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Tbc1d23 (NM_026254) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR210025L4V
- LentiORF®
-
Lenti ORF particles, Tbc1d23 (GFP-tagged) - Mouse TBC1 domain family, member 23 (Tbc1d23), 200ul, >10^7 TU/mL
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CNY 12,920.00
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Specifications
| Product Data | |
| Product Name | Tbc1d23 (NM_026254) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 4930451A13Rik; AU015720; AU043671; AU043778; D030022P07Rik; W51689 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_026254 |
| ORF Size | 2055 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR210025).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_026254.2, NP_080530.2 |
| RefSeq Size | 3664 bp |
| RefSeq ORF | 2055 bp |
| Locus ID | 67581 |
| Gene Summary | Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (By similarity). Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes which are essential for axonal and dendritic growth (PubMed:28823707). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (PubMed:22312129).[UniProtKB/Swiss-Prot Function] |
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