FCP1 (CTDP1) (NM_001202504) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	CCFDN; FCP1
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC331462 representing NM_001202504. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGAAAGGCCTGTGTGCTGAATGTGGCCAAGACCTCACCCAGTTGCAGAGTAAGAACGGGAAGCAGCAG GTGCCGCTGTCCACGGCGACCGTGTCCATGGTGCACAGCGTGCCGGAGTTGATGGTGAGCTCCGAGCAA GCTGAACAGCTGGGAAGAGAAGACCAGCAGCGACTGCACCGAAACCGGAAGCTGGTGCTCATGGTGGAC TTGGACCAGACGTTGATTCACACAACCGAGCAGCACTGTCAGCAGATGTCGAATAAAGGCATCTTTCAC TTCCAGCTGGGCCGGGGTGAGCCCATGCTGCACACGCGCCTGCGTCCACACTGCAAGGACTTCCTGGAG AAGATCGCCAAGCTGTACGAGCTGCACGTCTTCACCTTCGGCAGCCGGCTGTACGCACACACCATCGCA GGCTTTTTAGACCCCGAGAAGAAGCTTTTTTCTCACCGAATATTATCAAGGGATGAATGTATTGACCCA TTTTCTAAAACGGGAAACCTTAGAAATCTCTTTCCTTGTGGAGACTCAATGGTTTGCATTATTGATGAT CGAGAAGATGTCTGGAAGTTTGCCCCCAATCTGATAACTGTGAAGAAATATGTATACTTCCAGGGCACG GGTGATATGAATGCGCCCCCTGGGTCCCGAGAATCTCAGACGAGAAAGAAAGTAAATCATTCTCGAGGC ACTGAGGTCTCAGAGCCATCTCCGCCCGTGAGAGACCCTGAGGGGGTAACGCAGGCCCCTGGAGTGGAG CCCAGCAATGGCCTGGAGAAGCCTGCACGGGAGCTGAACGGCAGCGAGGCCGCCACCCCGCGGGACTCA CCCCGCCCCGGGAAGCCAGACGAGAGGGACATCTGGCCCCCTGCCCAGGCCCCCACCAGCAGCCAAGAG CTGGCAGGCGCTCCTGAGCCCCAGGGATCCTGTGCGCAGGGTGGCCGGGTGGCACCGGGACAGCGGCCT GCCCAGGGTGCCACGGGCACTGACCTGGACTTTGACTTATCCAGCGACAGCGAGAGCAGCAGTGAGTCC GAGGGCACGAAGTCCTCCTCCTCCGCCTCTGATGGCGAAAGCGAGGGGAAAAGAGGCCGGCAGAAGCCG AAGGCTGCCCCAGAGGGAGCCGGGGCGCTGGCACAGGGCAGTTCCCTGGAGCCGGGGCGGCCTGCAGCA CCGAGTCTCCCCGGAGAGGCCGAGCCTGGCGCGCATGCCCCGGACAAGGAGCCTGAGCTGGGTGGGCAG GAGGAGGGCGAGCGGGATGGCCTCTGCGGCCTGGGCAACGGCTGTGCCGACAGGAAGGAGGCGGAGACC GAGTCACAGAACAGCGAGCTGTCGGGGGTCACTGCGGGTGAGTCCCTGGACCAGAGCATGGAGGAGGAG GAGGAGGAGGACACGGATGAGGATGACCACCTCATCTACCTGGAGGAGATCCTGGTCCGTGTACACACT GACTACTATGCCAAGTATGACCGCTACCTCAACAAGGAGATCGAGGAGGCGCCGGACATCCGCAAGATC GTGCCGGAGCTCAAGAGCAAGGTGCTGGCAGACGTGGCCATAATTTTCAGTGGGCTACACCCGACAAAC TTCCCGATAGAGAAGACGCGGGAGCATTACCACGCCACGGCGCTGGGAGCGAAGATCCTCACTCGGCTG GTGCTGAGCCCCGACGCCCCTGACAGGGCCACGCACCTGATCGCCGCGCGAGCTGGCACAGAGAAGGTG CTGCAGGCACAGGAGTGCGGACACCTGCACGTGGTCAACCCTGACTGGCTGTGGAGCTGCCTGGAGCGC TGGGACAAGGTGGAGGAGCAGCTCTTCCCGCTCAGGGACGATCACACCAAGGCACAGAGGGAGAACAGC CCTGCGGCCTTTCCCGACCGGGAGGGTGTGCCCCCCACCGCCTTGTTCCACCCGATGCCGGTTCTTCCC AAGGCCCAGCCTGGCCCCGAGGTTCGGATCTACGACTCCAACACGGGGAAGCTCATCAGGACGGGCGCC CGGGGGCCCCCAGCACCCTCCAGCTCCCTACCCATCCGCCAGGAGCCCTCTTCCTTCAGAGCGGTTCCG CCACCCCAGCCGCAGATGTTTGGTGAAGAGCTGCCTGACGCTCAGGACGGAGAGCAGCCTGGCCCTTCT AGAAGAAAGCGACAGCCCAGTATGTCTGAGACAATGCCGCTGTACACTCTTTGTAAGGAGGATTTAGAG AGTATGGACAAAGAGGTGGACGACATCCTTGGAGAAGGCAGCGACGACAGCGACAGCGAGAAGAGGAGG CCTGAGGAGCAGGAGGAGGAGCCCCAGCCCCGGAAGCCAGGGACCCGCAGGGAGCGGACGCTCGGGGCA CCTGCGTCCAGCGAGAGGAGCGCGGCAGGGGGCCGGGGGCCCAGAGGCCACAAGAGGAAGCTGAATGAA GAGGACGCCGCCAGCGAGTCCAGCAGGGAGTCCAGCAACGAGGATGAGGGCAGCAGCTCCGAGGCCGAC GAGATGGCCAAGGCGCTGGAGGCGGAGCTCAACGACCTCATGTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001202504
Insert Size	2529 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_001202504.1
RefSeq Size	3392 bp
RefSeq ORF	2529 bp
Locus ID	9150
UniProt ID	Q9Y5B0
Protein Families	Druggable Genome, Phosphatase, Transcription Factors
MW	92.4 kDa
Gene Summary	This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011] Transcript Variant: This variant (3) contains an alternate 5' terminal exon compared to variant 1, resulting in translation initiation from an in-frame downstream AUG, and a shorter isoform (3, also known as FCP1a) compared to isoform 1.

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