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TAOK1 (NM_020791) Human Untagged Clone
CAT＃: SC309825
TAOK1 (untagged)-Human TAO kinase 1 (TAOK1), transcript variant 1
CNY 10,464.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | hKFC-B; hTAOK1; KFC-B; MAP3K16; MARKK; PSK-2; PSK2; TAO1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_020791 edited
GCCACCATGCCATCAACTAACAGAGCAGGCAGCCTGAAGGACCCTGAAATTGCAGAGCTC TTCTTCAAAGAAGATCCAGAGAAGCTCTTCACAGATCTCAGAGAAATTGGCCATGGAAGC TTTGGAGCAGTGTATTTTGCACGAGATGTGCGTACCAATGAAGTGGTGGCCATCAAGAAA ATGTCTTATAGTGGAAAGCAGTCTACTGAGAAATGGCAGGATATTATTAAGGAAGTCAAG TTTCTACAAAGAATAAAACATCCCAACAGTATAGAATACAAAGGCTGTTATTTACGTGAA CACACAGCATGGCTTGTAATGGAATATTGTTTAGGATCTGCTTCGGATTTACTAGAAGTT CACAAAAAGCCATTACAAGAAGTGGAAATAGCAGCAATTACACATGGTGCTCTTCAGGGA TTAGCCTACTTACATTCTCATACTATGATTCATAGAGATATCAAAGCAGGAAATATCCTT CTGACAGAACCAGGCCAGGTGAAACTTGCTGACTTTGGCTCTGCTTCCATGGCATCACCT GCCAATTCCTTTGTGGGAACGCCGTATTGGATGGCCCCAGAAGTAATTTTAGCCATGGAT GAAGGACAATATGATGGCAAAGTAGATGTGTGGTCTCTTGGAATAACATGTATTGAACTA GCGGAAAGGAAGCCTCCTTTATTTAATATGAATGCAATGAGTGCCTTATATCACATAGCC CAAAATGAATCCCCTACACTACAGTCTAATGAATGGTCTGATTATTTTCGCAACTTTGTA GATTCTTGCCTCCAGAAAATCCCTCAAGATCGACCTACATCAGAGGAACTTTTAAAGCAC ATATTTGTTCTTCGGGAGCGCCCTGAAACCGTGTTAATAGATCTCATTCAGAGGACAAAG GATGCAGTAAGAGAGCTGGACAATCTGCAGTATCGAAAGATGAAGAAACTCCTTTTCCAG GAGGCACATAATGGACCAGCAGTAGAAGCACAGGAAGAAGAAGAGGAACAAGATCATGGT GTTGGCCGGACAGGAACAGTTAATAGTGTTGGAAGTAATCAATCCATTCCCAGCATGTCC ATCAGTGCCAGCAGCCAAAGCAGTAGTGTTAACAGTCTTCCAGATGTCTCAGATGACAAG AGTGAGCTAGACATGATGGAGGGAGACCACACAGTGATGTCTAACAGTTCTGTTATCCAT TTAAAACCAGAGGAAGAAAATTACAGAGAAGAGGGAGATCCTAGAACAAGAGCATCAGAT CCACAATCTCCACCCCAAGTATCTCGTCACAAATCACACTATCGTAATCGAGAACACTTT GCTACTATACGGACAGCATCACTGGTTACGAGGCAAATGCAAGAACATGAGCAGGACTCT GAGCTTAGAGAACAAATGTCTGGCTATAAGCGAATGAGGCGACAACATCAAAAGCAACTG ATGACTCTGGAAAACAAGCTAAAGGCTGAGATGGATGAACATCGCCTCAGATTAGACAAA GATCTTGAAACTCAGCGTAACAATTTTGCTGCAGAAATGGAGAAACTTATCAAGAAACAC CAGGCTGCCATGGAGAAAGAGGCTAAAGTGATGTCCAATGAAGAGAAAAAATTTCAGCAA CATATTCAGGCCCAACAGAAGAAAGAACTGAATAGTTTTCTCGAGTCCCAGAAAAGAGAG TATAAACTTCGAAAAGAGCAGCTTAAAGAGGAGCTAAATGAAAACCAGAGTACCCCCAAA AAAGAAAAACAGGAGTGGCTTTCAAAGCAGAAGGAGAATATACAGCATTTCCAAGCAGAA GAAGAAGCTAACCTTCTTCGACGTCAAAGACAATACCTAGAGCTGGAATGCCGTCGCTTC AAGAGAAGAATGTTACTTGGGCGTCATAACTTAGAGCAGGACCTTGTCAGGGAGGAGTTA AACAAAAGACAGACTCAGAAGGACTTAGAGCATGCCATGCTACTCCGACAGCATGAATCT ATGCAAGAACTGGAGTTCCGCCACCTCAACACAATTCAGAAGATGCGCTGTGAGTTGATC AGATTACAGCATCAAACTGAGCTCACTAACCAGCTGGAATATAATAAGCGAAGAGAACGA GAACTAAGACGAAAGCATGTCATGGAAGTTCGACAACAGCCTAAGAGTTTGAAGTCTAAA GAACTCCAAATAAAAAAGCAGTTTCAGGATACCTGCAAAATCCAAACCAGACAGTACAAA GCATTAAGAAATCACCTGCTGGAGACTACACCAAAGAGTGAGCACAAAGCTGTTCTGAAA CGGCTCAAGGAGGAACAGACCCGGAAATTAGCTATCTTGGCTGAGCAGTATGATCACAGC ATTAATGAAATGCTCTCCACACAAGCCCTGCGTTTGGATGAAGCACAGGAAGCAGAGTGC CAGGTTTTGAAGATGCAGCTGCAGCAGGAACTGGAGCTGTTGAATGCGTATCAGAGCAAA ATCAAGATGCAAGCTGAGGCACAACATGATCGAGAGCTTCGCGAGCTTGAACAGAGGGTC TCCCTCCGGAGGGCACTCTTAGAACAAAAGATTGAAGAAGAGATGTTGGCTTTGCAGAAT GAGCGCACAGAACGAATACGAAGCCTGTTGGAACGTCAAGCCAGAGAGATTGAAGCTTTT GACTCTGAAAGCATGAGACTAGGTTTTAGTAATATGGTCCTTTCTAATCTCTCCCCTGAG GCATTCAGCCACAGCTACCCGGGAGCTTCTGGTTGGTCACACAACCCTACTGGGGGTCCA GGACCTCACTGGGGTCATCCCATGGGTGGCCCACCACAAGCTTGGGGCCATCCAATGCAA GGTGGACCCCAGCCATGGGGTCACCCTTCAGGGCCAATGCAAGGGGTACCTCGAGGTAGC AGTATGGGAGTCCGCAATAGCCCCCAGGCTCTGAGGCGGACAGCTTCTGGGGGACGGACA GAGCAGGGCATGAGCAGAAGCACGAGTGTCACTTCACAAATATCCAATGGGTCACACATG TCTTATACATAA |
| Restriction Sites | Please inquire |
| ACCN | NM_020791 |
| Insert Size | 3200 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_020791.1, NP_065842.1 |
| RefSeq Size | 4662 bp |
| RefSeq ORF | 3006 bp |
| Locus ID | 57551 |
| UniProt ID | Q7L7X3 |
| Protein Families | Druggable Genome, Protein Kinase |
| Protein Pathways | MAPK signaling pathway |
| Gene Summary | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC219490 | TAOK1 (Myc-DDK-tagged)-Human TAO kinase 1 (TAOK1), transcript variant 1 |
CNY 10,456.00 |
|
| RC219490L1 | Lenti-ORF clone of TAOK1 (Myc-DDK-tagged)-Human TAO kinase 1 (TAOK1), transcript variant 1 |
CNY 12,856.00 |
|
| RC219490L2 | Lenti-ORF clone of TAOK1 (mGFP-tagged)-Human TAO kinase 1 (TAOK1), transcript variant 1 |
CNY 7,600.00 |
|
| RC219490L3 | Lenti-ORF clone of TAOK1 (Myc-DDK-tagged)-Human TAO kinase 1 (TAOK1), transcript variant 1 |
CNY 7,600.00 |
|
| RC219490L4 | Lenti-ORF clone of TAOK1 (mGFP-tagged)-Human TAO kinase 1 (TAOK1), transcript variant 1 |
CNY 12,856.00 |
|
| RG219490 | TAOK1 (tGFP-tagged) - Human TAO kinase 1 (TAOK1), transcript variant 1 |
CNY 12,056.00 |
|
| SC323537 | TAOK1 (untagged)-Kinase deficient mutant (K57M) of Human TAO kinase 1 (TAOK1) |
CNY 10,464.00 |
