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TGF beta 2 (TGFB2) (NM_001135599) Human Untagged Clone
CAT＃: SC325930
TGFB2 (untagged)-Human transforming growth factor, beta 2 (TGFB2), transcript variant 1
CNY 5,488.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | G-TSF; LDS4; TGF-beta2 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_001135599 edited
GCCCCGGGACCTTTTCATCTCTTCCCTTTTGGCCGGAGGAGCCGAGTTCAGATCCGCCAC TCCGCACCCGAGACTGACACACTGAACTCCACTTCCTCCTCTTAAATTTATTTCTACTTA ATAGCCACTCGTCTCTTTTTTTTCCCCATCTCATTGCTCCAAGAATTTTTTTCTTCTTAC TCGCCAAAGTCAGGGTTCCCTCTGCCCGTCCCGTATTAATATTTCCACTTTTGGAACTAC TGGCCTTTTCTTTTTAAAGGAATTCAAGCAGGATACGTTTTTCTGTTGGGCATTGACTAG ATTGTTTGCAAAAGTTTCGCATCAAAAACAACAACAACAAAAAACCAAACAACTCTCCTT GATCTATACTTTGAGAATTGTTGATTTCTTTTTTTTATTCTGACTTTTAAAAACAACTTT TTTTTCCACTTTTTTAAAAAATGCACTACTGTGTGCTGAGCGCTTTTCTGATCCTGCATC TGGTCACGGTCGCGCTCAGCCTGTCTACCTGCAGCACACTCGATATGGACCAGTTCATGC GCAAGAGGATCGAGGCGATCCGCGGGCAGATCCTGAGCAAGCTGAAGCTCACCAGTCCCC CAGAAGACTATCCTGAGCCCGAGGAAGTCCCCCCGGAGGTGATTTCCATCTACAACAGCA CCAGGGACTTGCTCCAGGAGAAGGCGAGCCGGAGGGCGGCCGCCTGCGAGCGCGAGAGGA GCGACGAAGAGTACTACGCCAAGGAGGTTTACAAAATAGACATGCCGCCCTTCTTCCCCT CCGAAACTGTCTGCCCAGTTGTTACAACACCCTCTGGCTCAGTGGGCAGCTTGTGCTCCA GACAGTCCCAGGTGCTCTGTGGGTACCTTGATGCCATCCCGCCCACTTTCTACAGACCCT ACTTCAGAATTGTTCGATTTGACGTCTCAGCAATGGAGAAGAATGCTTCCAATTTGGTGA AAGCAGAGTTCAGAGTCTTTCGTTTGCAGAACCCAAAAGCCAGAGTGCCTGAACAACGGA TTGAGCTATATCAGATTCTCAAGTCCAAAGATTTAACATCTCCAACCCAGCGCTACATCG ACAGCAAAGTTGTGAAAACAAGAGCAGAAGGCGAATGGCTCTCCTTCGATGTAACTGATG CTGTTCATGAATGGCTTCACCATAAAGACAGGAACCTGGGATTTAAAATAAGCTTACACT GTCCCTGCTGCACTTTTGTACCATCTAATAATTACATCATCCCAAATAAAAGTGAAGAAC TAGAAGCAAGATTTGCAGGTATTGATGGCACCTCCACATATACCAGTGGTGATCAGAAAA CTATAAAGTCCACTAGGAAAAAAAACAGTGGGAAGACCCCACATCTCCTGCTAATGTTAT TGCCCTCCTACAGACTTGAGTCACAACAGACCAACCGGCGGAAGAAGCGTGCTTTGGATG CGGCCTATTGCTTTAGAAATGTGCAGGATAATTGCTGCCTACGTCCACTTTACATTGATT TCAAGAGGGATCTAGGGTGGAAATGGATACACGAACCCAAAGGGTACAATGCCAACTTCT GTGCTGGAGCATGCCCGTATTTATGGAGTTCAGACACTCAGCACAGCAGGGTCCTGAGCT TATATAATACCATAAATCCAGAAGCATCTGCTTCTCCTTGCTGCGTGTCCCAAGATTTAG AACCTCTAACCATTCTCTACTACATTGGCAAAACACCCAAGATTGAACAGCTTTCTAATA TGATTGTAAAGTCTTGCAAATGCAGCTAAAATTCTTGGAAAAGTGGCAAGACCAAAATGA CAATGATGATGATAATGATGATGACGACGACAACGATGATGCTTGTAACAAGAAAACATA AGAGAGCCTTGGTTCATCAGTGTTAAAAAATTTTTGAAAAGGCGGTACTAGTTCAGACAC TTTGGAAGTTTGTGTTCTGTTTGTTAAAACTGGCATCTGACACAAAAAAAGTTGAAGGCC TTATTCTACATTTCACCTACTTTGTAAGTGAGAGAGACAAGAAGCAAATTTTTTTTAAAG AAAAAAATAAACACTGGAAGAATTTATTAGTGTTAATTATGTGAACAACGACAACAACAA CAACAACAACAAACAGGAAAATCCCATTAAGTGGAGTTGCTGTACGTACCGTTCCTATCC CGCGCCTCACTTGATTTTTCTGTATTGCTATGCAATAGGCACCCTTCCCATTCTTACTCT TAGAGTTAACAGTGAGTTATTTATTGTGTGTTACTATATAATGAACGTTTCATTGCCCTT GGAAAATAAAACAGGTGTATAAAGTGGAGACCAAATACTTTGCCAGAAACTCATGGATGG CTTAAGGAACTTGAACTCAAACGAGCCAGAAAAAAAGAGGTCATATTAATGGGATGAAAA CCCAAGTGAGTTATTATATGACCGAGAAAGTCTGCATTAAGATAAAGACCCTGAAAACAC ATGTTATGTATCAGCTGCCTAAGGAAGCTTCTTGTAAGGTCCAAAAACTAAAAAGACTGT TAATAAAAGAAACTTTCAGTCAGAATAAGTCTGTAAGTTTTTTTTTTTCTTTTTAATTGT AAATGGTTCTTTGTCAGTTTAGTAAACCAGTGAAATGTTGAAATGTTTTGACATGTACTG GTCAAACTTCAGACCTTAAAATATTGCTGTATAGCTATGCTATAGGTTTTTTCCTTTGTT TTGGTATATGTAACCATACCTATATTATTAAAATAGATGGATATAGAAGCCAGCATAATT GAAAACACATCTGCAGATCTCTTTTGCAAACTATTAAATCAAAACATTAACTACTTTATG TGTAATGTGTAAATTTTTACCATATTTTTTATATTCTGTAATAATGTCAACTATGATTTA GATTGACTTAAATTTGGGCTCTTTTTAATGATCACTCACAAATGTATGTTTCTTTTAGCT GGCCAGTACTTTTGAGTAAAGCCCCTATAGTTTGACTTGCACTACAAATGCATTTTTTTT TTAATAACATTTGCCCTACTTGTGCTTTGTGTTTCTTTCATTATTATGACATAAGCTACC TGGGTCCACTTGTCTTTTCTTTTTTTTGTTTCACAGAAAAGATGGGTTCGAGTTCAGTGG TCTTCATCTTCCAAGCATCATTACTAACCAAGTCAGACGTTAACAAATTTTTATGTTAGG AAAAGGAGGAATGTTATAGATACATAGAAAATTGAAGTAAAATGTTTTCATTTTAGCAAG GATTTAGGGTTCTAACTAAAACTCAGAATCTTTATTGAGTTAAGAAAAGTTTCTCTACCT TGGTTTAATCAATATTTTTGTAAAATCCTATTGTTATTACAAAGAGGACACTTCATAGGA AACATCTTTTTCTTTAGTCAGGTTTTTAATATTCAGGGGGAAATTGAAAGATATATATTT TAGTCGATTTTTCAAAAGGGGAAAAAAGTCCAGGTCAGCATAAGTCATTTTGTGTATTTC ACTGAAGTTATAAGGTTTTTATAAATGTTCTTTGAAGGGGAAAAGGCACAAGCCAATTTT TCCTATGATCAAAAAATTCTTTCTTTCCTCTGAGTGAGAGTTATCTATATCTGAGGCTAA AGTTTACCTTGCTTTAATAAATAATTTGCCACATCATTGCAGAAGAGGTATCCTCATGCT GGGGTTAATAGAATATGTCAGTTTATCACTTGTCGCTTATTTAGCTTTAAAATAAAAATT AATAGGCAAAGCAATGGAATATTTGCAGTTTCACCTAAAGAGCAGCATAAGGAGGCGGGA ATCCAAAGTGAAGTTGTTTGATATGGTCTACTTCTTTTTTGGAATTTCCTGACCATTAAT TAAAGAATTGGATTTGCAAGTTTGAAAACTGGAAAAGCAAGAGATGGGATGCCATAATAG TAAACAGCCCTTGTGTTGGATGTAACCCAATCCCAGATTTGAGTGTGTGTTGATTATTTT TTTGTCTTCCACTTTTCTATTATGTGTAAATCACTTTTATTTCTGCAGACATTTTCCTCT CAGATAGGATGACATTTTGTTTTGTATTATTTTGTCTTTCCTCATGAATGCACTGATAAT ATTTTAAATGCTCTATTTTAAGATCTCTTGAATCTGTTTTTTTTTTTTTTAATTTGGGGG TTCTGTAAGGTCTTTATTTCCCATAAGTAAATATTGCCATGGGAGGGGGGTGGAGGTGGC AAGGAAGGGGTGAAGTGCTAGTATGCAAGTGGGCAGCAATTATTTTTGTGTTAATCAGCA GTACAATTTGATCGTTGGCATGGTTAAAAAATGGAATATAAGATTAGCTGTTTTGTATTT TGATGACCAATTACGCTGTATTTTAACACGATGTATGTCTGTTTTTGTGGTGCTCTAGTG GTAAATAAATTATTTCGATGATAAAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_001135599 |
| Insert Size | 4400 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | The ORF of this clone has been fully sequenced and found to be a perfect match to NM_001135599.1 |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001135599.1, NP_001129071.1 |
| RefSeq Size | 5251 bp |
| RefSeq ORF | 1329 bp |
| Locus ID | 7042 |
| UniProt ID | P61812 |
| Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
| Protein Pathways | Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Pancreatic cancer, Pathways in cancer, Renal cell carcinoma, TGF-beta signaling pathway |
| Gene Summary | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016] Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). This isoform (1) may undergo proteolytic processing similar to isoform 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC227984 | TGFB2 (Myc-DDK-tagged)-Human transforming growth factor, beta 2 (TGFB2), transcript variant 1 |
CNY 5,488.00 |
|
| RC227984L1 | Lenti ORF clone of Human transforming growth factor, beta 2 (TGFB2), transcript variant 1, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC227984L2 | Lenti ORF clone of Human transforming growth factor, beta 2 (TGFB2), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC227984L3 | Lenti ORF clone of Human transforming growth factor, beta 2 (TGFB2), transcript variant 1, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC227984L4 | Lenti ORF clone of Human transforming growth factor, beta 2 (TGFB2), transcript variant 1, mGFP tagged |
CNY 7,888.00 |
|
| RG227984 | TGFB2 (tGFP-tagged) - Human transforming growth factor, beta 2 (TGFB2), transcript variant 1 |
CNY 7,088.00 |
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