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YTHDC1 (NM_001031732) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC207931L1V
- LentiORF®
-
Lenti ORF particles, YTHDC1 (Myc-DDK-tagged)-Human YTH domain containing 1 (YTHDC1), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 8,930.00
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| Product Data | |
| Product Name | YTHDC1 (NM_001031732) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | YT521; YT521-B |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_001031732 |
| ORF Size | 2181 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC207931).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001031732.2 |
| RefSeq Size | 6249 bp |
| RefSeq ORF | 2184 bp |
| Locus ID | 91746 |
| MW | 84.5 kDa |
| Gene Summary | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity).[UniProtKB/Swiss-Prot Function] |
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