C17orf27 (RNF213) (AF318359) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Vector	pCMV6 series
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for AF318359, the custom clone sequence may differ by one or more nucleotides ATGATGAGCCACCAGTCAGTTCTGCAGATGTGTCCCCGAGCTCCTGCCGAGGGACGAAAC ACGGTGGCCCTGCTCCTAGTGCCATGTGCACGCCACGCTCCACACCTGCCATCTGCCCTT CCACCACCTGCTCCCCCAGGGGCTCCGCCTCGTGACTCACGCTCAGGCAAGTCTCCGGGC GCGAACAGCTGGCTGATGGTGACATGCTGCAGCCTGGTCACATCAGAAACCATGAGGGTG GATCTCCGGAGGTCATCGATGTGGACAGACTGCCACAGCCCTGTGAAGAGTGAAGCCACC CACAACTGTCTTTGTGTCTTTCCCGGCTGCTGCTCAGCCCTAAGCAGGGACATTGCACAC CCTGGCTTGTCATTATCTTGCTGCGCAATGAATGACTGGCACCCTGAAGCCGAAACCCTG GAATGGGCCTGCGCAGAAACCACCCAACCCGATACTATACACGACCCGATTCTATGCCCA TCGACAGCTTCACCA
Restriction Sites	Please inquire
ACCN	AF318359
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation	This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	AF318359.1, AAL55866.1
RefSeq Size	2000 bp
RefSeq ORF	498 bp
Locus ID	57674
Protein Families	Druggable Genome, Transcription Factors
Gene Summary	This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

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