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KCNQ1 (NM_000218) Human Untagged Clone
CAT＃: SC300026
KCNQ1 (untagged)-Human potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1), transcript variant 1
CNY 7,440.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1; LQT; LQT1; RWS; SQT2; WRS |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_000218 edited
GCAGGCCCTCCTCGTTATGGCCGCGGCCTCCTCCCCGCCCAGGGCCGAGAGGAAGCGCTG GGGTTGGGGCCGCCTGCCAGGCGCCCGCCGGGGCAGCGCGGGCCTGGCCAAGAAGTGCCC CTTCTCGCTGGAGCTGGCGGAGGGCGGCCCGGCGGGCGGCGCGCTCTACGCGCCCATCGC GCCCGGCGCCCCAGGTCCCGCGCCCCCTGCGTCCCCGGCCGCGCCCGCCGCGCCCCCAGT TGCCTCCGACCTTGGCCCGCGGCCGCCGGTGAGCCTAGACCCGCGCGTCTCCATCTACAG CACGCGCCGCCCGGTGTTGGCGCGCACCCACGTCCAGGGCCGCGTCTACAACTTCCTCGA GCGTCCCACCGGCTGGAAATGCTTCGTTTACCACTTCGCCGTCTTCCTCATCGTCCTGGT CTGCCTCATCTTCAGCGTGCTGTCCACCATCGAGCAGTATGCCGCCCTGGCCACGGGGAC TCTCTTCTGGATGGAGATCGTGCTGGTGGTGTTCTTCGGGACGGAGTACGTGGTCCGCCT CTGGTCCGCCGGCTGCCGCAGCAAGTACGTGGGCCTCTGGGGGCGGCTGCGCTTTGCCCG GAAGCCCATTTCCATCATCGACCTCATCGTGGTCGTGGCCTCCATGGTGGTCCTCTGCGT GGGCTCCAAGGGGCAGGTGTTTGCCACGTCGGCCATCAGGGGCATCCGCTTCCTGCAGAT CCTGAGGATGCTACACGTCGACCGCCAGGGAGGCACCTGGAGGCTCCTGGGCTCCGTGGT CTTCATCCACCGCCAGGAGCTGATAACCACCCTGTACATCGGCTTCCTGGGCCTCATCTT CTCCTCGTACTTTGTGTACCTGGCTGAGAAGGACGCGGTGAACGAGTCAGGCCGCGTGGA GTTCGGCAGCTACGCAGATGCGCTGTGGTGGGGGGTGGTCACAGTCACCACCATCGGCTA TGGGGACAAGGTGCCCCAGACGTGGGTCGGGAAGACCATCGCCTCCTGCTTCTCTGTCTT TGCCATCTCCTTCTTTGCGCTCCCAGCGGGGATTCTTGGCTCGGGGTTTGCCCTGAAGGT GCAGCAGAAGCAGAGGCAGAAGCACTTCAACCGGCAGATCCCGGCGGCAGCCTCACTCAT TCAGACCGCATGGAGGTGCTATGCTGCCGAGAACCCCGACTCCTCCACCTGGAAGATCTA CATCCGGAAGGCCCCCCGGAGCCACACTCTGCTGTCACCCAGCCCCAAACCCAAGAAGTC TGTGGTGGTAAAGAAAAAAAAGTTCAAGCTGGACAAAGACAATGGGGTGACTCCTGGAGA GAAGATGCTCACAGTCCCCCATATCACGTGCGACCCCCCAGAAGAGCGGCGGCTGGACCA CTTCTCTGTCGACGGCTATGACAGTTCTGTAAGGAAGAGCCCAACACTGCTGGAAGTGAG CATGCCCCATTTCATGAGAACCAACAGCTTCGCCGAGGACCTGGACCTGGAAGGGGAGAC TCTGCTGACACCCATCACCCACATCTCACAGCTGCGGGAACACCATCGGGCCACCATTAA GGTCATTCGACGCATGCAGTACTTTGTGGCCAAGAAGAAATTCCAGCAAGCGCGGAAGCC TTACGATGTGCGGGACGTCATTGAGCAGTACTCGCAGGGCCACCTCAACCTCATGGTGCG CATCAAGGAGCTGCAGAGGAGGCTGGACCAGTCCATTGGGAAGCCCTCACTGTTCATCTC CGTCTCAGAAAAGAGCAAGGATCGCGGCAGCAACACGATCGGCGCCCGCCTGAACCGAGT AGAAGACAAGGTGACGCAGCTGGACCAGAGGCTGGCACTCATCACCGACATGCTTCACCA GCTGCTCTCCTTGCACGGTGGCAGCACCCCCGGCAGCGGCGGCCCCCCCAGAGAGGGCGG GGCCCACATCACCCAGCCCTGCGGCAGTGGCGGCTCCGTCGACCCTGAGCTCTTCCTGCC CAGCAACACCCTGCCCACCTACGAGCAGCTGACCGTGCCCAGGAGGGGCCCCGATGAGGG GTCCTGAGGAGGGGATGGGGCTGGGGGATGGGCCTGAGTGAGAGGGGAGGCCAAGAGTGG CCCCACCTGGCCCTCTCTGAAGGAGGCCACCTCCTAAAAGGCCCAGAGAGAAGAGCCCCA CTCTCAGAGGCCCCAATACCCCATGGACCATGCTGTCTGGCACAGCCTGCACTTGGGGGC TCAGCAAGGCCACCTCTTCCTGGCCGGTGTGGGGGCCCCGTCTCAGGTCTGAGTTGTTAC CCCAAGCGCCCTGGCCCCCACATGGTGATGTTGACATCACTGGCATGGTGGTTGGGACCC AGTGGCAGGGCACAGGGCCTGGCCCATGTATGGCCAGGAAGTAGCACAGGCTGAGTGCAG GCCCACCCTGCTTGGCCCAGGGGGCTTCCTGAGGGGAGACAGAGCAACCCCTGGACCCCA GCCTCAAATCCAGGACCCTGCCAGGCACAGGCAGGGCAGGACCAGCCCACGCTGACTACA GGGCCGCCGGCAATAAAAGCCCAGGAGCCCATTTGGAGGGCCTGGGCCTGGCTCCCTCAC TCTCAGGAAATGCTGACCCATGGGCAGGAGACTGTGGAGACTGCTCCTGAGCCCCCAGCT TCCAGCAGGAGGGACAGTCTCACCATTTCCCCAGGGCACGTGGTTGAGTGGGGGGAACGC CCACTTCCCTGGGTTAGACTGCCAGCTCTTCCTAGCTGGAGAGGAGCCCTGCCTCTCCGC CCCTGAGCCCACTGTGCGTGGGGCTCCCGCCTCCAACCCCTCGCCCAGTCCCAGCAGCCA GCCAAACACACAGAAGGGGACTGCCACCTCCCCTTGCCAGCTGTTGAGCCGCAGAGAAGT GACGGTTCCTACACAGGACAGGGGTTCCTTCTGGGCATTACGTCGCATAGAAATCAATAA TTTGTGGTGATTTGGATCTGTGTTTTAATGAGTTTCACGGTGTGATTTTGATTATTAATT GTGCAAGCTTTTCCTAATAAACGTGGAGAATCCCAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAA >OriGene 5' read for NM_000218 unedited
NACGTCAGCATTTGNTATACGACTCACTATAGGGCGGCCGCGCAATTCGCAGGCCCTCCT CGTTATGGCCGCGGCCTCCTCCCCGCCCAGGCCGAGAGGAAGCGCTGGGGTTGGGGCCGC CTGCCAGGCGCCCGCCGGGGCAGCGCGGGCCTGGCCAAGAAGTGCCCCTTCTCGCTGGAG CTGGCGGAGGGCGGCCCGGCGGGCGGCGCGCTCTACGCGCCCATCGCGCCCGGCGCCCCA GGTCCCGCGCCCCCTGCGTCCCCGGCCGCGCCCGCCGCGCCCCCAGTTGCCTCCGACCTT GGCCCGCGGCCGCCGGTGAGCCTAGACCCGCGCGTCTCCATCTACAGCACGCGCCGCCCG GTGTTGGCGCGCACCCACGTCCAGGGCCGCGTCTACAACTTCCTCGAGCGTCCCACCGGC TGGAAATGCTTCGTTTACCACTTCGCCGTCTTCCTCATCGTCCTGGTCTGCCTCATCTTC AGCGTGCTGTCCACCATCGAGCAGTATGCCGCCCTGGCCACGGGGACTCTCTTCTGGATG GAGATCGTGCTGGTGGTGTTCTTCGGGACGGAGTACGTGGTCCGCCTCTGGTCCGCCGGC TGCCGCAGCAAGTACGTGGGCCTCTGGGGGCGGCTGCGCTTTGCCCGGAAGCCCATTTCC ATCATCGAACTCATCGTGGTCGTGGCCTCCATGGTGGGCCTCTGCGTGGGCTCCAAAGGG CAAGTGTTTGCCACGTACGCCATTCAGGGCATCCGCTTTCCTGCAATCCTGAGGATGCTA CACCTCGACCGCCAGGGAGGCACCTGGAGGCTCCTGGGCTCCGTGGTCCTTATTCCCCGC CAGGAGCTGAAAACCCCCTGTACAACGGCTTCCTGGGCCTCACTTTCTCTCGAACTTGGG TACTG >OriGene 3' read for NM_000218 unedited
CTCATTGCTNGATGGTCAACTTGCCAGGGCCAGCAGAGCACTGGGGNAGGGTCACAGGGC TGCCACCCGGGATCTGTTCAGGAAACAGCTATGATCGCGGCCGCAATCTAGAGTCGAGTT TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGGATTCTCCACGTTTATTAAGAAAA GCTTGCACAATTAATAATCAAAATCACACCGTGAAACTCATTAAAACACAGATCCCAATC ACCACAAATTATTGATTTCTATGCGACGTAATGCCCAAAAGGAACCCCTGTCCTGTGTAG GAAACCGTCACTTTTCTGCGGCTCAACAGCTGGCAAGGGGAGGTGGCAGTCCCCTTCTGT GTGTTTGGCTGGCTGCTGGGACTGGGCGAGGGGTTGGAGGCCGGAGCCCCACGCACAGTG GGCTCAAGGGCGGAGAGGCAGGGCTCCTCTCCAGCTAGGAAGAGCTGGCAGTCTAACCCA GGGAAGTGGGCGTTCCCCCCACTCAACCACGTGCCCTGGGGAAATGGTGAGACTGTCCCT CCTGCTGGAAGCTGGGGGCTCAAGAACAATCTCCACAGTCTCCTGCCCATGGGTCAGCAT TTCCTGAGAGTGAGGGAGCCAGGCCCAGGCCCTCCAAATGGGCTCCTGGGCTTTTATTGC CCGCGGCCCTGTAATCAGCGTGGGCTTGTCCTGCCCTGCCTGTGCCTGGCAGGGTCCTTG AATTGAAGCTGGGGTCCAAGGGGTGCTCTGTCTCCCCTCAGGAACCCCCTGGGCAAACAG GGTGGGCCTGCCCTCAACCTGGGCTACTTTCTTGGCCTACATGGGCCAGGCCTTGGGCCC TGCCCTTGGGTCCAACCACCATGCCCATGATGGTAACATTCACATGTGGGGGGCCAAGGC CCTTGGGGTAA |
| Restriction Sites | Please inquire |
| ACCN | NM_000218 |
| Insert Size | 3100 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000218.2, NP_000209.2 |
| RefSeq Size | 3262 bp |
| RefSeq ORF | 2031 bp |
| Locus ID | 3784 |
| UniProt ID | P51787 |
| Protein Families | Druggable Genome, Ion Channels: Potassium, Transmembrane |
| Protein Pathways | Vibrio cholerae infection |
| Gene Summary | This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011] Transcript Variant: This variant (1) encodes the longer isoform (1). |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Single-channel basis for the slow activation of the repolarizing cardiac potassium current, IKs
,Daniel Werry, Jodene Eldstrom, Zhuren Wang, and David Fedida,
PNAS, Mar 2013; 110: E996 - E1005.
[KCNQ1]
|
|
Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of Iks
,Jodene Eldstrom, Hongjian Xu, Daniel Werry, Congbao Kang, Matthew E. Loewen, Amanda Degenhardt, Shubhayan Sanatani, Glen F. Tibbits, Charles Sanders, and David Fedida,
J. Gen. Physiol., Apr 2010; 135: 433 - 448
[KCNQ1]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC219869 | KCNQ1 (Myc-DDK-tagged)-Human potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1), transcript variant 1 |
CNY 7,424.00 |
|
| RC219869L1 | Lenti ORF clone of Human potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1), transcript variant 1, Myc-DDK-tagged |
CNY 9,824.00 |
|
| RC219869L2 | Lenti ORF clone of Human potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1), transcript variant 1, mGFP tagged |
CNY 9,120.00 |
|
| RC219869L3 | Lenti ORF clone of Human potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1), transcript variant 1, Myc-DDK-tagged |
CNY 9,120.00 |
|
| RC219869L4 | Lenti ORF clone of Human potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1), transcript variant 1, mGFP tagged |
CNY 9,824.00 |
|
| RG219869 | KCNQ1 (tGFP-tagged) - Human potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1), transcript variant 1 |
CNY 9,024.00 |
