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ATRX (NM_138270) Human Untagged Clone
CAT＃: SC309875
ATRX (untagged)-Human alpha thalassemia/mental retardation syndrome X-linked (ATRX), transcript variant 2
CNY 47,220.00
货期*
12周
规格
Product images
经常一起买 (4)
ATRX Rabbit monoclonal antibody,clone OTIR8G1
CNY 1,999.00
CNY 3,600.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | JMS; MRX52; RAD54; RAD54L; XH2; XNP; ZNF-HX |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_138270, the custom clone sequence may differ by one or more nucleotides
ATGACCGCTGAGCCCATGAGTGAAAGCAAGTTGAATACATTGGTGCAGAAGCTTCATGAC TTCCTTGCACACTCATCAGAAGAATCTGAAGAAACAAGTTCTCCTCCACGACTTGCAATG AATCAAAACACAGATAAAATCAGTGGTTCTGGAAGTAACTCTGATATGATGGAAAACAGC AAGGAAGAGGGAACTAGCTCTTCAGAAAAATCCAAGTCTTCAGGATCGTCACGATCAAAG AGGAAACCTTCAATTGTAACAAAGTATGTAGAATCAGATGATGAAAAACCTTTGGATGAT GAAACTGTAAATGAAGATGCGTCTAATGAAAATTCAGAAAATGATATTACTATGCAGAGC TTGCCAAAAGAAGATGGGCTTCATGGGATTGTGAGCTGCACTGCTTGTGGACAACAGGTC AATCATTTTCAAAAAGATTCCATTTATAGACACCCTTCATTGCAAGTTCTTATTTGTAAG AATTGCTTTAAGTATTACATGAGTGATGATATTAGCCGTGACTCAGATGGAATGGATGAA CAATGTAGGTGGTGTGCGGAAGGTGGAAACTTGATTTGTTGTGACTTTTGCCATAATGCT TTCTGCAAGAAATGCATTCTACGCAACCTTGGTCGAAAGGAGTTGTCCACAATAATGGAT GAAAACAACCAATGGTATTGCTACATTTGTCACCCAGAGCCTTTGTTGGACTTGGTCACT GCATGTAACAGCGTATTTGAGAATTTAGAACAGTTGTTGCAGCAAAATAAGAAGAAGATA AAAGTTGACAGTGAAAAGAGTAATAAAGTATATGAACATACATCCAGATTTTCTCCAAAG AAGACTAGTTCAAATTGTAATGGAGAAGAAAAGAAATTAGATGATTCCTGTTCTGGCTCT GTAACCTACTCTTATTCCGCACTAATTGTGCCCAAAGAGATGATTAAGAAGGCAAAAAAA CTGATTGAGACCACAGCCAACATGAACTCCAGTTATGTTAAATTTTTAAAGCAGGCAACA GATAATTCAGAAATCAGTTCTGCTACAAAATTACGTCAGCTTAAGGCTTTTAAGTCTGTG TTGGCTGATATTAAGAAGGCTCATCTTGCATTGGAAGAAGACTTAAATTCCGAGTTTCGA GCGATGGATGCTGTAAACAAAGAGAAAAATACCAAAGAGCATAAAGTCATAGATGCTAAG TTTGAAACAAAAGCACGAAAAGGAGAAAAACCTTGTGCTTTGGAAAAGAAGGATATTTCA AAGTCAGAAGCTAAACTTTCAAGAAAACAGGTAGATAGTGAGCACATGCATCAGAATGTT CCAACAGAGGAACAAAGAACAAATAAAAGTACCGGTGGTGAACATAAGAAATCTGATAGA AAAGAAGAACCTCAATATGAACCTGCCAACACTTCTGAAGATTTAGACATGGATATTGTG TCTGTTCCTTCCTCAGTTCCAGAAGACATTTTTGAGAATCTTGAGACTGCTATGGAAGTT CAGAGTTCAGTTGATCATCAAGGGGATGGCAGCAGTGGAACTGAACAAGAAGTGGAGAGT TCATCTGTAAAATTAAATATTTCTTCAAAAGACAACAGAGGAGGTATTAAATCAAAAACT ACAGCTAAAGTAACAAAAGAATTATATGTTAAACTCACTCCTGTTTCCCTTTCTAATTCC CCAATTAAAGGTGCTGATTGTCAGGAAGTTCCACAAGATAAAGATGGCTATAAAAGTTGT GGTCTGAACCCCAAGTTAGAGAAATGTGGACTTGGACAGGAAAACAGTGATAATGAGCAT TTGGTTGAAAATGAAGTTTCATTACTTTTAGAGGAATCTGATCTTCGAAGATCCCCACGT GTAAAGACTACACCCTTGAGGCGACCGACAGAAACTAACCCTGTAACATCTAATTCAGAT GAAGAATGTAATGAAACAGTTAAGGAGAAACAAAAACTATCAGTTCCAGTGAGAAAAAAG GATAAGCGTAATTCTTCTGACAGTGCTATAGATAATCCTAAGCCTAATAAATTGCCAAAA TCTAAGCAATCAGAGACTGTGGATCAAAATTCAGATTCTGATGAAATGCTAGCAATCCTC AAAGAGGTGAGCAGGATGAGTCACAGTTCTTCTTCAGATACTGATATTAATGAAATTCAT ACAAACCATAAGACTTTGTATGATTTAAAGACTCAGGCGGGGAAAGATGATAAAGGAAAA AGGAAACGAAAAAGTTCTACATCTGGCTCAGATTTTGATACTAAAAAGGGCAAATCAGCT AAGAGCTCTATAATTTCTAAAAAGAAACGACAAACCCAGTCTGAGTCTTCTAATTATGAC TCAGAATTAGAAAAAGAGATAAAGAGCATGAGTAAAATTGGTGCTGCCAGAACCACCAAA AAAAGAATTCCAAATACAAAAGATTTTGACTCTTCTGAAGATGAGAAACACAGCAAAAAA GGAATGGATAATCAAGGGCACAAAAATTTGAAGACCTCACAAGAAGGATCATCTGATGAT GCTGAAAGAAAACAAGAGAGAGAGACTTTCTCTTCAGCAGAAGGCACAGTTGATAAAGAC ACGACCATCATGGAATTAAGAGATCGACTTCCTAAGAAGCAGCAAGCAAGTGCTTCCACT GATGGTGTCGATAAGCTTTCTGGGAAAGAGCAGAGTTTTACTTCTTTGGAAGTTAGAAAA GTTGCTGAAACTAAAGAAAAGAGCAAGCATCTCAAAACCAAAACATGTAAAAAAGTACAG GATGGCTTATCTGATATTGCAGAGAAATTCCTAAAGAAAGACCAGAGCGATGAAACTTCT GAAGATGATAAAAAGCAGAGCAAAAAGGGAACTGAAGAAAAAAAGAAACCTTCAGACTTT AAGAAAAAAGTAATTAAAATGGAACAACAGTATGAATCTTCATCTGATGGCACTGAAAAG TTACCTGAGCGAGAAGAAATTTGTCATTTTCCTAAGGGCATAAAACAAATTAAGAATGGA ACAACTGATGGAGAAAAGAAAAGTAAAAAAATAAGAGATAAAACTTCTAAAAAGAAGGAT GAATTATCTGATTATGCTGAGAAGTCAACAGGGAAAGGAGATAGTTGTGACTCTTCAGAG GATAAAAAGAGTAAGAATGGAGCATATGGTAGAGAGAAGAAAAGGTGCAAGTTGCTTGGA AAGAGTTCAAGGAAGAGACAAGATTGTTCATCATCTGATACTGAGAAATATTCCATGAAA GAAGATGGTTGTAACTCTTCTGATAAGAGACTGAAAAGAATAGAATTGAGGGAAAGAAGA AATTTAAGTTCAAAGAGAAATACTAAGGAAATACAAAGTGGCTCATCATCATCTGATGCT GAGGAAAGTTCTGAAGATAATAAAAAGAAGAAGCAAAGAACTTCATCTAAAAAGAAGGCA GTCATTGTCAAGGAGAAAAAGAGAAACTCCCTAAGAACAAGCACTAAAAGGAAGCAAGCT GACATTACATCCTCATCTTCTTCTGATATAGAAGATGATGATCAGAATTCTATAGGTGAG GGAAGCAGCGATGAACAGAAAATTAAGCCTGTGACTGAAAATTTAGTGCTGTCTTCACAT ACTGGATTTTGCCAATCTTCAGGAGATGAAGCCTTATCTAAATCAGTGCCTGTCACAGTG GATGATGATGATGACGACAATGATCCTGAGAATAGAATTGCCAAGAAGATGCTTTTAGAA GAAATTAAAGCCAATCTTTCCTCTGATGAGGATGGATCTTCAGATGATGAGCCAGAAGAA GGGAAAAAAAGAACTGGAAAACAAAATGAAGAAAACCCAGGAGATGAGGAAGCAAAAAAT CAAGTCAATTCTGAATCAGATTCAGATTCTGAAGAATCTAAGAAGCCAAGATACAGACAT AGGCTTTTGCGGCACAAATTGACTGTGAGTGACGGAGAATCTGGAGAAGAAAAAAAGACA AAGCCTAAAGAGCATAAAGAAGTCAAAGGCAGAAACAGAAGAAAGGTGAGCAGTGAAGAT TCAGAAGATTCTGATTTTCAGGAATCAGGAGTTAGTGAAGAAGTTAGTGAATCCGAAGAT GAACAGCGGCCCAGAACAAGGTCTGCAAAGAAAGCAGAGTTGGAAGAAAATCAGCGGAGC TATAAACAGAAAAAGAAAAGGCGACGTATTAAGGTTCAAGAAGATTCATCCAGTGAAAAC AAGAGTAATTCTGAGGAAGAAGAGGAGGAAAAAGAAGAGGAGGAGGAAGAGGAGGAGGAG GAGGAAGAGGAGGAGGAAGATGAAAATGATGATTCCAAGTCTCCTGGAAAAGGCAGAAAG AAAATTCGGAAGATTCTTAAAGATGATAAACTGAGAACAGAAACACAAAATGCTCTTAAG GAAGAGGAAGAGAGACGAAAACGTATTGCTGAGAGGGAGCGTGAGCGAGAAAAATTGAGA GAGGTGATAGAAATTGAAGATGCTTCACCCACCAAGTGTCCAATAACAACCAAGTTGGTT TTAGATGAAGATGAAGAAACCAAAGAACCTTTAGTGCAGGTTCATAGAAATATGGTTATC AAATTGAAACCCCATCAAGTAGATGGTGTTCAGTTTATGTGGGATTGCTGCTGTGAGTCT GTGAAAAAAACAAAGAAATCTCCAGGTTCAGGATGCATTCTTGCCCACTGTATGGGCCTT GGTAAGACTTTACAGGTGGTAAGTTTTCTTCATACAGTTCTTTTGTGTGACAAACTGGAT TTCAGCACGGCGTTAGTGGTTTGTCCTCTTAATACTGCTTTGAATTGGATGAATGAATTT GAGAAGTGGCAAGAGGGATTAAAAGATGATGAGAAGCTTGAGGTTTCTGAATTAGCAACT GTGAAACGTCCTCAGGAGAGAAGCTACATGCTGCAGAGGTGGCAAGAAGATGGTGGTGTT ATGATCATAGGCTATGAGATGTATAGAAATCTTGCTCAAGGAAGGAATGTGAAGAGTCGG AAACTTAAAGAAATATTTAACAAAGCTTTGGTTGATCCAGGCCCTGATTTTGTTGTTTGT GATGAAGGCCATATTCTAAAAAATGAAGCATCTGCTGTTTCTAAAGCTATGAATTCTATA CGATCAAGGAGGAGGATTATTTTAACAGGAACACCACTTCAAAATAACCTAATTGAGTAT CATTGTATGGTTAATTTTATCAAGGAAAATTTACTTGGATCCATTAAGGAGTTCAGGAAT AGATTTATAAATCCAATTCAAAATGGTCAGTGTGCAGATTCTACCATGGTAGATGTCAGA GTGATGAAAAAACGTGCTCACATTCTCTATGAGATGTTAGCTGGATGTGTTCAGAGGAAA GATTATACAGCATTAACAAAATTCTTGCCTCCAAAACACGAATATGTGTTAGCTGTGAGA ATGACTTCTATTCAGTGCAAGCTCTATCAGTACTACTTAGATCACTTAACAGGTGTGGGC AATAATAGTGAAGGTGGAAGAGGAAAGGCAGGTGCAAAGCTTTTCCAAGATTTTCAGATG TTAAGTAGAATATGGACTCATCCTTGGTGTTTGCAGCTAGACTACATTAGCAAAGAAAAT AAGGGTTATTTTGATGAAGACAGTATGGATGAATTTATAGCCTCAGATTCTGATGAAACC TCCATGAGTTTAAGCTCCGATGATTATACAAAAAAGAAGAAAAAAGGGAAAAAGGGGAAA AAAGATAGTAGCTCAAGTGGAAGTGGCAGTGACAATGATGTTGAAGTGATTAAGGTCTGG AATTCAAGATCTCGGGGAGGTGGTGAAGGAAATGTGGATGAAACAGGAAACAATCCTTCT GTTTCTTTAAAACTGGAAGAAAGTAAAGCTACTTCTTCTTCTAATCCAAGCAGCCCAGCT CCAGACTGGTACAAAGATTTTGTTACAGATGCTGATGCTGAGGTTTTAGAGCATTCTGGG AAAATGGTACTTCTCTTTGAAATTCTTCGAATGGCAGAGGAAATTGGGGATAAAGTCCTT GTTTTCAGCCAGTCCCTCATATCTCTGGACTTGATTGAAGATTTTCTTGAATTAGCTAGT AGGGAGAAGACAGAAGATAAAGATAAACCCCTTATTTATAAAGGTGAGGGGAAGTGGCTT CGAAACATTGACTATTACCGTTTAGATGGTTCCACTACTGCACAGTCAAGGAAGAAGTGG GCTGAAGAATTTAATGATGAAACTAATGTGAGAGGACGATTATTTATCATTTCTACTAAA GCAGGATCTCTAGGAATTAATCTGGTAGCTGCTAATCGAGTAATTATATTCGACGCTTCT TGGAATCCATCTTATGACATCCAGAGTATATTCAGAGTTTATCGCTTTGGACAAACTAAG CCTGTTTATGTATATAGGTTCTTAGCTCAGGGAACCATGGAAGATAAGATTTATGATCGG CAAGTAACTAAGCAGTCACTGTCTTTTCGAGTTGTTGATCAGCAGCAGGTGGAGCGTCAT TTTACTATGAATGAGCTTACTGAACTTTATACTTTTGAGCCAGACTTATTAGATGACCCT AATTCAGAAAAGAAGAAGAAGAGGGATACTCCCATGCTGCCAAAGGATACCATACTTGCA GAGCTCCTTCAGATACATAAAGAACACATTGTAGGATACCATGAACATGATTCTCTTTTG GACCACAAAGAAGAAGAAGAGTTGACTGAAGAAGAAAGAAAAGCAGCTTGGGCTGAGTAT GAAGCAGAGAAGAAGGGACTGACCATGCGTTTCAACATACCAACTGGGACCAATTTACCC CCTGTCAGTTTCAACTCTCAAACTCCTTATATTCCTTTCAATTTGGGAGCCCTGTCAGCA ATGAGTAATCAACAGCTGGAGGACCTCATTAATCAAGGAAGAGAAAAAGTTGTAGAAGCA ACAAACAGTGTGACAGCAGTGAGGATTCAACCTCTTGAGGATATAATTTCAGCTGTATGG AAGGAGAACATGAATCTCTCAGAGGCCCAAGTACAGGCGTTAGCATTAAGTAGACAAGCC AGCCAGGAGCTTGATGTTAAACGAAGAGAAGCAATCTACAATGATGTATTGACAAAACAA CAGATGTTAATCAGCTGTGTTCAGCGAATACTTATGAACAGAAGGCTCCAGCAGCAGTAC AATCAGCAGCAACAGCAACAAATGACTTATCAACAAGCAACACTGGGTCACCTCATGATG CCAAAGCCCCCAAATTTGATCATGAATCCTTCTAACTACCAGCAGATTGATATGAGAGGA ATGTATCAGCCAGTGGCTGGTGGTATGCAGCCACCACCATTACAGCGTGCACCACCCCCA ATGAGAAGCAAAAATCCAGGACCTTCCCAAGGGAAATCAATGTGA |
| Restriction Sites | Please inquire |
| ACCN | NM_138270 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_138270.1, NP_612114.1 |
| RefSeq Size | 10216 bp |
| RefSeq ORF | 7365 bp |
| Locus ID | 546 |
| UniProt ID | P46100 |
| Domains | SNF2_N, DEAD, helicase_C |
| Protein Families | Druggable Genome, Transcription Factors |
| Gene Summary | The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017] Transcript Variant: This variant (2) lacks a segment within the coding region when compared to variant 1. The translation remains in-frame, and thus results in an isoform (2) that lacks an internal segment, as compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
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