PTPRB (NM_001206972) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC331725 representing NM_001206972. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGCTGAGCCATGGAGCCGGGTTGGCCTTGTGGATCACACTGAGCCTGCTGCAGACTGGACTGGCGGAG CCAGAGAGATGTAACTTCACCCTGGCGGAGTCCAAGGCCTCCAGCCATTCTGTGTCTATCCAGTGGAGA ATTTTGGGCTCACCCTGTAACTTTAGCCTCATCTATAGCAGTGACACCCTGGGGGCCGCGTTGTGCCCT ACCTTTCGGATAGACAACACCACATACGGATGTAACCTTCAAGATTTACAAGCAGGAACCATCTATAAC TTCAGGATTATTTCTCTGGATGAAGAGAGAACAGTGGTCTTGCAAACAGATCCTTTACCTCCTGCTAGG TTTGGAGTCAGTAAAGAGAAGACGACTTCAACCAGCTTGCATGTTTGGTGGACTCCTTCTTCCGGAAAA GTCACCTCATATGAGGTGCAATTATTTGATGAAAATAACCAAAAGATACAGGGGGTTCAAATTCAAGAA AGTACTTCATGGAATGAATACACTTTTTTCAATCTCACTGCTGGTAGTAAATACAATATTGCCATCACA GCTGTTTCTGGAGGAAAACGTTCTTTTTCAGTTTATACCAATGGATCAACAGTGCCATCTCCAGTGAAA GATATTGGTATTTCCACAAAAGCCAATTCTCTCCTGATTTCCTGGTCCCATGGTTCTGGGAATGTGGAA CGATACCGGCTGATGCTAATGGATAAAGGGATCCTAGTTCATGGCGGTGTTGTGGACAAACATGCTACT TCCTATGCTTTTCACGGGCTGACCCCTGGCTACCTCTACAACCTCACTGTTATGACTGAGGCTGCAGGG CTGCAAAACTACAGGTGGAAACTAGTCAGGACAGCCCCCATGGAAGTCTCAAATCTGAAGGTGACAAAT GATGGCAGTTTGACCTCTCTAAAAGTCAAATGGCAAAGACCTCCTGGAAATGTGGATTCTTACAATATC ACCCTGTCTCACAAAGGGACCATCAAGGAATCCAGAGTATTAGCACCTTGGATTACTGAAACTCACTTT AAAGAGTTAGTCCCCGGTCGACTTTATCAAGTTACTGTCAGCTGTGTCTCTGGTGAACTGTCTGCTCAG AAGATGGCAGTGGGCAGAACATTTCCAGACAAAGTTGCAAACCTGGAGGCAAACAATAATGGCAGGATG AGGTCTCTTGTAGTGAGCTGGTCGCCCCCTGCTGGAGACTGGGAGCAGTATCGGATCCTACTCTTCAAT GATTCTGTGGTGCTGCTCAACATCACTGTGGGAAAGGAAGAAACACAGTATGTCATGGATGACACGGGG CTCGTACCGGGAAGACAGTATGAGGTGGAAGTCATTGTTGAGAGTGGAAATTTGAAGAATTCTGAGCGT TGCCAAGGCAGGACAGTCCCCCTGGCTGTCCTCCAGCTTCGTGTCAAACATGCCAATGAAACCTCACTG AGTATCATGTGGCAGACCCCTGTAGCAGAATGGGAGAAATACATCATTTCCCTAGCTGACAGAGACCTC TTACTGATCCACAAGTCACTCTCCAAAGATGCCAAAGAATTCACTTTTACTGACCTGGTGCCTGGACGA AAATACATGGCTACAGTCACCAGTATTAGTGGAGACTTAAAAAATTCCTCTTCAGTAAAAGGAAGAACA GTGCCTGCCCAAGTGACTGACTTGCATGTGGCCAACCAAGGAATGACCAGTAGTCTGTTTACTAACTGG ACCCAGGCACAAGGAGACGTAGAATTTTACCAAGTCTTACTGATCCATGAAAATGTGGTCATTAAAAAT GAAAGCATCTCCAGTGAGACCAGCAGATACAGCTTCCACTCTCTCAAGTCCGGCAGCCTGTACTCCGTG GTGGTAACAACAGTGAGTGGAGGGATCTCTTCCCGACAAGTGGTTGTGGAGGGAAGAACAGTCCCTTCC AGTGTGAGTGGAGTAACGGTGAACAATTCCGGTCGTAATGACTACCTCAGCGTTTCCTGGCTGCTGGCG CCCGGAGATGTGGATAACTATGAGGTAACATTGTCTCATGACGGCAAGGTGGTTCAGTCCCTTGTCATT GCCAAGTCTGTCAGAGAATGTTCCTTCAGCTCCCTCACCCCAGGCCGCCTCTACACCGTGACCATAACT ACAAGGAGTGGCAAGTATGAAAATCACTCCTTCAGCCAAGAGCGGACAGTGCCTGACAAAGTCCAGGGA GTCAGTGTTAGCAACTCAGCCAGGAGTGACTATTTAAGGGTATCCTGGGTGCATGCCACTGGAGACTTT GATCACTATGAAGTCACCATTAAAAACAAAAACAACTTCATTCAAACTAAAAGCATTCCCAAGTCAGAA AACGAATGTGTATTTGTTCAGCTAGTCCCTGGACGGTTGTACAGTGTCACTGTTACTACAAAAAGTGGA CAATATGAAGCCAATGAACAAGGGAATGGGAGAACAATTCCAGAGCCTGTTAAGGATCTAACATTGCGC AACAGGAGCACTGAGGACTTGCATGTGACTTGGTCAGGAGCTAATGGGGATGTCGACCAATATGAGATC CAGCTGCTCTTCAATGACATGAAAGTATTTCCTCCTTTTCACCTTGTAAATACCGCAACCGAGTATCGA TTTACTTCCCTAACACCAGGCCGCCAATACAAAATTCTTGTCTTGACGATTAGCGGGGATGTACAGCAG TCAGCCTTCATTGAGGGCTTCACAGTTCCTAGTGCTGTCAAAAATATTCACATTTCTCCCAATGGAGCA ACAGATAGCCTGACGGTGAACTGGACTCCTGGTGGGGGAGACGTTGATTCCTACACGGTGTCGGCATTC AGGCACAGTCAAAAGGTTGACTCTCAGACTATTCCCAAGCACGTCTTTGAGCACACGTTCCACAGACTG GAGGCCGGGGAGCAGTACCAGATCATGATTGCCTCAGTCAGCGGGTCCCTGAAGAATCAGATAAATGTG GTTGGGCGGACAGTCCCAGCAGCTGTCACCGACCTGAGGATCACAGAGAACTCCACCAGGCACCTGTCC TTCCGCTGGACCGCCTCAGAGGGGGAGCTCAGCTGGTACAACATCTTTTTGTACAACCCAGATGGGAAT CTCCAGGAGAGAGCTCAAGTTGACCCACTAGTCCAGAGCTTCTCTTTCCAGAACTTGCTACAAGGCAGA ATGTACAAGATGGTGATTGTAACTCACAGTGGGGAGCTGTCTAATGAGTCTTTCATATTTGGTAGAACA GTCCCAGCCTCTGTGAGTCATCTCAGGGGGTCCAATCGGAACACGACAGACAGCCTTTGGTTCAACTGG AGTCCAGCCTCTGGGGACTTTGACTTTTATGAGCTGATTCTCTATAATCCCAATGGCACAAAGAAGGAA AACTGGAAAGACAAGGACCTGACGGAGTGGCGGTTTCAAGGCCTTGTTCCTGGAAGGAAGTACGTGCTG TGGGTGGTAACTCACAGTGGAGATCTCAGCAATAAAGTCACAGCGGAGAGCAGAACAGCTCCAAGTCCT CCCAGTCTTATGTCATTTGCTGACATTGCAAACACATCCTTGGCCATCACGTGGAAAGGGCCCCCAGAC TGGACAGACTACAACGACTTTGAGCTGCAGTGGTTGCCCAGAGATGCACTTACTGTCTTCAACCCCTAC AACAACAGAAAATCAGAAGGACGCATTGTGTATGGTCTTCGTCCAGGGAGATCCTATCAATTCAACGTC AAGACTGTCAGTGGTGATTCCTGGAAAACTTACAGCAAACCAATTTTTGGATCTGTGAGGACAAAGCCT GACAAGATACAAAACCTGCATTGCCGGCCTCAGAACTCCACGGCCATTGCCTGTTCTTGGATCCCTCCT GATTCTGACTTTGATGGTTATAGTATTGAATGCCGGAAAATGGACACCCAAGAAGTTGAGTTTTCCAGA AAGCTGGAGAAAGAAAAATCTCTGCTCAACATCATGATGCTAGTGCCCCATAAGAGGTACCTGGTGTCC ATCAAAGTGCAGTCGGCCGGCATGACCAGCGAGGTGGTTGAAGACAGCACTATCACAATGATAGACCGC CCCCCTCCTCCACCCCCACACATTCGTGTGAATGAAAAGGATGTGCTAATTAGCAAGTCTTCCATCAAC TTTACTGTCAACTGCAGCTGGTTCAGCGACACCAATGGAGCTGTGAAATACTTCACAGTGGTGGTGAGA GAGGCTGATGGCAGTGATGAGCTGAAGCCAGAACAGCAGCACCCTCTCCCTTCCTACCTGGAGTACAGG CACAATGCCTCCATTCGGGTGTATCAGACTAATTATTTTGCCAGCAAATGTGCCGAAAATCCTAACAGC AACTCCAAGAGTTTTAACATTAAGCTTGGAGCAGAGATGGAGAGCCTAGGTGGAAAATGCGATCCCACT CAGCAAAAATTCTGTGATGGACCACTGAAGCCACACACTGCCTACAGAATCAGCATTCGAGCTTTTACA CAGCTCTTTGATGAGGACCTGAAGGAATTCACAAAGCCACTCTATTCAGACACATTTTTTTCTTTACCC ATCACTACTGAATCAGAGCCCTTGTTTGGAGCTATTGAAGGTGTGAGTGCTGGTCTGTTTTTAATTGGC ATGCTAGTGGCTGTTGTTGCCTTATTGATCTGCAGACAGAAAGTGAGCCATGGTCGAGAAAGACCCTCT GCCCGTCTGAGCATTCGTAGGGATCGACCATTATCTGTCCACTTAAACCTGGGCCAGAAAGGTAACCGG AAAACTTCTTGTCCAATAAAAATAAATCAGTTTGAAGGGCATTTCATGAAGCTACAGGCTGACTCCAAC TACCTTCTATCCAAGGAATACGAGGAGTTAAAAGACGTGGGCCGAAACCAGTCATGTGACATTGCACTC TTGCCGGAGAATAGAGGGAAAAATCGATACAACAATATATTGCCCTATGATGCCACGCGAGTGAAGCTC TCCAATGTAGATGATGATCCTTGCTCTGACTACATCAATGCCAGCTACATCCCTGGCAACAACTTCAGA AGAGAATACATTGTCACTCAGGGACCGCTTCCTGGCACCAAGGATGACTTCTGGAAAATGGTGTGGGAA CAAAACGTTCACAACATCGTCATGGTGACCCAGTGTGTTGAGAAGGGCCGAGTAAAGTGTGACCATTAC TGGCCAGCGGACCAGGATTCCCTCTACTATGGGGACCTCATCCTGCAGATGCTCTCAGAGTCCGTCCTG CCTGAGTGGACCATCCGGGAGTTTAAGATATGCGGTGAGGAACAGCTTGATGCACACAGACTCATCCGC CACTTTCACTATACGGTGTGGCCAGACCATGGAGTCCCAGAAACCACCCAGTCTCTGATCCAGTTTGTG AGAACTGTCAGGGACTACATCAACAGAAGCCCGGGTGCTGGGCCCACTGTGGTGCACTGCAGTGCTGGT GTGGGTAGGACTGGAACCTTTATTGCATTGGACCGAATCCTCCAGCAGTTAGACTCCAAAGACTCTGTG GACATTTATGGAGCAGTGCACGACCTAAGACTTCACAGGGTTCACATGGTCCAGACTGAGTGTCAGTAT GTCTACCTACATCAGTGTGTAAGAGATGTCCTCAGAGCAAGAAAGCTACGGAGTGAACAAGAAAACCCC TTGTTTCCAATCTATGAAAATGTGAATCCAGAGTATCACAGAGATCCAGTCTATTCAAGGCATTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001206972
Insert Size	5724 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_001206972.1
RefSeq Size	10393 bp
RefSeq ORF	5724 bp
Locus ID	5787
UniProt ID	P23467
Protein Families	Druggable Genome, Phosphatase
Protein Pathways	Adherens junction
MW	214.5 kDa
Gene Summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] Transcript Variant: This variant (4) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (d) is shorter and has a distinct N-terminus compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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