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Sh3bp1 (BC004598) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR209303L3V
- LentiORF®
-
Lenti ORF particles, Sh3bp1 (Myc-DDK-tagged) - Mouse SH3-domain binding protein 1 (cDNA clone MGC:6037 IMAGE:3584958), 200ul, >10^7 TU/mL
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CNY 9,975.00
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Specifications
| Product Data | |
| Product Name | Sh3bp1 (BC004598) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 3BP-1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | BC004598 |
| ORF Size | 1800 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR209303).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC004598, AAH04598 |
| RefSeq Size | 2224 bp |
| RefSeq ORF | 1802 bp |
| Locus ID | 20401 |
| Gene Summary | GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form (PubMed:7621827). By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration. Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment. It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (By similarity).[UniProtKB/Swiss-Prot Function] |
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