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Pak2 (NM_177326) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR208417L4V
- LentiORF®
-
Lenti ORF particles, Pak2 (GFP-tagged) - Mouse p21 protein (Cdc42/Rac)-activated kinase 2 (Pak2), 200ul, >10^7 TU/mL
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CNY 10,925.00
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Specifications
| Product Data | |
| Product Name | Pak2 (NM_177326) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 5330420P17Rik; A130002K10Rik; AI836325; D16Ertd269e; mKIAA4182; PAK-2 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_177326 |
| ORF Size | 1572 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR208417).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_177326.2, NP_796300.1 |
| RefSeq Size | 4135 bp |
| RefSeq ORF | 1575 bp |
| Locus ID | 224105 |
| Gene Summary | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (By similarity).[UniProtKB/Swiss-Prot Function] |
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