KIFAP3 (NM_001204517) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP; Smg-GDS
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC331600 representing NM_001204517. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGGGGACCCCATGTTGGGAGAACGAAAAGAATGTCAAAAAATCATTCGACTTAAGAGTCTCAATGCC AACACAGATATAACTTCCCTGGCAAGGAAGGTGGTTGAAGAATGTAAACTCATTCATCCTTCAAAACTA AATGAGGTAGAACAGCTGTTGTACTATCTACAGAACCGCCGTGATTCATTGTCAGGAAAAGAGAAAAAA GAAAAATCAAGCAAGCCTAAAGATCCACCTCCTTTTGAAGGAATGGAGATTGATGAAGTTGCTAACATT AATGACATGGATGAATATATTGAGTTATTATATGAAGATATTCCTGACAAAGTTCGGGGTTCTGCTTTG ATCCTGCAGCTTGCTCGAAATCCTGATAACTTGGAAGAACTACTATTGAATGAAACTGCCCTTGGTGCA TTAGCAAGGGTCCTGAGAGAAGACTGGAAGCAAAGTGTCGAGTTAGCTACAAACATAATTTACATCTTT TTTTGTTTCTCCAGCTTTTCTCAATTTCATGGACTTATTACTCACTATAAAATTGGAGCTCTGTGTATG AATATTATTGATCATGAGTTAAAAAGACATGAGCTTTGGCAAGAAGAACTCTCAAAGAAGAAGAAAGCT GTTGATGAAGACCCTGAAAACCAAACCTTGAGAAAGGATTATGAAAAAACCTTTAAAAAGTACCAGGGG CTTGTGGTAAAACAGGAACAGCTATTACGAGTTGCTCTTTATTTGCTTCTGAATCTTGCTGAGGATACT CGTACCGAACTGAAAATGAGGAACAAGAACATAGTTCACATGTTGGTGAAAGCCCTTGATCGGGACAAT TTTGAGCTGCTAATTTTAGTTGTGTCATTCTTGAAGAAACTCAGCATTTTTATGGAGAATAAAAATGAT ATGGTGGAAATGGATATTGTTGAAAAACTGGTGAAAATGATACCTTGTGAGCATGAAGACCTGCTGAAT ATCACCCTCCGACTTTTACTAAACCTATCCTTTGACACAGGACTGAGGAATAAGATGGTACAAGTTGGA CTGCTTCCCAAGCTCACTGCACTCCTAGGCAATGACAACTACAAACAAATAGCAATGTGTGTTCTTTAC CACATAAGCATGGATGACCGCTTTAAATCAATGTTTGCATACACTGACTGTATACCACAGTTAATGAAG ATGCTGTTTGAATGTTCAGATGAACGAATTGACTTGGAACTCATTTCTTTCTGCATTAATCTTGCTGCT AACAAAAGAAATGTACAGCTTATCTGTGAAGGAAATGGGCTGAAGATGCTCATGAAGAGGGCTCTGAAG TTTAAGGATCCATTGCTGATGAAAATGATTAGAAACATTTCTCAGCATGATGGACCAACTAAAAATCTG TTTATTGATTATGTTGGGGACCTTGCAGCCCAGATCTCTAATGATGAAGAAGAGGAGTTTGTGATTGAA TGTTTGGGAACTCTTGCAAACTTGACCATTCCAGACTTAGACTGGGAATTGGTTCTTAAAGAATATAAG TTGGTTCCATACCTCAAGGATAAACTAAAACCAGGTGCTGCAGAAGATGATCTTGTTTTAGAAGTGGTT ATAATGATTGGAACTGTATCCATGGATGACTCTTGTGCTGCATTGCTAGCCAAATCTGGCATAATCCCT GCACTCATTGAATTGCTAAATGCTCAACAAGAAGATGATGAATTTGTGTGTCAGATAATTTATGTCTTC TACCAGATGGTTTTCCACCAAGCCACAAGAGACGTCATAATCAAGGAAACACAGGCTCCAGCATATCTC ATAGACCTAATGCATGATAAGAATAATGAAATCCGAAAGGTCTGTGATAATACATTAGATATTATAGCG GAATATGATGAAGAATGGGCTAAGAAAATTCAGAGTGAAAAGTTTCGCTGGCATAACTCTCAGTGGCTG GAGATGGTAGAGAGTCGTCAGATGGATGAGAGTGAGCAGTACTTGTATGGTGATGATCGAATTGAGCCA TACATTCATGAAGGAGATATTCTCGAAAGACCTGACCTTTTCTACAACTCAGATGGATTAATTGCCTCT GAAGGAGCCATAAGTCCCGATTTCTTCAATGATTACCACCTTCAAAATGGAGATGTTGTTGGGCAGCAT TCATTTCCTGGCAGCCTTGGAATGGATGGCTTTGGCCAACCAGTTGGCATTCTTGGACGCCCTGCCACA GCATATGGATTCCGCCCTGATGAACCTTACTACTATGGCTATGGATCTTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001204517
Insert Size	2259 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001204517.1
RefSeq Size	4120 bp
RefSeq ORF	2259 bp
Locus ID	22920
UniProt ID	Q92845
Protein Families	Druggable Genome
MW	86.7 kDa
Gene Summary	The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.

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