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Dyrk3 (NM_145508) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR209158L3V
- LentiORF®
-
Lenti ORF particles, Dyrk3 (Myc-DDK-tagged) - Mouse dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 (Dyrk3), 200ul, >10^7 TU/mL
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CNY 10,450.00
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Specifications
| Product Data | |
| Product Name | Dyrk3 (NM_145508) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | BC006704 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_145508 |
| ORF Size | 1758 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR209158).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_145508.2, NP_663483.1 |
| RefSeq Size | 2072 bp |
| RefSeq ORF | 1761 bp |
| Locus ID | 226419 |
| Gene Summary | Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (By similarity). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues (PubMed:12356771). Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1 (By similarity). Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3 (By similarity). Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis (By similarity). Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling (By similarity). When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling (By similarity). Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis (By similarity). Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603).[UniProtKB/Swiss-Prot Function] |
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