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CCM2 (NM_031443) Human Untagged Clone
CAT＃: SC319454
CCM2 (untagged)-Human cerebral cavernous malformation 2 (CCM2), transcript variant 2
CNY 3,656.00
CNY 7,220.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | C7orf22; OSM; PP10187 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_031443.3
CCCGGGTCGAGCATGTAGCGGCTGCTGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCC
GCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGCCTGGAATT GTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAGAAAGCCCAT GAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTC GAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGTATTTAGGTCAGTTA ACGTCCATACCAGGATACCTGAATCCCTCCAGTAGGACTGAAATCCTGCATTTCATAGAC AATGCAAAGAGAGCCCACCAGCTTCCGGGACACTTGACTCAGGAGCACGATGCTGTGCTC AGCCTGTCTGCGTACAACGTCAAGCTGGCCTGGAGGGACGGGGAGGATATCATCCTCAGG GTGCCCATCCATGACATCGCCGCCGTCTCCTATGTTCGGGATGACGCTGCACACCTGGTG GTCCTGAAGACAGCCCAGGACCCAGGGATCTCCCCCAGCCAGAGTCTGTGTGCGGAAAGT TCCAGAGGCCTCAGTGCAGGCTCCCTGTCGGAGAGTGCAGTTGGGCCCGTGGAGGCATGC TGCCTGGTCATCCTGGCTGCAGAGAGCAAGGTCGCTGCGGAGGAGCTTTGCTGTCTGCTA GGCCAGGTCTTCCAGGTTGTTTACACGGAGTCCACCATCGACTTTCTGGACAGAGCGATA TTTGATGGGGCCTCTACCCCGACCCACCACCTGTCCCTGCACAGCGATGACTCTTCTACA AAAGTGGACATTAAGGAGACCTACGAGGTGGAAGCCAGCACTTTCTGCTTCCCTGAATCT GTGGATGTGGGTGGTGCATCACCCCACAGCAAGACCATCAGTGAGAGCGAGCTGAGCGCC AGCGCCACTGAGCTGCTGCAGGACTACATGCTGACGCTGCGCACCAAGCTGTCATCACAG GAGATCCAGCAGTTTGCAGCACTGCTGCACGAGTACCGCAATGGGGCCTCTATCCACGAG TTCTGCATCAACCTGCGGCAGCTCTACGGGGACAGCCGCAAGTTCCTGCTGCTTGGTCTG AGGCCCTTCATCCCTGAGAAGGACAGCCAGCACTTCGAGAACTTCCTGGAGACCATTGGC GTGAAGGATGGCCGCGGCATCATCACTGACAGCTTTGGCAGGCACCGGCGGGCCCTGAGC ACCACATCCAGTTCCACCACCAATGGGAACAGGGCCACGGGCAGCTCTGATGACCGGTCG GCACCCTCAGAGGGGGATGAGTGGGACCGCATGATCTCGGACATCAGCAGCGACATTGAG GCGCTGGGCTGCAGCATGGACCAGGACTCAGCATGATGGACAGTGGATGGGGGGGCACCC ACACCTTCCGCGCAGTCGTCATAGGCCTTCCCAGAAGGAGCTGCCCAGACCTGCGTGTCA GCCCTTGGTGGTGGCCAGGGAGAGGCGCCCGGTGCAGATGGCCCCGGGCGGCCCAGGTCC TCTACTGTGAAGGAGCAGGGAGCTGCCGAGGGACACGAGCCTCAGTGCGGGGTGGAAGGC TCTTTGCCTTGTCCACCAGGGCTCAGCCAAGCCCTGCAGTGTGTCCCCGCTCGGGGAGGG CCCGGCCGAGCGGGCAGGGAGAGCCAGTCCTGTCGGCTGGGCCCTTGGACGGCTGTCAGT TTTGCACATGATGTTCCTATTGTAACTCTCAGAGACCTTAAAAAGAAGTTTACTGCAATG TGAATAATTTAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_031443 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_031443.3, NP_113631.1 |
| RefSeq Size | 1904 bp |
| RefSeq ORF | 1335 bp |
| Locus ID | 83605 |
| UniProt ID | Q9BSQ5 |
| Gene Summary | This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009] Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a distinct start codon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. |
Documents
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| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC201418 | CCM2 (Myc-DDK-tagged)-Human cerebral cavernous malformation 2 (CCM2), transcript variant 2 |
CNY 3,656.00 |
|
| RC201418L3 | Lenti ORF clone of Human cerebral cavernous malformation 2 (CCM2), transcript variant 2, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC201418L4 | Lenti ORF clone of Human cerebral cavernous malformation 2 (CCM2), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RG201418 | CCM2 (tGFP-tagged) - Human cerebral cavernous malformation 2 (CCM2), transcript variant 2 |
CNY 5,256.00 |
|
| SC310383 | CCM2 (untagged)-Human cerebral cavernous malformation 2 (CCM2), transcript variant 2 |
CNY 7,220.00 |
