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Grhl3 (NM_001013756) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR209332L3V
- LentiORF®
-
Lenti ORF particles, Grhl3 (Myc-DDK-tagged) - Mouse grainyhead-like 3 (Drosophila) (Grhl3), 200ul, >10^7 TU/mL
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CNY 10,640.00
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Specifications
| Product Data | |
| Product Name | Grhl3 (NM_001013756) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AI561912; ct; Get1; Som; Tfcp2l4 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001013756 |
| ORF Size | 1812 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR209332).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001013756.1 |
| RefSeq Size | 2798 bp |
| RefSeq ORF | 1812 bp |
| Locus ID | 230824 |
| Gene Summary | Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes. Essential for epidermal differentiation and barrier formation at the end of embryogenesis with TGM3 as critical direct target (PubMed:21081122, PubMed:20654612, PubMed:25347468). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events such as eyelid fusion and epidermal wound repair (PubMed:21081122). Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury (PubMed:25347468). Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (PubMed:14608380, PubMed:20654612). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL1, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122).[UniProtKB/Swiss-Prot Function] |
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