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Hairless (HR) (NM_018411) Human Untagged Clone
CAT＃: SC304590
HR (untagged)-Human hairless homolog (mouse) (HR), transcript variant 2
CNY 21,850.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>SC304590 representing NM_018411.
Blue=Insert sequence Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGGAGAGTACGCCCAGCTTCCTGAAGGGCACCCCAACCTGGGAGAAGACGGCCCCAGAGAACGGCATC GTGAGACAGGAGCCCGGCAGCCCGCCTCGAGATGGACTGCACCATGGGCCGCTGTGCCTGGGAGAGCCT GCTCCCTTTTGGAGGGGCGTCCTGAGCACCCCAGACTCCTGGCTTCCCCCTGGCTTCCCCCAGGGCCCC AAGGACATGCTCCCACTTGTGGAGGGCGAGGGCCCCCAGAATGGGGAGAGGAAGGTCAACTGGCTGGGC AGCAAAGAGGGACTGCGCTGGAAGGAGGCCATGCTTACCCATCCGCTGGCATTCTGCGGGCCAGCGTGC CCACCTCGCTGTGGCCCCCTGATGCCTGAGCATAGTGGTGGCCATCTCAAGAGTGACCCTGTGGCCTTC CGGCCCTGGCACTGCCCTTTCCTTCTGGAGACCAAGATCCTGGAGCGAGCTCCCTTCTGGGTGCCCACC TGCTTGCCACCCTACCTAGTGTCTGGCCTGCCCCCAGAGCATCCATGTGACTGGCCCCTGACCCCGCAC CCCTGGGTATACTCCGGGGGCCAGCCCAAAGTGCCCTCTGCCTTCAGCTTAGGCAGCAAGGGCTTTTAC TACAAGGATCCGAGCATTCCCAGGTTGGCAAAGGAGCCCTTGGCAGCTGCGGAACCTGGGTTGTTTGGC TTAAACTCTGGTGGGCACCTGCAGAGAGCCGGGGAGGCCGAACGCCCTTCACTGCACCAGAGGGATGGA GAGATGGGAGCTGGCCGGCAGCAGAATCCTTGCCCGCTCTTCCTGGGGCAGCCAGACACTGTGCCCTGG ACCTCCTGGCCCGCTTGTCCCCCAGGCCTTGTTCATACTCTTGGCAACGTCTGGGCTGGGCCAGGCGAT GGGAACCTTGGGTACCAGCTGGGGCCACCAGCAACACCAAGGTGCCCCTCTCCTGAGCCGCCTGTCACC CAGCGGGGCTGCTGTTCATCCTACCCACCCACTAAAGGTGGGGGTCTTGGCCCTTGTGGGAAGTGCCAG GAGGGCCTGGAGGGGGGTGCCAGTGGAGCCAGCGAACCCAGCGAGGAAGTGAACAAGGCCTCTGGCCCC AGGGCCTGTCCCCCCAGCCACCACACCAAGCTGAAGAAGACATGGCTCACACGGCACTCGGAGCAGTTT GAATGTCCACGCGGCTGCCCTGAGGTCGAGGAGAGGCCGGTTGCTCGGCTCCGGGCCCTCAAAAGGGCA GGCAGCCCCGAGGTCCAGGGAGCAATGGGCAGTCCAGCCCCCAAGCGGCCACCGGACCCTTTTCCAGGC ACTGCAGAACAGGGGGCTGGGGGTTGGCAGGAGGTGCGGGACACATCGATAGGGAACAAGGATGTGGAC TCGGGACAGCATGATGAGCAGAAAGGACCCCAAGATGGCCAGGCCAGTCTCCAGGACCCGGGACTTCAG GACATACCATGCCTGGCTCTCCCTGCAAAACTGGCTCAATGCCAAAGTTGTGCCCAGGCAGCTGGAGAG GGAGGAGGGCACGCCTGCCACTCTCAGCAAGTGCGGAGATCGCCTCTGGGAGGGGAGCTGCAGCAGGAG GAAGACACAGCCACCAACTCCAGCTCTGAGGAAGGCCCAGGGTCCGGCCCTGACAGCCGGCTCAGCACA GGCCTCGCCAAGCACCTGCTCAGTGGTTTGGGGGACCGACTGTGCCGCCTGCTGCGGAGGGAGCGGGAG GCCCTGGCTTGGGCCCAGCGGGAAGGCCAAGGGCCAGCCGTGACAGAGGACAGCCCAGGCATTCCACGC TGCTGCAGCCGTTGCCACCATGGACTCTTCAACACCCACTGGCGATGTCCCCGCTGCAGCCACCGGCTG TGTGTGGCCTGTGGTCGTGTGGCAGGCACTGGGCGGGCCAGGGAGAAAGCAGGCTTTCAGGAGCAGTCC GCGGAGGAGTGCACGCAGGAGGCCGGGCACGCTGCCTGTTCCCTGATGCTGACCCAGTTTGTCTCCAGC CAGGCTTTGGCAGAGCTGAGCACTGCAATGCACCAGGTCTGGGTCAAGTTTGATATCCGGGGGCACTGC CCCTGCCAAGCTGATGCCCGGGTATGGGCCCCCGGGGATGCAGGCCAGCAGAAGGAATCAACACAGAAA ACGCCCCCAACTCCACAACCTTCCTGCAATGGCGACACCCACAGGACCAAGAGCATCAAAGAGGAGACC CCCGATTCCGCTGAGACCCCAGCAGAGGACCGTGCTGGCCGAGGGCCCCTGCCTTGTCCTTCTCTCTGC GAACTGCTGGCTTCTACCGCGGTCAAACTCTGCTTGGGCCATGAGCGAATACACATGGCCTTCGCCCCC GTCACTCCGGCCCTGCCCAGTGATGACCGCATCACCAACATCCTGGACAGCATTATCGCACAGGTGGTG GAACGGAAGATCCAGGAGAAAGCCCTGGGGCCGGGGCTTCGAGCTGGCCCGGGTCTGCGCAAGGGCCTG GGCCTGCCCCTCTCTCCAGTGCGGCCCCGGCTGCCTCCCCCAGGGGCTTTGCTGTGGCTGCAGGAGCCC CAGCCTTGCCCTCGGCGTGGCTTCCACCTCTTCCAGGAGCACTGGAGGCAGGGCCAGCCTGTGTTGGTG TCAGGGATCCAAAGGACATTGCAGGGCAACCTGTGGGGGACAGAAGCTCTTGGGGCACTTGGAGGCCAG GTGCAGGCGCTGAGCCCCCTCGGACCTCCCCAGCCCAGCAGCCTGGGCAGCACAACATTCTGGGAGGGC TTCTCCTGGCCTGAGCTTCGCCCAAAGTCAGACGAGGGCTCTGTCCTCCTGCTGCACCGAGCTTTGGGG GATGAGGACACCAGCAGGGTGGAGAACCTAGCTGCCAGTCTGCCACTTCCGGAGTACTGCGCCCTCCAT GGAAAACTCAACCTGGCTTCCTACCTCCCACCGGGCCTTGCCCTGCGTCCACTGGAGCCCCAGCTCTGG GCAGCCTATGGTGTGAGCCCGCACCGGGGACACCTGGGGACCAAGAACCTCTGTGTGGAGGTGGCCGAC CTGGTCAGCATCCTGGTGCATGCCGACACACCACTGCCTGCCTGGCACCGGGCACAGAAAGACTTCCTT TCAGGCCTGGACGGGGAGGGGCTCTGGTCTCCGGGCAGCCAGGTCAGCACTGTGTGGCACGTGTTCCGG GCACAGGACGCCCAGCGCATCCGCCGCTTTCTCCAGATGGTGCAGGGCCTGGTGAGCACAGTCAGCGTC ACTCAGCACTTCCTCTCCCCTGAGACCTCTGCCCTCTCTGCTCAGCTCTGCCACCAGGGACCCAGCCTT CCCCCTGACTGCCACCTGCTTTATGCCCAGATGGACTGGGCTGTGTTCCAAGCAGTGAAGGTGGCCGTG GGGACATTACAGGAGGCCAAATAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_018411 |
| Insert Size | 3405 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_018411.4 |
| RefSeq Size | 5363 bp |
| RefSeq ORF | 3405 bp |
| Locus ID | 55806 |
| UniProt ID | O43593 |
| Protein Families | Druggable Genome, Transcription Factors |
| MW | 121.9 kDa |
| Gene Summary | This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014] Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a protein (isoform 2) that has a shorter C-terminus, compared to isoform 1. Sequence Note: This RefSeq record represents the hairless protein encoded by the primary ORF. Four upstream ORFs (U1HR-U4HR), which may regulate translation of the primary ORF as described in PMID:19122663, are also annotated on this sequence. |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC221977 | HR (Myc-DDK-tagged)-Human hairless homolog (mouse) (HR), transcript variant 2 |
CNY 7,896.00 |
|
| RC221977L3 | Lenti ORF clone of Human hairless homolog (mouse) (HR), transcript variant 2, Myc-DDK-tagged |
CNY 13,210.00 |
|
| RC221977L4 | Lenti ORF clone of Human hairless homolog (mouse) (HR), transcript variant 2, mGFP tagged |
CNY 13,210.00 |
|
| RG221977 | HR (tGFP-tagged) - Human hairless homolog (mouse) (HR), transcript variant 2 |
CNY 12,450.00 |
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