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Pef1 (NM_026441) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR203692L4V
- LentiORF®
-
Lenti ORF particles, Pef1 (GFP-tagged) - Mouse penta-EF hand domain containing 1 (Pef1), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Pef1 (NM_026441) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2600002E23Rik; Peflin |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_026441 |
| ORF Size | 828 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR203692).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_026441.2, NP_080717.2 |
| RefSeq Size | 1551 bp |
| RefSeq ORF | 828 bp |
| Locus ID | 67898 |
| Gene Summary | Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats. In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification. Its role in the heterodimer formed with PDCD6 is however unclear: some evidence shows that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium. Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6 (By similarity). Also acts as a negative regulator of ER-Golgi transport; possibly by inhibiting interaction between PDCD6 and SEC31 (By similarity).[UniProtKB/Swiss-Prot Function] |
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