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TNFRSF1A (NM_001065) Human Untagged Clone
CAT＃: SC320382
TNFRSF1A (untagged)-Human tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A)
CNY 5,488.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_001065.2
CTCTGCTTTAATTTTCTCAGAATTCTCTGGACTGAGGCTCCAGTTCTGGCCTTTGGGGTT
CAAGATCACTGGGACCAGGCCGTGATCTCTATGCCCGAGTCTCAACCCTCAACTGTCACC CCAAGGCACTTGGGACGTCCTGGACAGACCGAGTCCCGGGAAGCCCCAGCACTGCCGCTG CCACACTGCCCTGAGCCCAAATGGGGGAGTGAGAGGCCATAGCTGTCTGGCATGGGCCTC TCCACCGTGCCTGACCTGCTGCTGCCACTGGTGCTCCTGGAGCTGTTGGTGGGAATATAC CCCTCAGGGGTTATTGGACTGGTCCCTCACCTAGGGGACAGGGAGAAGAGAGATAGTGTG TGTCCCCAAGGAAAATATATCCACCCTCAAAATAATTCGATTTGCTGTACCAAGTGCCAC AAAGGAACCTACTTGTACAATGACTGTCCAGGCCCGGGGCAGGATACGGACTGCAGGGAG TGTGAGAGCGGCTCCTTCACCGCTTCAGAAAACCACCTCAGACACTGCCTCAGCTGCTCC AAATGCCGAAAGGAAATGGGTCAGGTGGAGATCTCTTCTTGCACAGTGGACCGGGACACC GTGTGTGGCTGCAGGAAGAACCAGTACCGGCATTATTGGAGTGAAAACCTTTTCCAGTGC TTCAATTGCAGCCTCTGCCTCAATGGGACCGTGCACCTCTCCTGCCAGGAGAAACAGAAC ACCGTGTGCACCTGCCATGCAGGTTTCTTTCTAAGAGAAAACGAGTGTGTCTCCTGTAGT AACTGTAAGAAAAGCCTGGAGTGCACGAAGTTGTGCCTACCCCAGATTGAGAATGTTAAG GGCACTGAGGACTCAGGCACCACAGTGCTGTTGCCCCTGGTCATTTTCTTTGGTCTTTGC CTTTTATCCCTCCTCTTCATTGGTTTAATGTATCGCTACCAACGGTGGAAGTCCAAGCTC TACTCCATTGTTTGTGGGAAATCGACACCTGAAAAAGAGGGGGAGCTTGAAGGAACTACT ACTAAGCCCCTGGCCCCAAACCCAAGCTTCAGTCCCACTCCAGGCTTCACCCCCACCCTG GGCTTCAGTCCCGTGCCCAGTTCCACCTTCACCTCCAGCTCCACCTATACCCCCGGTGAC TGTCCCAACTTTGCGGCTCCCCGCAGAGAGGTGGCACCACCCTATCAGGGGGCTGACCCC ATCCTTGCGACAGCCCTCGCCTCCGACCCCATCCCCAACCCCCTTCAGAAGTGGGAGGAC AGCGCCCACAAGCCACAGAGCCTAGACACTGATGACCCCGCGACGCTGTACGCCGTGGTG GAGAACGTGCCCCCGTTGCGCTGGAAGGAATTCGTGCGGCGCCTAGGGCTGAGCGACCAC GAGATCGATCGGCTGGAGCTGCAGAACGGGCGCTGCCTGCGCGAGGCGCAATACAGCATG CTGGCGACCTGGAGGCGGCGCACGCCGCGGCGCGAGGCCACGCTGGAGCTGCTGGGACGC GTGCTCCGCGACATGGACCTGCTGGGCTGCCTGGAGGACATCGAGGAGGCGCTTTGCGGC CCCGCCGCCCTCCCGCCCGCGCCCAGTCTTCTCAGATGAGGCTGCGCCCCTGCGGGCAGC TCTAAGGACCGTCCTGCGAGATCGCCTTCCAACCCCACTTTTTTCTGGAAAGGAGGGGTC CTGCAGGGGCAAGCAGGAGCTAGCAGCCGCCTACTTGGTGCTAACCCCTCGATGTACATA GCTTTTCTCAGCTGCCTGCGCGCCGCCGACAGTCAGCGCTGTGCGCGCGGAGAGAGGTGC GCCGTGGGCTCAAGAGCCTGAGTGGGTGGTTTGCGAGGATGAGGGACGCTATGCCTCATG CCCGTTTTGGGTGTCCTCACCAGCAAGGCTGCTCGGGGGCCCCTGGTTCGTCCCTGAGCC TTTTTCACAGTGCATAAGCAGTTTTTTTTGTTTTTGTTTTGTTTTGTTTGTTTTTAAATC AATCATGTTACACTAATAGAAACTTGGCACTCCTGTGCCCTCTGCCTGGACAAGCACATA GCAAGCTGAACTGTCCTAAGGCAGGGGCGAGCACGGAACAATGGGGCCTTCAGCTGGAGC TGTGGACTTTTGTACATACACTAAAATTCTGAAGTTAAAGCTCTGCTCTTGGAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_001065 |
| Insert Size | 2200 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001065.2, NP_001056.1 |
| RefSeq Size | 2236 bp |
| RefSeq ORF | 1368 bp |
| Locus ID | 7132 |
| UniProt ID | P19438 |
| Domains | DEATH, TNFR |
| Protein Families | Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane |
| Protein Pathways | Adipocytokine signaling pathway, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Cytokine-cytokine receptor interaction, MAPK signaling pathway |
| Gene Summary | This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016] Transcript Variant: This variant (1) encodes the longest isoform (1). |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Cell-free methods to produce structurally intact mammalian membrane proteins
,Shinoda, T;Shinya, N;Ito, K;Ishizuka-Katsura, Y;Ohsawa, N;Terada, T;Hirata, K;Kawano, Y;Yamamoto, M;Tomita, T;Ishibashi, Y;Hirabayashi, Y;Kimura-Someya, T;Shirouzu, M;Yokoyama, S;,
Sci Rep
,PubMed ID 27465719
[TNFRSF1A]
|
|
The novel S59P mutation in the TNFRSF1A gene identified in an adult onset TNF receptor associated periodic syndrome (TRAPS) constitutively activates NF-?B pathway
,Greco, E;Aita, A;Galozzi, P;Gava, A;Sfriso, P;Negm, OH;Tighe, P;Caso, F;Navaglia, F;Dazzo, E;De Bortoli, M;Rampazzo, A;Obici, L;Donadei, S;Merlini, G;Plebani, M;Todd, I;Basso, D;Punzi, L;,
Arthritis Res. Ther.
,PubMed ID 25888769
[TNFRSF1A]
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Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC204008 | TNFRSF1A (Myc-DDK-tagged)-Human tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) |
CNY 3,656.00 |
|
| RC204008L1 | Lenti ORF clone of Human tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A), Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC204008L2 | Lenti ORF clone of Human tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A), mGFP tagged |
CNY 6,056.00 |
|
| RC204008L3 | Lenti ORF clone of Human tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A), Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC204008L4 | Lenti ORF clone of Human tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A), mGFP tagged |
CNY 6,056.00 |
|
| RG204008 | TNFRSF1A (tGFP-tagged) - Human tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) |
CNY 5,256.00 |
|
| SC127913 | TNFRSF1A (untagged)-Human tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) |
CNY 5,488.00 |
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