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Ing4 (NM_133345) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR203150L3V
- LentiORF®
-
Lenti ORF particles, Ing4 (Myc-DDK-tagged) - Mouse inhibitor of growth family, member 4 (Ing4), 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | Ing4 (NM_133345) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | D6Wsu147e; D6Xrf92; p29ING4 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_133345 |
| ORF Size | 747 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR203150).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_133345.1 |
| RefSeq Size | 1617 bp |
| RefSeq ORF | 747 bp |
| Locus ID | 28019 |
| Gene Summary | Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (By similarity). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (PubMed:11888890).[UniProtKB/Swiss-Prot Function] |
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