FMO1 (NM_001282693) Human Untagged Clone
CAT#: SC336641
FMO1 (untagged) - Human flavin containing monooxygenase 1 (FMO1), transcript variant 3
CNY 5,130.00
货期*
4周
规格
Product images
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经常一起买 (4)
Specifications
Product Data | |
Type | Human Untagged Clone |
Tag | Tag Free |
Vector | pCMV6-Entry |
Sequence Data |
>SC336641 representing NM_001282693.
Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGCCAAGCGAGTTGCCATTGTGGGAGCTGGGGTCAGCGGCCTGGCCTCCATCAAGTGCTGTCTGGAA GAAGGACTGGAGCCCACCTGCTTTGAGAGGAGCGATGACCTTGGGGGGCTGTGGAGATTCACCGAACAT GTTGAAGAAGGCAGAGCCAGTCTCTACAAGTCTGTGGTTTCCAACAGCTGCAAGGAGATGTCTTGTTAC TCAGACTTTCCATTCCCAGAAGATTATCCAAACTATGTGCCAAATTCTCAATTCCTGGAATATCTCAAA ATGTATGCAAACCACTTTGACCTTCTGAAACACATTCAATTCAAGACCAAAGTCTGCAGTGTAACAAAA TGCTCAGATTCTGCTGTCTCTGGCCAATGGGAGGTGGTCACTATGCATGAAGAGAAGCAAGAGTCAGCC ATCTTTGATGCTGTCATGGTCTGCACTGGCTTTCTTACTAATCCTTATTTGCCACTGGATTCCTTTCCA GGTATTAATGCCTTTAAAGGCCAGTACTTTCATAGCCGGCAATATAAGCATCCAGATATATTTAAGGAC AAGAGAGTCCTTGTGATTGGAATGGGAAATTCTGGCACAGACATTGCTGTGGAGGCCAGCCACCTGGCG GAAAAGGTGTTCCTCAGCACCACCGGAGGGGGATGGGTGATCAGCCGAATCTTTGACTCGGGCTACCCA TGGGACATGGTGTTCATGACACGCTTTCAGAACATGTTGAGAAATTCCCTCCCAACCCCAATTGTGACT TGGTTGATGGAGCGAAAGATAAACAACTGGCTCAATCATGCAAATTACGGCTTAATACCAGAAGACAGG ACTCAGCTGAAAGAGTTTGTGCTAAATGATGAGCTCCCAGGACGCATCATCACTGGGAAAGTGTTCATC AGGCCAAGCATAAAAGAGGTAAAGGAAAACTCTGTCATATTTAACAATACTTCAAAGGAAGAGCCTATT GACATCATTGTCTTTGCCACTGGATACACATTTGCTTTCCCCTTCCTTGATGAGTCTGTAGTGAAAGTT GAAGATGGCCAGGCCTCACTGTACAAGTATATCTTCCCTGCACATCTGCAAAAGCCAACCCTGGCCATT ATTGGCCTCATCAAACCCTTGGGCTCCATGATACCTACAGGAGAAACACAAGCTCGGTGGGCTGTTCGA GTCCTGAAAGGTGTAAATAAGTTACCACCACCAAGTGTCATGATAGAGGAAATTAATGCAAGGAAAGAA AACAAGCCCAGTTGGTTTGGCTTGTGCTACTGCAAGGCTTTACAATCAGATTATATCACATACATAGAT GAACTCCTGACCTATATCAATGCAAAACCCAACCTGTTCTCTATGCTCCTAACGGATCCACATCTGGCT CTGACCGTCTTCTTTGGCCCATGCTCACCATACCAGTTCCGCTTGACTGGCCCAGGAAAATGGGAAGGA GCCAGAAATGCCATCATGACCCAGTGGGACCGAACATTCAAGGTCATCAAAGCTCGAGTTGTACAAGAG TCTCCATCTCCCTTTGAAAGTTTTCTTAAAGTCTTTAGCTTTCTGGCTTTGCTTGTGGCTATTTTTCTG ATTTTCCTATAA |
Restriction Sites | SgfI-MluI |
ACCN | NM_001282693 |
Insert Size | 1599 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_001282693.1 |
RefSeq Size | 2192 bp |
RefSeq ORF | 1599 bp |
Locus ID | 2326 |
UniProt ID | Q01740 |
Protein Families | Druggable Genome |
Protein Pathways | Drug metabolism - cytochrome P450 |
MW | 60.3 kDa |
Gene Summary | Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b). |
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