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YTHDC1 (NM_001031732) Human Untagged Clone
CAT＃: SC324231
YTHDC1 (untagged)-Human YTH domain containing 1 (YTHDC1), transcript variant 1
CNY 5,336.00
CNY 7,220.00
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热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | YT521; YT521-B |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_001031732.2
CGCCGTCGCCATCTGTTTCCCTTCCCTCCCCCATACCTAGCCCGAGTCTGAGCCCTAACG
AGAAGGCTGGGCCTAGGCCGCTGGATGCTGGAGTGAAAGGAAGGGAGAAAGGGAAAAAGC GGGAAGAGTCGAGAAGGCTGAGTGTTAAGAGGCCAAGTGCGACGCGCGTATCCGGGCAGA CGGACTGACGGACGGGCCCGTGCTTCTGCCGCGGCTGCGGCGCCCGCGCGAGTCGCGTCT AAGCGGCGGCGGCGGTGGCAGCGGCGGAAACCGAAGGGGAGCCATGGCGGCTGACAGTCG GGAGGAGAAAGATGGAGAACTTAATGTTCTGGATGATATTTTAACTGAAGTACCAGAACA AGATGATGAACTGTATAATCCAGAGAGTGAACAAGATAAAAATGAGAAAAAGGGATCAAA AAGAAAAAGTGATCGAATGGAATCTACTGATACCAAACGACAAAAGCCTTCTGTCCATTC AAGACAACTGGTTTCTAAGCCACTGAGCTCATCTGTTAGCAATAACAAAAGAATAGTTAG TACAAAAGGAAAGTCAGCCACAGAGTATAAAAATGAGGAATATCAAAGATCTGAAAGAAA CAAGCGTCTAGATGCTGATCGGAAAATTCGTCTATCAAGTAGTGCCTCCAGAGAACCTTA TAAGAATCAACCTGAAAAAACCTGTGTCCGGAAAAGGGATCCTGAAAGGAGGGCCAAATC TCCTACGCCAGATGGTTCTGAGAGAATTGGGCTTGAAGTGGATAGACGTGCAAGCAGATC CAGCCAGTCTTCTAAGGAAGAAGTGAACTCTGAAGAATATGGCTCTGACCATGAGACTGG CAGCAGTGGTTCTTCTGATGAGCAAGGGAACAACACTGAGAATGAGGAGGAAGGAGTGGA AGAAGATGTGGAGGAAGATGAAGAAGTAGAAGAAGATGCAGAAGAAGATGAAGAGGTGGA TGAAGATGGAGAGGAGGAGGAGGAAGAGGAGGAGGAGGAAGAGGAGGAGGAGGAGGAGGA AGAAGAAGAATATGAACAGGATGAGAGAGACCAGAAAGAGGAGGGAAATGATTATGACAC TCGAAGTGAGGCCAGTGACTCTGGTTCTGAATCTGTTTCCTTCACAGATGGGTCTGTCAG ATCTGGTTCAGGCACAGATGGATCAGATGAGAAAAAGAAGGAAAGGAAGAGAGCTAGAGG CATATCTCCAATTGTTTTTGATAGAAGTGGAAGCTCTGCATCAGAGTCATATGCAGGTTC AGAAAAGAAGCATGAGAAATTATCATCTTCCGTTCGTGCTGTCCGAAAAGATCAAACCAG TAAACTCAAATATGTGCTTCAAGATGCAAGATTTTTCCTCATAAAGAGTAACAACCATGA GAATGTGTCTCTTGCCAAAGCGAAGGGTGTATGGTCCACGCTCCCTGTAAATGAGAAGAA ATTAAATCTTGCATTTAGATCTGCAAGGAGTGTTATCTTAATATTTTCTGTCAGAGAGAG TGGAAAATTTCAAGGGTTTGCAAGACTTTCTTCAGAATCACATCACGGAGGATCTCCTAT ACACTGGGTGCTTCCAGCAGGAATGAGTGCTAAAATGCTGGGAGGTGTCTTTAAAATTGA CTGGATTTGCAGGCGTGAATTACCCTTCACTAAGTCGGCTCATCTCACCAATCCTTGGAA TGAACATAAACCAGTAAAGATCGGACGTGATGGACAGGAAATTGAACTTGAATGTGGAAC CCAGCTTTGTCTTCTGTTTCCCCCCGATGAAAGTATTGACTTGTATCAGGTCATTCATAA AATGCGTCACAAGAGAAGAATGCATTCTCAGCCCCGATCACGAGGACGTCCATCCCGTCG AGAACCAGTCCGGGATGTGGGAAGGCGTCGACCAGAAGATTATGATATTCATAACAGCAG AAAGAAACCAAGGATTGACTATCCCCCTGAGTTTCACCAGAGACCAGGGTATTTAAAGGA TCCACGATACCAGGAAGTGGACAGACGATTTTCAGGAGTTCGCCGAGATGTGTTTTTAAA TGGGTCCTACAATGATTATGTGAGGGAATTTCATAACATGGGACCACCACCACCTTGGCA AGGAATGCCCCCTTACCCAGGAATGGAACAACCTCCACACCATCCTTACTATCAGCACCA TGCTCCACCTCCTCAAGCTCATCCCCCTTACTCAGGACATCATCCAGTACCACATGAAGC AAGATACAGAGATAAACGAGTACATGATTATGATATGAGGGTGGATGATTTCCTTCGTCG CACACAAGCTGTTGTCAGTGGCCGGAGAAGTAGACCCCGTGAAAGAGACCGGGAACGAGA GCGAGACCGCCCTAGAGATAACAGACGAGACAGAGAGCGAGATAGAGGACGTGATAGAGA AAGAGAAAGAGAGCGATTATGTGATCGAGACAGAGACCGAGGGGAGAGAGGTCGATATAG AAGATAATGGGCTTTTGGAAGCACTGATTGTTTAAAGATACAAAAAATCTTGTATTTTTT TTTTGTGTGTGTTTACAAGTAGTAAATTTATTTTCAGCTGTCTGCCTATGAAGTTCATTG TGTAGAAGGATTTATTATGACCCCCTTTGTTCCAAGCATGCAGTATCATAAGAACTGGAA AAACTCAAATCCGCCAAAAATCCACAGCTGACAGTTGAATTGACACTTTTATTGGGGCAG AATGGAACAGTCCAAGAATGTAGATACTGATTCTTTCTCCATAAATGTTCTTATAGTGTG TTCATCCTAGAGTTATTTTTTTGTTTGTTTTTTTCCTTTTTGGATCTTGATTGATAACTG CCATGATATTTTGCTTTGATGTGTTTCTACATGTAGTTGCACACGGTTCAGTAAAAATAA TGCTGCTATCGAGTATGCAAATATTGAAGTATGATGGTTTGACTGTATGGCAGTGTTGTA GCAGCCTCTTGTTTTTTTCCCCATTGCCTCTTTTTTTAAAAAACTTATAAAGTCACTTTT TATTTTTCCTCAGTCTTCAATGACGAGAGCAATATTAAGAAGACATTGCTATCTAATTTT TAATCTTTTTAAATGAAAAATTCCTATGTTCAGTAGCGTGGTTGATGCTATTGTTTAGCC TTCCCCTCCAAATTGTATACATTGGCTTGGAATGTTCACAACTTGCGTGCGTGGCAGCGG AAGACGATTCCCATATTCTACATTGCTACTGTTTTGTATAAAATAAATTGGTAAAGATTG AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | ECoRI-NOT |
| ACCN | NM_001031732 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001031732.2, NP_001026902.1 |
| RefSeq Size | 6249 bp |
| RefSeq ORF | 2184 bp |
| Locus ID | 91746 |
| UniProt ID | Q96MU7 |
| Gene Summary | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) encodes isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC207931 | YTHDC1 (Myc-DDK-tagged)-Human YTH domain containing 1 (YTHDC1), transcript variant 1 |
CNY 7,984.00 |
|
| RC207931L1 | Lenti-ORF clone of YTHDC1 (Myc-DDK-tagged)-Human YTH domain containing 1 (YTHDC1), transcript variant 1 |
CNY 5,890.00 |
|
| RC207931L2 | Lenti-ORF clone of YTHDC1 (mGFP-tagged)-Human YTH domain containing 1 (YTHDC1), transcript variant 1 |
CNY 10,384.00 |
|
| RC207931L3 | Lenti-ORF clone of YTHDC1 (Myc-DDK-tagged)-Human YTH domain containing 1 (YTHDC1), transcript variant 1 |
CNY 5,890.00 |
|
| RC207931L4 | Lenti-ORF clone of YTHDC1 (mGFP-tagged)-Human YTH domain containing 1 (YTHDC1), transcript variant 1 |
CNY 10,384.00 |
|
| RG207931 | YTHDC1 (tGFP-tagged) - Human YTH domain containing 1 (YTHDC1), transcript variant 1 |
CNY 9,584.00 |
