Cyp27a1 (BC002183) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR206963L3V

  • LentiORF®

Lenti ORF particles, Cyp27a1 (Myc-DDK-tagged) - Mouse cytochrome P450, family 27, subfamily a, polypeptide 1 (cDNA clone MGC:7368 IMAGE:3487429), 200ul, >10^7 TU/mL

ORF Plasmid: DDK tGFP



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CNY 9,975.00


货期*
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规格
    • 200 ul

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Specifications

Product Data
Product Name Cyp27a1 (BC002183) Mouse Tagged ORF Clone Lentiviral Particle
Synonyms 1300013A03Rik; Cyp27
Vector pLenti-C-Myc-DDK-P2A-Puro
ACCN BC002183
ORF Size 1311 bp
Sequence Data
The ORF insert of this clone is exactly the same as(MR206963).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq BC002183, AAH02183
RefSeq Size 1579 bp
RefSeq ORF 1313 bp
Locus ID 104086
Gene Summary Cytochrome P450 monooxygenase that catalyzes regio- and stereospecific hydroxylation of cholesterol and its derivatives. Hydroxylates (with R stereochemistry) the terminal methyl group of cholesterol side-chain in a three step reaction to yield at first a C26 alcohol, then a C26 aldehyde and finally a C26 acid. Regulates cholesterol homeostasis by catalyzing the conversion of excess cholesterol to bile acids via both the "neutral" (classic) and the "acid" (alternative) pathways. May also regulate cholesterol homeostasis via generation of active oxysterols, which act as ligands for NR1H2 and NR1H3 nuclear receptors, modulating the transcription of genes involved in lipid metabolism (By similarity). Plays a role in cholestanol metabolism in the cerebellum (PubMed:28190002). Similarly to cholesterol, hydroxylates cholestanol and may facilitate sterol diffusion through the blood-brain barrier to the systemic circulation for further degradation. Also hydroxylates retinal 7-ketocholesterol, a noxious oxysterol with pro-inflammatory and pro-apoptotic effects, and may play a role in its elimination from the retinal pigment epithelium. May play a redundant role in vitamin D biosynthesis. Catalyzes 25-hydroxylation of vitamin D3 that is required for its conversion to a functionally active form (By similarity).[UniProtKB/Swiss-Prot Function]
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