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Neil1 (BC043297) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR203232L3V
- LentiORF®
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Lenti ORF particles, Neil1 (Myc-DDK-tagged) - Mouse nei endonuclease VIII-like 1 (E. coli) (cDNA clone MGC:49102 IMAGE:5320651), 200ul, >10^7 TU/mL
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CNY 9,975.00
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Specifications
| Product Data | |
| Product Name | Neil1 (BC043297) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2810450N13Rik; Nei1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | BC043297 |
| ORF Size | 759 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR203232).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC043297, AAH43297 |
| RefSeq Size | 1857 bp |
| RefSeq ORF | 761 bp |
| Locus ID | 72774 |
| Gene Summary | Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.[UniProtKB/Swiss-Prot Function] |
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