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Liver Carboxylesterase 1 (CES1) (NM_001266) Human Untagged Clone
CAT＃: SC316626
CES1 (untagged)-Human carboxylesterase 1 (CES1), transcript variant 3
CNY 6,328.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ACAT; CE-1; CEH; CES2; hCE-1; HMSE; HMSE1; PCE-1; REH; SES1; TGH |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001266 |
| Insert Size | 2000 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to have a single amino acid difference from the protein associated to this reference. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001266.4, NP_001257.4 |
| RefSeq Size | 2021 bp |
| RefSeq ORF | 1701 bp |
| Locus ID | 1066 |
| UniProt ID | P23141 |
| Domains | COesterase |
| Protein Families | Druggable Genome |
| Protein Pathways | Drug metabolism - other enzymes |
| Gene Summary | This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] Transcript Variant: This variant (3) uses a different in-frame splice site at the end of two separate exons compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter by 2 aa compared to isoform a. |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Synthesis and evaluation of 2'-dihalo ribonucleotide prodrugs with activity against hepatitis C virus.
,null,
Bioorganic medicinal chemistry
,PubMed ID 31740203
[CES1]
|
|
Metabolism and Pharmacokinetics of the Anti-HCV Nucleotide Prodrug GS-6620
,Murakami, E;Wang, T;Babusis, D;Lepist, EI;Sauer, D;Park, Y;Vela, JE;Shih, R;Birkus, G;Stefanidis, D;Kim, CU;Cho, A;Ray, AS;,
Antimicrob. Agents Chemother., Jan 2014.
,PubMed ID 24419340
[CES1]
|
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC220398 | CES1 (Myc-DDK-tagged)-Human carboxylesterase 1 (CES1), transcript variant 3 |
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| RC220398L1 | Lenti ORF clone of Human carboxylesterase 1 (CES1), transcript variant 3, Myc-DDK-tagged |
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| RC220398L2 | Lenti ORF clone of Human carboxylesterase 1 (CES1), transcript variant 3, mGFP tagged |
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| RC220398L3 | Lenti ORF clone of Human carboxylesterase 1 (CES1), transcript variant 3, Myc-DDK-tagged |
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| RC220398L4 | Lenti ORF clone of Human carboxylesterase 1 (CES1), transcript variant 3, mGFP tagged |
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| RG220398 | CES1 (tGFP-tagged) - Human carboxylesterase 1 (CES1), transcript variant 3 |
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