCTTTAACCAGAATAAAAACCGTTAT GTTGACATTCTTCCTTATGATTATAACCGTGTTGAACTCTCTGAGATAAACGGAGATGCA GGGTCAAACTACATAAATGCCAGCTATATTGATGGTTTCAAAGAACCCAGGAAATACATT GCTGCACAAGGTCCCAGGGATGAAACTGTTGATGATTTCTGGAGGATGATTTGGGAACAG AAAGCCACAGTTATTGTCATGGTCACTCGATGTGAAGAAGGAAACAGGAACAAGTGTGCA GAATACTGGCCGTCAATGGAAGAGGGTACTCGGGCTTTTGGAGATGTTGTTGTAAAGATC AACCAGCACAAAAGATGTCCAGATTACATCATTCAGAAATTGAACATTGTAAATAAAAAA GAAAAAGCAACTGGAAGAGAGGTGACTCACATTCAGTTCACCAGCTGGCCAGACCACGGG GTGCCTGAGGATCCTCACTTGCTCCTCAAACTGAGAAGGAGAGTGAATGCCTTCAGCAAT TTCTTCAGTGGTCCCATTGTGGTGCACTGCAGTGCTGGTGTTGGGCGCACAGGAACCTAT ATCGGAATTGATGCCATGCTAGAAGGCCTGGAAGCCGAGAACAAAGTGGATGTTTATGGT TATGTTGTCAAGCTAAGGCGACAGAGATGCCTGATGGTTCAAGTAGAGGCCCAGTACATC TTGATCCATCAGGCTTTGGTGGAATACAATCAGTTTGGAGAAACAGAAGTGAATTTGTCT GAATTACATCCATATCTACATAACATGAAGAAAAGGGATCCACCCAGTGAGCCGTCTCCA CTAGAGGCTGAATTCCAGAGACTTCCTTCATATAGGAGCTGGAGGACACAGCACATTGGA AATCAAGAAGAAAATAAAAGTAAAAACAGGAATTCTAATGTCATCCCATATGACTATAAC AGAGTGCCACTTAAACATGAGCTGGAAATGAGTAAAGAGAGTGAGCATGATTCAGATGAA TCCTCTGATGATGACAGTGATTCAGAGGAACCAAGCAAATACATCAATGCATCTTTTATA ATGAGCTACTGGAAACCTGAAGTGATGATTGCTGCTCAGGGACCACTGAAGGAGACCATT GGTGACTTTTGGCAGATGATCTTCCAAAGAAAAGTCAAAGTTATTGTTATGCTGACAGAA CTGAAACATGGAGACCAGGAAATCTGTGCTCAGTACTGGGGAGAAGGAAAGCAAACATAT GGAGATATTGAAGTTGACCTGAAAGACACAGACAAATCTTCAACTTATACCCTTCGTGTC TTTGAACTGAGACATTCCAAGAGGAAAGACTCTCGAACTGTGTACCAGTACCAATATACA AACTGGAGTGTGGAGCAGCTTCCTGCAGAACCCAAGGAATTAATCTCTATGATTCAGGTC GTCAAACAAAAACTTCCCCAGAAGAATTCCTCTGAAGGGAACAAGCATCACAAGAGTACA CCTCTACTCATTCACTGCAGGGATGGATCTCAGCAAACGGGAATATTTTGTGCTTTGTTA AATCTCTTAGAAAGTGCGGAAACAGAAGAGGTAGTGGATATTTTTCAAGTGGTAAAAGCT CTACGCAAAGCTAGGCCAGGCATGGTTTCCACATTCGAGCAATATCAATTCCTATATGAC GTCATTGCCAGCACCTACCCTGCTCAGAATGGACAAGTAAAGAAAAACAACCATCAAGAA GATAAAATTGAATTTGATAATGAAGTGGACAAAGTAAAGCAGGATGCTAATTGTGTTAAT CCACTTGGTGCCCCAGAAAAGCTCCCTGAAGCAAAGGAACAGGCTGAAGGTTCTGAACCC ACGAGTGGCACTGAGGGGCCAGAACATTCTGTCAATGGTCCTGCAAGTCCAGCTTTAAAT CAAGGTTCATAG Clone variation with respect to NM_080921.2 1827 c=>t >OriGene 5' read for NM_080921 unedited
NTTTGCGGNATTTTGTAATACGACTCACTTATAGGGCGGCCGCGAATTCGCACGAGGTCT GATAAGACAACAGTGGAGAAAGGACGCATGCTGTTTCTTAGGGACACGGCTGACTTCCAG ATATGACCATGTATTTGTGGCTTAAACTCTTGGCATTTGGCTTTGCCTTTCTGGACACAG AAGTATTTGTGACAGGGCAAAGCCCAACACCTTCCCCCACTGATGCCTACCTTAATGCCT CTGAAACAACCACTCTGAGCCCTTCTGGAAGCGCTGTCATTTCAACCACAACAATAGCTA CTACTCCATCTAAGCCAACATGTGATGAAAAATATGCAAACATCACTGTGGATTACTTAT ATAACAAGGAAACTAAATTATTTACAGCAAAGCTAAATGTTAATGAGAATGTGGAATGTG GAAACAATACTTGCACAAACAATGAGGTGCATAACCTTACAGAATGTAAAAATGCGTCTG TTTCCATATCTCATAATTCATGTACTGCTCCTGATAAGACATTAATATTAGATGTGCCAC CAGGGGTTGAAAAGTTTCAGTTACATGATTGTACACAAGTTGAAAAAGCAGATACTACTA TTTGTTTAAAATGGAAAAATATTGAAACCTTTACTTGTGATACACAGAATATTACCTACA GATTTCAGTGTGGTAATATGATATTTGATAATAAAGAAATTAAATTAGAAAACCTTGAAC CCGAACATGAGTATAAGTGTGACTCAGAAATACTCTATAATAACCACAAGTTTACTTAAC GCAAGTAAATTATTAAAACAGATTTTGGGAGTCCAGGAGAGCCTCAGATATTTTTTGTAG AAAGTGAGCTGCACATCAAGGAGTAATTACCTGGAATCCCCTCAAAGACATTTCATAATT TACCCTCTGTATATAAAGAGACAGAAAAGATGCCTCATCTGA >Forward primer walk for NM_080921 unedited
AAAAAAGCTCCTAAGACGTGNGCTTTTNCTTTGTTTTTATGNAGNAAAAAAACATTTTAT ATTAGAAGTGTTAACTTAGCTTGAAGGATCTGTTTTTAAAATCATAAACTGTGTGCAGAC TCAATGAAATCATGTGCACTTTCTGAAATGACACTGAAGGAGTCCTCCATCGGCCGCCCC GAAAGTAGCCCGCGGGCGCGCGGGGGGGGCCCGAGGCCCGGGCTGGGCCCCGTGCGGGGC CGCCGGGCCCCCGGCCGCGGCCGCCGCTGGTCCCCCCGGGCTCGGCCGCCAGCACGCCGG CCCCCCCACCGCCCGGACCGAGCTCCGGGGGGCCCCCGCCCCAGCGGCCGCAGGGGCGCG TGGCTCACCGGCGGAACGCGGGCCCCCGCCCGGCGCCTCGCGGGGCGGTCCGCCGGCCCG CCCGGGTTGCTGGGGCCGCCCCGCGGGCGGCCAACCTCGCCCGCCGCCGCGCGGTGCGCG CCCCCGCTGTTCCGGCGCGAGCCGGTGGGCGGGGGCGCGGCCGCCCAGTAGCCGCCCGCC CCGGACCCGGGGCGCGCCCCCACCGCCCTGCGAGACCCCGGGCCGTGTATGGGGCGCTCT TTCAGCCTGCGCCCGGCTTGTGCGCCCCGCCCGCGCGCGACGGGGACGAGGTGGTCCGGG CTGCTGGCCGCGATCGCCGGCCGCGGATCGCGGCGCGCTGATCGCCCCCCCGCGCGCCCC CGTGTTCTCCCCCCCCCCGCCACGCCCGTGCCCGCGCGCGCGCGCCCCCGAGATTGCTCC GGCCCGGTGACCCCCGCGGCGCGCGCGGCGCGTATGACACCCACGGCGCCCCCCGGCCGC GGGGTGTGCGACGCGGCGGGTGTGGCGCCCCCGCGCCTGTAGGCCGCCCCCGCCCGCGAG CCCGCCGAACGCCCCCGCCCGCCGCGGCTCCCGCGCGGGGTGCCCCCGTCACGCCCGCGC CGCGCGCCGCGCGCAAG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_080921 |
| Insert Size | 4700 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_080921.1, NP_563578.1 |
| RefSeq Size | 4543 bp |
| RefSeq ORF | 3432 bp |
| Locus ID | 5788 |
| UniProt ID | P08575 |
| Domains | Y_phosphatase, FN3 |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Phosphatase, Transmembrane |
| Protein Pathways | Cell adhesion molecules (CAMs), Fc gamma R-mediated phagocytosis, Primary immunodeficiency, T cell receptor signaling pathway |
| Gene Summary | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012] Transcript Variant: This variant (2) lacks three in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. |
Documents
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| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC224220 | PTPRC (Myc-DDK-tagged)-Human protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 2 |
CNY 7,960.00 |
|
| RC224220L3 | Lenti ORF clone of Human protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 2, Myc-DDK-tagged |
CNY 13,300.00 |
|
| RC224220L4 | Lenti ORF clone of Human protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 2, mGFP tagged |
CNY 13,300.00 |
|
| RG224220 | PTPRC (tGFP-tagged) - Human protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 2 |
CNY 9,560.00 |
