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Spop (NM_025287) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR205802L3V
- LentiORF®
-
Lenti ORF particles, Spop (Myc-DDK-tagged) - Mouse speckle-type POZ protein (Spop), 200ul, >10^7 TU/mL
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CNY 7,410.00
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| Product Data | |
| Product Name | Spop (NM_025287) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AI315626; Pcif1; TEF2 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_025287 |
| ORF Size | 1122 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR205802).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_025287.2, NP_079563.2 |
| RefSeq Size | 2882 bp |
| RefSeq ORF | 1125 bp |
| Locus ID | 20747 |
| Gene Summary | Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL (By similarity). In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation.[UniProtKB/Swiss-Prot Function] |
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